TopFIND 4.0

Q53GS9: U4/U6.U5 tri-snRNP-associated protein 2

General Information

Protein names
- U4/U6.U5 tri-snRNP-associated protein 2
- Inactive ubiquitin-specific peptidase 39 {ECO:0000303|PubMed:18728397}
- SAD1 homolog {ECO:0000303|PubMed:11350945}
- U4/U6.U5 tri-snRNP-associated 65 kDa protein {ECO:0000303|PubMed:11350945}
- 65K {ECO:0000303|PubMed:11350945}
Gene names USP39
Organism Homo sapiens
Protease Family
Protease ID C19.972
Chromosome location
UniProt ID Q53GS9

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MSGRSKRESR GSTRGKRESE SRGSSGRVKR ERDREREPEA ASSRGSPVRV KREFEPASAR 
        70         80         90        100        110        120 
EAPASVVPFV RVKREREVDE DSEPEREVRA KNGRVDSEDR RSRHCPYLDT INRSVLDFDF 
       130        140        150        160        170        180 
EKLCSISLSH INAYACLVCG KYFQGRGLKS HAYIHSVQFS HHVFLNLHTL KFYCLPDNYE 
       190        200        210        220        230        240 
IIDSSLEDIT YVLKPTFTKQ QIANLDKQAK LSRAYDGTTY LPGIVGLNNI KANDYANAVL 
       250        260        270        280        290        300 
QALSNVPPLR NYFLEEDNYK NIKRPPGDIM FLLVQRFGEL MRKLWNPRNF KAHVSPHEML 
       310        320        330        340        350        360 
QAVVLCSKKT FQITKQGDGV DFLSWFLNAL HSALGGTKKK KKTIVTDVFQ GSMRIFTKKL 
       370        380        390        400        410        420 
PHPDLPAEEK EQLLHNDEYQ ETMVESTFMY LTLDLPTAPL YKDEKEQLII PQVPLFNILA 
       430        440        450        460        470        480 
KFNGITEKEY KTYKENFLKR FQLTKLPPYL IFCIKRFTKN NFFVEKNPTI VNFPITNVDL 
       490        500        510        520        530        540 
REYLSEEVQA VHKNTTYDLI ANIVHDGKPS EGSYRIHVLH HGTGKWYELQ DLQVTDILPQ 
       550        560    
MITLSEAYIQ IWKRRDNDET NQQGA

Isoforms

- Isoform 2 of U4/U6.U5 tri-snRNP-associated protein 2 - Isoform 3 of U4/U6.U5 tri-snRNP-associated protein 2

Sequence View

        10         20         30         40         50         60 
MSGRSKRESR GSTRGKRESE SRGSSGRVKR ERDREREPEA ASSRGSPVRV KREFEPASAR 
        70         80         90        100        110        120 
EAPASVVPFV RVKREREVDE DSEPEREVRA KNGRVDSEDR RSRHCPYLDT INRSVLDFDF 
       130        140        150        160        170        180 
EKLCSISLSH INAYACLVCG KYFQGRGLKS HAYIHSVQFS HHVFLNLHTL KFYCLPDNYE 
       190        200        210        220        230        240 
IIDSSLEDIT YVLKPTFTKQ QIANLDKQAK LSRAYDGTTY LPGIVGLNNI KANDYANAVL 
       250        260        270        280        290        300 
QALSNVPPLR NYFLEEDNYK NIKRPPGDIM FLLVQRFGEL MRKLWNPRNF KAHVSPHEML 
       310        320        330        340        350        360 
QAVVLCSKKT FQITKQGDGV DFLSWFLNAL HSALGGTKKK KKTIVTDVFQ GSMRIFTKKL 
       370        380        390        400        410        420 
PHPDLPAEEK EQLLHNDEYQ ETMVESTFMY LTLDLPTAPL YKDEKEQLII PQVPLFNILA 
       430        440        450        460        470        480 
KFNGITEKEY KTYKENFLKR FQLTKLPPYL IFCIKRFTKN NFFVEKNPTI VNFPITNVDL 
       490        500        510        520        530        540 
REYLSEEVQA VHKNTTYDLI ANIVHDGKPS EGSYRIHVLH HGTGKWYELQ DLQVTDILPQ 
       550        560    
MITLSEAYIQ IWKRRDNDET NQQGA         10         20         30         40         50         60 
MSGRSKRESR GSTRGKRESE SRGSSGRVKR ERDREREPEA ASSRGSPVRV KREFEPASAR 
        70         80         90        100        110        120 
EAPASVVPFV RVKREREVDE DSEPEREVRA KNGRVDSEDR RSRHCPYLDT INRSVLDFDF 
       130        140        150        160        170        180 
EKLCSISLSH INAYACLVCG KYFQGRGLKS HAYIHSVQFS HHVFLNLHTL KFYCLPDNYE 
       190        200        210        220        230        240 
IIDSSLEDIT YVLKPTFTKQ QIANLDKQAK LSRAYDGTTY LPGIVGLNNI KANDYANAVL 
       250        260        270        280        290        300 
QALSNVPPLR NYFLEEDNYK NIKRPPGDIM FLLVQRFGEL MRKLWNPRNF KAHVSPHEML 
       310        320        330        340        350        360 
QAVVLCSKKT FQITKQGDGV DFLSWFLNAL HSALGGTKKK KKTIVTDVFQ GSMRIFTKKL 
       370        380        390        400        410        420 
PHPDLPAEEK EQLLHNDEYQ ETMVESTFMY LTLDLPTAPL YKDEKEQLII PQVPLFNILA 
       430        440        450        460        470        480 
KFNGITEKEY KTYKENFLKR FQLTKLPPYL IFCIKRFTKN NFFVEKNPTI VNFPITNVDL 
       490        500        510        520        530        540 
REYLSEEVQA VHKNTTYDLI ANIVHDGKPS EGSYRIHVLH HGTGKWYELQ DLQVTDILPQ 
       550        560    
MITLSEAYIQ IWKRRDNDET NQQGA



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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q53GS9-1-unknown MSGRSK... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q53GS9-1-unknown MSGRSK... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt90162

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...NQQGA 565 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...NQQGA 565 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt85779

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)