TopFIND 4.0

Q53HV7: Single-strand selective monofunctional uracil DNA glycosylase

General Information

Protein names
- Single-strand selective monofunctional uracil DNA glycosylase
- 3.2.2.-
Gene names SMUG1
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q53HV7

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MPQAFLLGSI HEPAGALMEP QPCPGSLAES FLEEELRLNA ELSQLQFSEP VGIIYNPVEY 
        70         80         90        100        110        120 
AWEPHRNYVT RYCQGPKEVL FLGMNPGPFG MAQTGVPFGE VSMVRDWLGI VGPVLTPPQE 
       130        140        150        160        170        180 
HPKRPVLGLE CPQSEVSGAR FWGFFRNLCG QPEVFFHHCF VHNLCPLLFL APSGRNLTPA 
       190        200        210        220        230        240 
ELPAKQREQL LGICDAALCR QVQLLGVRLV VGVGRLAEQR ARRALAGLMP EVQVEGLLHP 
       250        260        270    
SPRNPQANKG WEAVAKERLN ELGLLPLLLK 

Isoforms

- Isoform 2 of Single-strand selective monofunctional uracil DNA glycosylase

Sequence View

        10         20         30         40         50         60 
MPQAFLLGSI HEPAGALMEP QPCPGSLAES FLEEELRLNA ELSQLQFSEP VGIIYNPVEY 
        70         80         90        100        110        120 
AWEPHRNYVT RYCQGPKEVL FLGMNPGPFG MAQTGVPFGE VSMVRDWLGI VGPVLTPPQE 
       130        140        150        160        170        180 
HPKRPVLGLE CPQSEVSGAR FWGFFRNLCG QPEVFFHHCF VHNLCPLLFL APSGRNLTPA 
       190        200        210        220        230        240 
ELPAKQREQL LGICDAALCR QVQLLGVRLV VGVGRLAEQR ARRALAGLMP EVQVEGLLHP 
       250        260        270    
SPRNPQANKG WEAVAKERLN ELGLLPLLLK 



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Evidence Codes:


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Protease Assignment Confidence:


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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q53HV7-1-unknown MPQAFL... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q53HV7-1-unknown MPQAFL... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt90111

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...PLLLK 270 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)