Q53RT3: Retroviral-like aspartic protease 1
| Protein names | - Retroviral-like aspartic protease 1 - 3.4.23.- - Skin-specific retroviral-like aspartic protease - SASPase - Skin aspartic protease - TPA-inducible aspartic proteinase-like protein - TAPS |
|---|---|
| Gene names | ASPRV1 |
| Organism | Homo sapiens |
| Protease Family | A33.001 |
| Protease ID | A33.001 |
| Chromosome location | |
| UniProt ID | Q53RT3 |
3
N-termini
3
C-termini
3
Cleavages
3
Substrates
Sequence
10 20 30 40 50 60
MGSPGASLGI KKALQSEQAT ALPASAPAVS QPTAPAPSCL PKAGQVIPTL LREAPFSSVI
70 80 90 100 110 120
APTLLCGFLF LAWVAAEVPE ESSRMAGSGA RSEEGRRQHA FVPEPFDGAN VVPNLWLHSF
130 140 150 160 170 180
EVINDLNHWD HITKLRFLKE SLRGEALGVY NRLSPQDQGD YGTVKEALLK AFGVPGAAPS
190 200 210 220 230 240
HLPKEIVFAN SMGKGYYLKG KIGKVPVRFL VDSGAQVSVV HPNLWEEVTD GDLDTLQPFE
250 260 270 280 290 300
NVVKVANGAE MKILGVWDTA VSLGKLKLKA QFLVANASAE EAIIGTDVLQ DHNAILDFEH
310 320 330 340
RTCTLKGKKF RLLPVGGSLE DEFDLELIEE DPSSEEGRQE LSH
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
3 N-termini - 3 C-termini - 3 Cleavages - 3 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| Q53RT3-168-unknown | LLKAFG... | 168 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC262 | |||
| Q53RT3-191-unknown | SMGKGY... | 191 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| Q53RT3-191-unknown | SMGKGY... | 191 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC263 | |||
| Q53RT3-327-unknown | LIEEDP... | 327 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC264 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...TVKEAL | 167 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC262 | |||
| ...IVFANS | 190 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC263 | |||
| ...EFDLEL | 326 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| ...EFDLEL | 326 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC264 |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| APRV1_HUMAN | 167 | KEAL.|.LLKA | inferred from experiment | unknown | MEROPS | Schmidt R | Bernard D et al.:Identification and characteriza... (A33.001) | 16098038, |
| APRV1_HUMAN | 190 | FANS.|.SMGK | inferred from experiment | unknown | MEROPS | Schmidt R | Bernard D et al.:Identification and characteriza... (A33.001) | 16098038, |
| APRV1_HUMAN | 326 | DLEL.|.LIEE | inferred from experiment | unknown | MEROPS | Schmidt R | Bernard D et al.:Identification and characteriza... (A33.001) | 16098038, |
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| APRV1_HUMAN | 167 | KEAL.|.LLKA | inferred from experiment | unknown | MEROPS | Schmidt R | Bernard D et al.:Identification and characteriza... (A33.001) | 16098038, |
| APRV1_HUMAN | 190 | FANS.|.SMGK | inferred from experiment | unknown | MEROPS | Schmidt R | Bernard D et al.:Identification and characteriza... (A33.001) | 16098038, |
| APRV1_HUMAN | 326 | DLEL.|.LIEE | inferred from experiment | unknown | MEROPS | Schmidt R | Bernard D et al.:Identification and characteriza... (A33.001) | 16098038, |