TopFIND 4.0

Q53G59: Kelch-like protein 12

General Information

Protein names
- Kelch-like protein 12
- CUL3-interacting protein 1 {ECO:0000303|Ref.1}
- DKIR homolog {ECO:0000303|PubMed:15383316}
- hDKIR {ECO:0000303|PubMed:15383316}
Gene names KLHL12
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q53G59

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MGGIMAPKDI MTNTHAKSIL NSMNSLRKSN TLCDVTLRVE QKDFPAHRIV LAACSDYFCA 
        70         80         90        100        110        120 
MFTSELSEKG KPYVDIQGLT ASTMEILLDF VYTETVHVTV ENVQELLPAA CLLQLKGVKQ 
       130        140        150        160        170        180 
ACCEFLESQL DPSNCLGIRD FAETHNCVDL MQAAEVFSQK HFPEVVQHEE FILLSQGEVE 
       190        200        210        220        230        240 
KLIKCDEIQV DSEEPVFEAV INWVKHAKKE REESLPNLLQ YVRMPLLTPR YITDVIDAEP 
       250        260        270        280        290        300 
FIRCSLQCRD LVDEAKKFHL RPELRSQMQG PRTRARLGAN EVLLVVGGFG SQQSPIDVVE 
       310        320        330        340        350        360 
KYDPKTQEWS FLPSITRKRR YVASVSLHDR IYVIGGYDGR SRLSSVECLD YTADEDGVWY 
       370        380        390        400        410        420 
SVAPMNVRRG LAGATTLGDM IYVSGGFDGS RRHTSMERYD PNIDQWSMLG DMQTAREGAG 
       430        440        450        460        470        480 
LVVASGVIYC LGGYDGLNIL NSVEKYDPHT GHWTNVTPMA TKRSGAGVAL LNDHIYVVGG 
       490        500        510        520        530        540 
FDGTAHLSSV EAYNIRTDSW TTVTSMTTPR CYVGATVLRG RLYAIAGYDG NSLLSSIECY 
       550        560    
DPIIDSWEVV TSMGTQRCDA GVCVLREK

Isoforms

- Isoform 2 of Kelch-like protein 12

Sequence View

        10         20         30         40         50         60 
MGGIMAPKDI MTNTHAKSIL NSMNSLRKSN TLCDVTLRVE QKDFPAHRIV LAACSDYFCA 
        70         80         90        100        110        120 
MFTSELSEKG KPYVDIQGLT ASTMEILLDF VYTETVHVTV ENVQELLPAA CLLQLKGVKQ 
       130        140        150        160        170        180 
ACCEFLESQL DPSNCLGIRD FAETHNCVDL MQAAEVFSQK HFPEVVQHEE FILLSQGEVE 
       190        200        210        220        230        240 
KLIKCDEIQV DSEEPVFEAV INWVKHAKKE REESLPNLLQ YVRMPLLTPR YITDVIDAEP 
       250        260        270        280        290        300 
FIRCSLQCRD LVDEAKKFHL RPELRSQMQG PRTRARLGAN EVLLVVGGFG SQQSPIDVVE 
       310        320        330        340        350        360 
KYDPKTQEWS FLPSITRKRR YVASVSLHDR IYVIGGYDGR SRLSSVECLD YTADEDGVWY 
       370        380        390        400        410        420 
SVAPMNVRRG LAGATTLGDM IYVSGGFDGS RRHTSMERYD PNIDQWSMLG DMQTAREGAG 
       430        440        450        460        470        480 
LVVASGVIYC LGGYDGLNIL NSVEKYDPHT GHWTNVTPMA TKRSGAGVAL LNDHIYVVGG 
       490        500        510        520        530        540 
FDGTAHLSSV EAYNIRTDSW TTVTSMTTPR CYVGATVLRG RLYAIAGYDG NSLLSSIECY 
       550        560    
DPIIDSWEVV TSMGTQRCDA GVCVLREK



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Physiological Relevance:


Evidence Codes:


Methodology:


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Biological System:


Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q53G59-1-unknown MGGIMA... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q53G59-1-unknown MGGIMA... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt108731

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...VLREK 568 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...VLREK 568 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt74709

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)