Q5T2W1: Na(+)/H(+) exchange regulatory cofactor NHE-RF3

General Information

Protein names	- Na(+)/H(+) exchange regulatory cofactor NHE-RF3 - NHERF-3 - CFTR-associated protein of 70 kDa - Na(+)/H(+) exchanger regulatory factor 3 - Na/Pi cotransporter C-terminal-associated protein 1 - NaPi-Cap1 - PDZ domain-containing protein 1 - Sodium-hydrogen exchanger regulatory factor 3
Gene names	PDZK1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q5T2W1

1 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MTSTFNPREC KLSKQEGQNY GFFLRIEKDT EGHLVRVVEK CSPAEKAGLQ DGDRVLRING
        70         80         90        100        110        120
VFVDKEEHMQ VVDLVRKSGN SVTLLVLDGD SYEKAVKTRV DLKELGQSQK EQGLSDNILS
       130        140        150        160        170        180
PVMNGGVQTW TQPRLCYLVK EGGSYGFSLK TVQGKKGVYM TDITPQGVAM RAGVLADDHL
       190        200        210        220        230        240
IEVNGENVED ASHEEVVEKV KKSGSRVMFL LVDKETDKRH VEQKIQFKRE TASLKLLPHQ
       250        260        270        280        290        300
PRIVEMKKGS NGYGFYLRAG SEQKGQIIKD IDSGSPAEEA GLKNNDLVVA VNGESVETLD
       310        320        330        340        350        360
HDSVVEMIRK GGDQTSLLVV DKETDNMYRL AHFSPFLYYQ SQELPNGSVK EAPAPTPTSL
       370        380        390        400        410        420
EVSSPPDTTE EVDHKPKLCR LAKGENGYGF HLNAIRGLPG SFIKEVQKGG PADLAGLEDE
       430        440        450        460        470        480
DVIIEVNGVN VLDEPYEKVV DRIQSSGKNV TLLVCGKKAY DYFQAKKIPI VSSLADPLDT
       490        500        510
PPDSKEGIVV ESNHDSHMAK ERAHSTASHS SSNSEDTEM

Isoforms

- Isoform 2 of Na(+)/H(+) exchange regulatory cofactor NHE-RF3

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

1 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q5T2W1-1-unknown	MTSTFN...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q5T2W1-1-unknown	MTSTFN...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt82832

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GSEQKG	264	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000409291
...GSEQKG	264	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000462094
...EDTEM	519	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...EDTEM	519	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78450

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)