Q5T4D3: Protein O-mannosyl-transferase TMTC4 {ECO:0000305}

General Information

Protein names	- Protein O-mannosyl-transferase TMTC4 {ECO:0000305} - 2.4.1.109 {ECO:0000269\|PubMed:28973932} - Transmembrane and TPR repeat-containing protein 4 {ECO:0000312\|HGNC:HGNC:25904}
Gene names	TMTC4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q5T4D3

1 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAVLDTDLDH ILPSSVLPPF WAKLVVGSVA IVCFARSYDG DFVFDDSEAI VNNKDLQAET
        70         80         90        100        110        120
PLGDLWHHDF WGSRLSSNTS HKSYRPLTVL TFRINYYLSG GFHPVGFHVV NILLHSGISV
       130        140        150        160        170        180
LMVDVFSVLF GGLQYTSKGR RLHLAPRASL LAALLFAVHP VHTECVAGVV GRADLLCALF
       190        200        210        220        230        240
FLLSFLGYCK AFRESNKEGA HSSTFWVLLS IFLGAVAMLC KEQGITVLGL NAVFDILVIG
       250        260        270        280        290        300
KFNVLEIVQK VLHKDKSLEN LGMLRNGGLL FRMTLLTSGG AGMLYVRWRI MGTGPPAFTE
       310        320        330        340        350        360
VDNPASFADS MLVRAVNYNY YYSLNAWLLL CPWWLCFDWS MGCIPLIKSI SDWRVIALAA
       370        380        390        400        410        420
LWFCLIGLIC QALCSEDGHK RRILTLGLGF LVIPFLPASN LFFRVGFVVA ERVLYLPSVG
       430        440        450        460        470        480
YCVLLTFGFG ALSKHTKKKK LIAAVVLGIL FINTLRCVLR SGEWRSEEQL FRSALSVCPL
       490        500        510        520        530        540
NAKVHYNIGK NLADKGNQTA AIRYYREAVR LNPKYVHAMN NLGNILKERN ELQEAEELLS
       550        560        570        580        590        600
LAVQIQPDFA AAWMNLGIVQ NSLKRFEAAE QSYRTAIKHR RKYPDCYYNL GRLYADLNRH
       610        620        630        640        650        660
VDALNAWRNA TVLKPEHSLA WNNMIILLDN TGNLAQAEAV GREALELIPN DHSLMFSLAN
       670        680        690        700        710        720
VLGKSQKYKE SEALFLKAIK ANPNAASYHG NLAVLYHRWG HLDLAKKHYE ISLQLDPTAS
       730        740
GTKENYGLLR RKLELMQKKA V

Isoforms

- Isoform 2 of Transmembrane and TPR repeat-containing protein 4 - Isoform 3 of Transmembrane and TPR repeat-containing protein 4 - Isoform 4 of Transmembrane and TPR repeat-containing protein 4 - Isoform 2 of Protein O-mannosyl-transferase TMTC4 - Isoform 3 of Protein O-mannosyl-transferase TMTC4 - Isoform 4 of Protein O-mannosyl-transferase TMTC4

Sequence View

        10         20         30         40         50         60
MAVLDTDLDH ILPSSVLPPF WAKLVVGSVA IVCFARSYDG DFVFDDSEAI VNNKDLQAET
        70         80         90        100        110        120
PLGDLWHHDF WGSRLSSNTS HKSYRPLTVL TFRINYYLSG GFHPVGFHVV NILLHSGISV
       130        140        150        160        170        180
LMVDVFSVLF GGLQYTSKGR RLHLAPRASL LAALLFAVHP VHTECVAGVV GRADLLCALF
       190        200        210        220        230        240
FLLSFLGYCK AFRESNKEGA HSSTFWVLLS IFLGAVAMLC KEQGITVLGL NAVFDILVIG
       250        260        270        280        290        300
KFNVLEIVQK VLHKDKSLEN LGMLRNGGLL FRMTLLTSGG AGMLYVRWRI MGTGPPAFTE
       310        320        330        340        350        360
VDNPASFADS MLVRAVNYNY YYSLNAWLLL CPWWLCFDWS MGCIPLIKSI SDWRVIALAA
       370        380        390        400        410        420
LWFCLIGLIC QALCSEDGHK RRILTLGLGF LVIPFLPASN LFFRVGFVVA ERVLYLPSVG
       430        440        450        460        470        480
YCVLLTFGFG ALSKHTKKKK LIAAVVLGIL FINTLRCVLR SGEWRSEEQL FRSALSVCPL
       490        500        510        520        530        540
NAKVHYNIGK NLADKGNQTA AIRYYREAVR LNPKYVHAMN NLGNILKERN ELQEAEELLS
       550        560        570        580        590        600
LAVQIQPDFA AAWMNLGIVQ NSLKRFEAAE QSYRTAIKHR RKYPDCYYNL GRLYADLNRH
       610        620        630        640        650        660
VDALNAWRNA TVLKPEHSLA WNNMIILLDN TGNLAQAEAV GREALELIPN DHSLMFSLAN
       670        680        690        700        710        720
VLGKSQKYKE SEALFLKAIK ANPNAASYHG NLAVLYHRWG HLDLAKKHYE ISLQLDPTAS
       730        740
GTKENYGLLR RKLELMQKKA V         10         20         30         40         50         60
MAVLDTDLDH ILPSSVLPPF WAKLVVGSVA IVCFARSYDG DFVFDDSEAI VNNKDLQAET
        70         80         90        100        110        120
PLGDLWHHDF WGSRLSSNTS HKSYRPLTVL TFRINYYLSG GFHPVGFHVV NILLHSGISV
       130        140        150        160        170        180
LMVDVFSVLF GGLQYTSKGR RLHLAPRASL LAALLFAVHP VHTECVAGVV GRADLLCALF
       190        200        210        220        230        240
FLLSFLGYCK AFRESNKEGA HSSTFWVLLS IFLGAVAMLC KEQGITVLGL NAVFDILVIG
       250        260        270        280        290        300
KFNVLEIVQK VLHKDKSLEN LGMLRNGGLL FRMTLLTSGG AGMLYVRWRI MGTGPPAFTE
       310        320        330        340        350        360
VDNPASFADS MLVRAVNYNY YYSLNAWLLL CPWWLCFDWS MGCIPLIKSI SDWRVIALAA
       370        380        390        400        410        420
LWFCLIGLIC QALCSEDGHK RRILTLGLGF LVIPFLPASN LFFRVGFVVA ERVLYLPSVG
       430        440        450        460        470        480
YCVLLTFGFG ALSKHTKKKK LIAAVVLGIL FINTLRCVLR SGEWRSEEQL FRSALSVCPL
       490        500        510        520        530        540
NAKVHYNIGK NLADKGNQTA AIRYYREAVR LNPKYVHAMN NLGNILKERN ELQEAEELLS
       550        560        570        580        590        600
LAVQIQPDFA AAWMNLGIVQ NSLKRFEAAE QSYRTAIKHR RKYPDCYYNL GRLYADLNRH
       610        620        630        640        650        660
VDALNAWRNA TVLKPEHSLA WNNMIILLDN TGNLAQAEAV GREALELIPN DHSLMFSLAN
       670        680        690        700        710        720
VLGKSQKYKE SEALFLKAIK ANPNAASYHG NLAVLYHRWG HLDLAKKHYE ISLQLDPTAS
       730        740
GTKENYGLLR RKLELMQKKA V         10         20         30         40         50         60
MAVLDTDLDH ILPSSVLPPF WAKLVVGSVA IVCFARSYDG DFVFDDSEAI VNNKDLQAET
        70         80         90        100        110        120
PLGDLWHHDF WGSRLSSNTS HKSYRPLTVL TFRINYYLSG GFHPVGFHVV NILLHSGISV
       130        140        150        160        170        180
LMVDVFSVLF GGLQYTSKGR RLHLAPRASL LAALLFAVHP VHTECVAGVV GRADLLCALF
       190        200        210        220        230        240
FLLSFLGYCK AFRESNKEGA HSSTFWVLLS IFLGAVAMLC KEQGITVLGL NAVFDILVIG
       250        260        270        280        290        300
KFNVLEIVQK VLHKDKSLEN LGMLRNGGLL FRMTLLTSGG AGMLYVRWRI MGTGPPAFTE
       310        320        330        340        350        360
VDNPASFADS MLVRAVNYNY YYSLNAWLLL CPWWLCFDWS MGCIPLIKSI SDWRVIALAA
       370        380        390        400        410        420
LWFCLIGLIC QALCSEDGHK RRILTLGLGF LVIPFLPASN LFFRVGFVVA ERVLYLPSVG
       430        440        450        460        470        480
YCVLLTFGFG ALSKHTKKKK LIAAVVLGIL FINTLRCVLR SGEWRSEEQL FRSALSVCPL
       490        500        510        520        530        540
NAKVHYNIGK NLADKGNQTA AIRYYREAVR LNPKYVHAMN NLGNILKERN ELQEAEELLS
       550        560        570        580        590        600
LAVQIQPDFA AAWMNLGIVQ NSLKRFEAAE QSYRTAIKHR RKYPDCYYNL GRLYADLNRH
       610        620        630        640        650        660
VDALNAWRNA TVLKPEHSLA WNNMIILLDN TGNLAQAEAV GREALELIPN DHSLMFSLAN
       670        680        690        700        710        720
VLGKSQKYKE SEALFLKAIK ANPNAASYHG NLAVLYHRWG HLDLAKKHYE ISLQLDPTAS
       730        740
GTKENYGLLR RKLELMQKKA V         10         20         30         40         50         60
MAVLDTDLDH ILPSSVLPPF WAKLVVGSVA IVCFARSYDG DFVFDDSEAI VNNKDLQAET
        70         80         90        100        110        120
PLGDLWHHDF WGSRLSSNTS HKSYRPLTVL TFRINYYLSG GFHPVGFHVV NILLHSGISV
       130        140        150        160        170        180
LMVDVFSVLF GGLQYTSKGR RLHLAPRASL LAALLFAVHP VHTECVAGVV GRADLLCALF
       190        200        210        220        230        240
FLLSFLGYCK AFRESNKEGA HSSTFWVLLS IFLGAVAMLC KEQGITVLGL NAVFDILVIG
       250        260        270        280        290        300
KFNVLEIVQK VLHKDKSLEN LGMLRNGGLL FRMTLLTSGG AGMLYVRWRI MGTGPPAFTE
       310        320        330        340        350        360
VDNPASFADS MLVRAVNYNY YYSLNAWLLL CPWWLCFDWS MGCIPLIKSI SDWRVIALAA
       370        380        390        400        410        420
LWFCLIGLIC QALCSEDGHK RRILTLGLGF LVIPFLPASN LFFRVGFVVA ERVLYLPSVG
       430        440        450        460        470        480
YCVLLTFGFG ALSKHTKKKK LIAAVVLGIL FINTLRCVLR SGEWRSEEQL FRSALSVCPL
       490        500        510        520        530        540
NAKVHYNIGK NLADKGNQTA AIRYYREAVR LNPKYVHAMN NLGNILKERN ELQEAEELLS
       550        560        570        580        590        600
LAVQIQPDFA AAWMNLGIVQ NSLKRFEAAE QSYRTAIKHR RKYPDCYYNL GRLYADLNRH
       610        620        630        640        650        660
VDALNAWRNA TVLKPEHSLA WNNMIILLDN TGNLAQAEAV GREALELIPN DHSLMFSLAN
       670        680        690        700        710        720
VLGKSQKYKE SEALFLKAIK ANPNAASYHG NLAVLYHRWG HLDLAKKHYE ISLQLDPTAS
       730        740
GTKENYGLLR RKLELMQKKA V         10         20         30         40         50         60
MAVLDTDLDH ILPSSVLPPF WAKLVVGSVA IVCFARSYDG DFVFDDSEAI VNNKDLQAET
        70         80         90        100        110        120
PLGDLWHHDF WGSRLSSNTS HKSYRPLTVL TFRINYYLSG GFHPVGFHVV NILLHSGISV
       130        140        150        160        170        180
LMVDVFSVLF GGLQYTSKGR RLHLAPRASL LAALLFAVHP VHTECVAGVV GRADLLCALF
       190        200        210        220        230        240
FLLSFLGYCK AFRESNKEGA HSSTFWVLLS IFLGAVAMLC KEQGITVLGL NAVFDILVIG
       250        260        270        280        290        300
KFNVLEIVQK VLHKDKSLEN LGMLRNGGLL FRMTLLTSGG AGMLYVRWRI MGTGPPAFTE
       310        320        330        340        350        360
VDNPASFADS MLVRAVNYNY YYSLNAWLLL CPWWLCFDWS MGCIPLIKSI SDWRVIALAA
       370        380        390        400        410        420
LWFCLIGLIC QALCSEDGHK RRILTLGLGF LVIPFLPASN LFFRVGFVVA ERVLYLPSVG
       430        440        450        460        470        480
YCVLLTFGFG ALSKHTKKKK LIAAVVLGIL FINTLRCVLR SGEWRSEEQL FRSALSVCPL
       490        500        510        520        530        540
NAKVHYNIGK NLADKGNQTA AIRYYREAVR LNPKYVHAMN NLGNILKERN ELQEAEELLS
       550        560        570        580        590        600
LAVQIQPDFA AAWMNLGIVQ NSLKRFEAAE QSYRTAIKHR RKYPDCYYNL GRLYADLNRH
       610        620        630        640        650        660
VDALNAWRNA TVLKPEHSLA WNNMIILLDN TGNLAQAEAV GREALELIPN DHSLMFSLAN
       670        680        690        700        710        720
VLGKSQKYKE SEALFLKAIK ANPNAASYHG NLAVLYHRWG HLDLAKKHYE ISLQLDPTAS
       730        740
GTKENYGLLR RKLELMQKKA V         10         20         30         40         50         60
MAVLDTDLDH ILPSSVLPPF WAKLVVGSVA IVCFARSYDG DFVFDDSEAI VNNKDLQAET
        70         80         90        100        110        120
PLGDLWHHDF WGSRLSSNTS HKSYRPLTVL TFRINYYLSG GFHPVGFHVV NILLHSGISV
       130        140        150        160        170        180
LMVDVFSVLF GGLQYTSKGR RLHLAPRASL LAALLFAVHP VHTECVAGVV GRADLLCALF
       190        200        210        220        230        240
FLLSFLGYCK AFRESNKEGA HSSTFWVLLS IFLGAVAMLC KEQGITVLGL NAVFDILVIG
       250        260        270        280        290        300
KFNVLEIVQK VLHKDKSLEN LGMLRNGGLL FRMTLLTSGG AGMLYVRWRI MGTGPPAFTE
       310        320        330        340        350        360
VDNPASFADS MLVRAVNYNY YYSLNAWLLL CPWWLCFDWS MGCIPLIKSI SDWRVIALAA
       370        380        390        400        410        420
LWFCLIGLIC QALCSEDGHK RRILTLGLGF LVIPFLPASN LFFRVGFVVA ERVLYLPSVG
       430        440        450        460        470        480
YCVLLTFGFG ALSKHTKKKK LIAAVVLGIL FINTLRCVLR SGEWRSEEQL FRSALSVCPL
       490        500        510        520        530        540
NAKVHYNIGK NLADKGNQTA AIRYYREAVR LNPKYVHAMN NLGNILKERN ELQEAEELLS
       550        560        570        580        590        600
LAVQIQPDFA AAWMNLGIVQ NSLKRFEAAE QSYRTAIKHR RKYPDCYYNL GRLYADLNRH
       610        620        630        640        650        660
VDALNAWRNA TVLKPEHSLA WNNMIILLDN TGNLAQAEAV GREALELIPN DHSLMFSLAN
       670        680        690        700        710        720
VLGKSQKYKE SEALFLKAIK ANPNAASYHG NLAVLYHRWG HLDLAKKHYE ISLQLDPTAS
       730        740
GTKENYGLLR RKLELMQKKA V

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q5T4D3-1-unknown	MAVLDT...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q5T4D3-1-unknown	MAVLDT...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt92570
Q5T4D3-1-unknown	MAVLDT...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt92572
Q5T4D3-1-unknown	MAVLDT...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt101778

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...IVNNKD	54	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000398400
...IVNNKD	54	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000419613
...IVNNKD	54	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt109284
...IVNNKD	54	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt109286
...IVNNKD	54	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt109285
...QKKAV	741	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...QKKAV	741	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt88190
...QKKAV	741	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt88189

TopFIND

Q5T4D3: Protein O-mannosyl-transferase TMTC4 {ECO:0000305}

General Information

1

N-termini

2

C-termini

0

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

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Lab:

Protein Neighborhood

Domains & Features

1 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates