Q5HYA8: Meckelin

General Information

Protein names	- Meckelin - Meckel syndrome type 3 protein - Transmembrane protein 67
Gene names	TMEM67
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q5HYA8

3 N-termini

5 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MATRGGAGVA MAVWSLLSAR AVTAFLLLFL PRFLQAQTFS FPFQQPEKCD NNQYFDISAL
        70         80         90        100        110        120
SCVPCGANQR QDARGTSCVC LPGFQMISNN GGPAIICKKC PENMKGVTED GWNCISCPSD
       130        140        150        160        170        180
LTAEGKCHCP IGHILVERDI NGTLLSQATC ELCDGNENSF MVVNALGDRC VRCEPTFVNT
       190        200        210        220        230        240
SRSCACSEPN ILTGGLCFSS TGNFPLRRIS AARYGEVGMS LTSEWFAKYL QSSAAACWVY
       250        260        270        280        290        300
ANLTSCQALG NMCVMNMNSY DFATFDACGL FQFIFENTAG LSTVHSISFW RQNLPWLFYG
       310        320        330        340        350        360
DQLGLAPQVL SSTSLPTNFS FKGENQNTKL KFVAASYDIR GNFLKWQTLE GGVLQLCPDT
       370        380        390        400        410        420
ETRLNAAYSF GTTYQQNCEI PISKILIDFP TPIFYDVYLE YTDENQHQYI LAVPVLNLNL
       430        440        450        460        470        480
QHNKIFVNQD SNSGKWLLTR RIFLVDAVSG RENDLGTQPR VIRVATQISL SVHLVPNTIN
       490        500        510        520        530        540
GNIYPPLITI AYSDIDIKDA NSQSVKVSFS VTYEMDHGEA HVQTDIALGV LGGLAVLASL
       550        560        570        580        590        600
LKTAGWKRRI GSPMIDLQTV VKFLVYYAGD LANVFFIITV GTGLYWLIFF KAQKSVSVLL
       610        620        630        640        650        660
PMPIQEERFV TYVGCAFALK ALQFLHKLIS QITIDVFFID WERPKGKVLK AVEGEGGVRS
       670        680        690        700        710        720
ATVPVSIWRT YFVANEWNEI QTVRKINSLF QVLTVLFFLE VVGFKNLALM DSSSSLSRNP
       730        740        750        760        770        780
PSYIAPYSCI LRYAVSAALW LAIGIIQVVF FAVFYERFIE DKIRQFVDLC SMSNISVFLL
       790        800        810        820        830        840
SHKCFGYYIH GRSVHGHADT NMEEMNMNLK REAENLCSQR GLVPNTDGQT FEIAISNQMR
       850        860        870        880        890        900
QHYDRIHETL IRKNGPARLL SSSASTFEQS IKAYHMMNKF LGSFIDHVHK EMDYFIKDKL
       910        920        930        940        950        960
LLERILGMEF MEPMEKSIFY NDEGYSFSSV LYYGNEATLL IFDLLFFCVV DLACQNFILA
       970        980        990
SFLTYLQQEI FRYIRNTVGQ KNLASKTLVD QRFLI

Isoforms

- Isoform 2 of Meckelin

Sequence View

        10         20         30         40         50         60
MATRGGAGVA MAVWSLLSAR AVTAFLLLFL PRFLQAQTFS FPFQQPEKCD NNQYFDISAL
        70         80         90        100        110        120
SCVPCGANQR QDARGTSCVC LPGFQMISNN GGPAIICKKC PENMKGVTED GWNCISCPSD
       130        140        150        160        170        180
LTAEGKCHCP IGHILVERDI NGTLLSQATC ELCDGNENSF MVVNALGDRC VRCEPTFVNT
       190        200        210        220        230        240
SRSCACSEPN ILTGGLCFSS TGNFPLRRIS AARYGEVGMS LTSEWFAKYL QSSAAACWVY
       250        260        270        280        290        300
ANLTSCQALG NMCVMNMNSY DFATFDACGL FQFIFENTAG LSTVHSISFW RQNLPWLFYG
       310        320        330        340        350        360
DQLGLAPQVL SSTSLPTNFS FKGENQNTKL KFVAASYDIR GNFLKWQTLE GGVLQLCPDT
       370        380        390        400        410        420
ETRLNAAYSF GTTYQQNCEI PISKILIDFP TPIFYDVYLE YTDENQHQYI LAVPVLNLNL
       430        440        450        460        470        480
QHNKIFVNQD SNSGKWLLTR RIFLVDAVSG RENDLGTQPR VIRVATQISL SVHLVPNTIN
       490        500        510        520        530        540
GNIYPPLITI AYSDIDIKDA NSQSVKVSFS VTYEMDHGEA HVQTDIALGV LGGLAVLASL
       550        560        570        580        590        600
LKTAGWKRRI GSPMIDLQTV VKFLVYYAGD LANVFFIITV GTGLYWLIFF KAQKSVSVLL
       610        620        630        640        650        660
PMPIQEERFV TYVGCAFALK ALQFLHKLIS QITIDVFFID WERPKGKVLK AVEGEGGVRS
       670        680        690        700        710        720
ATVPVSIWRT YFVANEWNEI QTVRKINSLF QVLTVLFFLE VVGFKNLALM DSSSSLSRNP
       730        740        750        760        770        780
PSYIAPYSCI LRYAVSAALW LAIGIIQVVF FAVFYERFIE DKIRQFVDLC SMSNISVFLL
       790        800        810        820        830        840
SHKCFGYYIH GRSVHGHADT NMEEMNMNLK REAENLCSQR GLVPNTDGQT FEIAISNQMR
       850        860        870        880        890        900
QHYDRIHETL IRKNGPARLL SSSASTFEQS IKAYHMMNKF LGSFIDHVHK EMDYFIKDKL
       910        920        930        940        950        960
LLERILGMEF MEPMEKSIFY NDEGYSFSSV LYYGNEATLL IFDLLFFCVV DLACQNFILA
       970        980        990
SFLTYLQQEI FRYIRNTVGQ KNLASKTLVD QRFLI

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q5HYA8-1-unknown	MATRGG...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q5HYA8-104-unknown	MKGVTE...	104	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000388671
Q5HYA8-161-unknown	MVVNAL...	161	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000430289
Q5HYA8-161-unknown	MVVNAL...	161	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt131623

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GGLCFS	198	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000430289
...GGLCFS	198	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112162
...LSVHLV	474	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000403035
...LSVHLV	474	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112164
...DIKDAN	500	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000388671
...DIKDAN	500	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112160
...WLIFFK	590	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000428785
...WLIFFK	590	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112166
...QRFLI	995	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...QRFLI	995	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76858

TopFIND

Q5HYA8: Meckelin

General Information

3

N-termini

5

C-termini

0

Cleavages

0

Substrates

Sequence

Isoforms

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Protein Neighborhood

Domains & Features

3 N-termini - 5 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates