Q53GT1: Kelch-like protein 22 {ECO:0000305}

General Information

Protein names	- Kelch-like protein 22 {ECO:0000305}
Gene names	KLHL22
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q53GT1

4 N-termini

6 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAEEQEFTQL CKLPAQPSHP HCVNNTYRSA QHSQALLRGL LALRDSGILF DVVLVVEGRH
        70         80         90        100        110        120
IEAHRILLAA SCDYFRGMFA GGLKEMEQEE VLIHGVSYNA MCQILHFIYT SELELSLSNV
       130        140        150        160        170        180
QETLVAACQL QIPEIIHFCC DFLMSWVDEE NILDVYRLAE LFDLSRLTEQ LDTYILKNFV
       190        200        210        220        230        240
AFSRTDKYRQ LPLEKVYSLL SSNRLEVSCE TEVYEGALLY HYSLEQVQAD QISLHEPPKL
       250        260        270        280        290        300
LETVRFPLME AEVLQRLHDK LDPSPLRDTV ASALMYHRNE SLQPSLQSPQ TELRSDFQCV
       310        320        330        340        350        360
VGFGGIHSTP STVLSDQAKY LNPLLGEWKH FTASLAPRMS NQGIAVLNNF VYLIGGDNNV
       370        380        390        400        410        420
QGFRAESRCW RYDPRHNRWF QIQSLQQEHA DLSVCVVGRY IYAVAGRDYH NDLNAVERYD
       430        440        450        460        470        480
PATNSWAYVA PLKREVYAHA GATLEGKMYI TCGRRGEDYL KETHCYDPGS NTWHTLADGP
       490        500        510        520        530        540
VRRAWHGMAT LLNKLYVIGG SNNDAGYRRD VHQVACYSCT SGQWSSVCPL PAGHGEPGIA
       550        560        570        580        590        600
VLDNRIYVLG GRSHNRGSRT GYVHIYDVEK DCWEEGPQLD NSISGLAACV LTLPRSLLLE
       610        620        630
PPRGTPDRSQ ADPDFASEVM SVSDWEEFDN SSED

Isoforms

- Isoform 2 of Kelch-like protein 22

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 6 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name
Q53GT1-2-unknown	MAEEQE...	1		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
Q53GT1-2-unknown	MAEEQE...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q53GT1-2-Acetylation	AEEQEF...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q53GT1-2-Acetylation	AEEQEF...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q53GT1-2-Acetylation	AEEQEF...	2	acetylation-	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
Q53GT1-78-unknown	MFAGGL...	78		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000400095
Q53GT1-144-unknown	MSWVDE...	144		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000405521

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SCDYFR	75	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000402746
...VYEGAL	217	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000397882
...QISLHE	235	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000398616
...DKLDPS	263	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000403999
...QCVVGF	302	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000400095
...NSSED	634	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)