Q5T5U3: Rho GTPase-activating protein 21
| Protein names | - Rho GTPase-activating protein 21 - Rho GTPase-activating protein 10 - Rho-type GTPase-activating protein 21 |
|---|---|
| Gene names | ARHGAP21 |
| Organism | Homo sapiens |
| Protease Family | |
| Protease ID | |
| Chromosome location | |
| UniProt ID | Q5T5U3 |
4
N-termini
2
C-termini
0
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MMATRRTGLS EGDGDKLKAC EVSKNKDGKE QSETVSLSED ETFSWPGPKT VTLKRTSQGF
70 80 90 100 110 120
GFTLRHFIVY PPESAIQFSY KDEENGNRGG KQRNRLEPMD TIFVKQVKEG GPAFEAGLCT
130 140 150 160 170 180
GDRIIKVNGE SVIGKTYSQV IALIQNSDTT LELSVMPKDE DILQVLQFTK DVTALAYSQD
190 200 210 220 230 240
AYLKGNEAYS GNARNIPEPP PICYPWLPSA PSAMAQPVEI SPPDSSLSKQ QTSTPVLTQP
250 260 270 280 290 300
GRAYRMEIQV PPSPTDVAKS NTAVCVCNES VRTVIVPSEK VVDLLSNRNN HTGPSHRTEE
310 320 330 340 350 360
VRYGVSEQTS LKTVSRTTSP PLSIPTTHLI HQPAGSRSLE PSGILLKSGN YSGHSDGISS
370 380 390 400 410 420
SRSQAVEAPS VSVNHYSPNS HQHIDWKNYK TYKEYIDNRR LHIGCRTIQE RLDSLRAASQ
430 440 450 460 470 480
STTDYNQVVP NRTTLQGRRR STSHDRVPQS VQIRQRSVSQ ERLEDSVLMK YCPRSASQGA
490 500 510 520 530 540
LTSPSVSFSN HRTRSWDYIE GQDETLENVN SGTPIPDSNG EKKQTYKWSG FTEQDDRRGI
550 560 570 580 590 600
CERPRQQEIH KSFRGSNFTV APSVVNSDNR RMSGRGVGSV SQFKKIPPDL KTLQSNRNFQ
610 620 630 640 650 660
TTCGMSLPRG ISQDRSPLVK VRSNSLKAPS THVTKPSFSQ KSFVSIKDQR PVNHLHQNSL
670 680 690 700 710 720
LNQQTWVRTD SAPDQQVETG KSPSLSGASA KPAPQSSENA GTSDLELPVS QRNQDLSLQE
730 740 750 760 770 780
AETEQSDTLD NKEAVILREK PPSGRQTPQP LRHQSYILAV NDQETGSDTT CWLPNDARRE
790 800 810 820 830 840
VHIKRMEERK ASSTSPPGDS LASIPFIDEP TSPSIDHDIA HIPASAVISA STSQVPSIAT
850 860 870 880 890 900
VPPCLTTSAP LIRRQLSHDH ESVGPPSLDA QPNSKTERSK SYDEGLDDYR EDAKLSFKHV
910 920 930 940 950 960
SSLKGIKIAD SQKSSEDSGS RKDSSSEVFS DAAKEGWLHF RPLVTDKGKR VGGSIRPWKQ
970 980 990 1000 1010 1020
MYVVLRGHSL YLYKDKREQT TPSEEEQPIS VNACLIDISY SETKRKNVFR LTTSDCECLF
1030 1040 1050 1060 1070 1080
QAEDRDDMLA WIKTIQESSN LNEEDTGVTN RDLISRRIKE YNNLMSKAEQ LPKTPRQSLS
1090 1100 1110 1120 1130 1140
IRQTLLGAKS EPKTQSPHSP KEESERKLLS KDDTSPPKDK GTWRKGIPSI MRKTFEKKPT
1150 1160 1170 1180 1190 1200
ATGTFGVRLD DCPPAHTNRY IPLIVDICCK LVEERGLEYT GIYRVPGNNA AISSMQEELN
1210 1220 1230 1240 1250 1260
KGMADIDIQD DKWRDLNVIS SLLKSFFRKL PEPLFTNDKY ADFIEANRKE DPLDRLKTLK
1270 1280 1290 1300 1310 1320
RLIHDLPEHH YETLKFLSAH LKTVAENSEK NKMEPRNLAI VFGPTLVRTS EDNMTHMVTH
1330 1340 1350 1360 1370 1380
MPDQYKIVET LIQHHDWFFT EEGAEEPLTT VQEESTVDSQ PVPNIDHLLT NIGRTGVSPG
1390 1400 1410 1420 1430 1440
DVSDSATSDS TKSKGSWGSG KDQYSRELLV SSIFAAASRK RKKPKEKAQP SSSEDELDNV
1450 1460 1470 1480 1490 1500
FFKKENVEQC HNDTKEESKK ESETLGRKQK IIIAKENSTR KDPSTTKDEK ISLGKESTPS
1510 1520 1530 1540 1550 1560
EEPSPPHNSK HNKSPTLSCR FAILKESPRS LLAQKSSHLE ETGSDSGTLL STSSQASLAR
1570 1580 1590 1600 1610 1620
FSMKKSTSPE TKHSEFLANV STITSDYSTT SSATYLTSLD SSRLSPEVQS VAESKGDEAD
1630 1640 1650 1660 1670 1680
DERSELISEG RPVETDSESE FPVFPTALTS ERLFRGKLQE VTKSSRRNSE GSELSCTEGS
1690 1700 1710 1720 1730 1740
LTSSLDSRRQ LFSSHKLIEC DTLSRKKSAR FKSDSGSLGD AKNEKEAPSL TKVFDVMKKG
1750 1760 1770 1780 1790 1800
KSTGSLLTPT RGESEKQEPT WKTKIADRLK LRPRAPADDM FGVGNHKVNA ETAKRKSIRR
1810 1820 1830 1840 1850 1860
RHTLGGHRDA TEISVLNFWK VHEQSGERES ELSAVNRLKP KCSAQDLSIS DWLARERLRT
1870 1880 1890 1900 1910 1920
STSDLSRGEI GDPQTENPST REIATTDTPL SLHCNTGSSS STLASTNRPL LSIPPQSPDQ
1930 1940 1950
INGESFQNVS KNASSAANAQ PHKLSETPGS KAEFHPCL
Isoforms
- Isoform 3 of Rho GTPase-activating protein 21 - Isoform 3 of Rho GTPase-activating protein 21Sequence View
10 20 30 40 50 60
MMATRRTGLS EGDGDKLKAC EVSKNKDGKE QSETVSLSED ETFSWPGPKT VTLKRTSQGF
70 80 90 100 110 120
GFTLRHFIVY PPESAIQFSY KDEENGNRGG KQRNRLEPMD TIFVKQVKEG GPAFEAGLCT
130 140 150 160 170 180
GDRIIKVNGE SVIGKTYSQV IALIQNSDTT LELSVMPKDE DILQVLQFTK DVTALAYSQD
190 200 210 220 230 240
AYLKGNEAYS GNARNIPEPP PICYPWLPSA PSAMAQPVEI SPPDSSLSKQ QTSTPVLTQP
250 260 270 280 290 300
GRAYRMEIQV PPSPTDVAKS NTAVCVCNES VRTVIVPSEK VVDLLSNRNN HTGPSHRTEE
310 320 330 340 350 360
VRYGVSEQTS LKTVSRTTSP PLSIPTTHLI HQPAGSRSLE PSGILLKSGN YSGHSDGISS
370 380 390 400 410 420
SRSQAVEAPS VSVNHYSPNS HQHIDWKNYK TYKEYIDNRR LHIGCRTIQE RLDSLRAASQ
430 440 450 460 470 480
STTDYNQVVP NRTTLQGRRR STSHDRVPQS VQIRQRSVSQ ERLEDSVLMK YCPRSASQGA
490 500 510 520 530 540
LTSPSVSFSN HRTRSWDYIE GQDETLENVN SGTPIPDSNG EKKQTYKWSG FTEQDDRRGI
550 560 570 580 590 600
CERPRQQEIH KSFRGSNFTV APSVVNSDNR RMSGRGVGSV SQFKKIPPDL KTLQSNRNFQ
610 620 630 640 650 660
TTCGMSLPRG ISQDRSPLVK VRSNSLKAPS THVTKPSFSQ KSFVSIKDQR PVNHLHQNSL
670 680 690 700 710 720
LNQQTWVRTD SAPDQQVETG KSPSLSGASA KPAPQSSENA GTSDLELPVS QRNQDLSLQE
730 740 750 760 770 780
AETEQSDTLD NKEAVILREK PPSGRQTPQP LRHQSYILAV NDQETGSDTT CWLPNDARRE
790 800 810 820 830 840
VHIKRMEERK ASSTSPPGDS LASIPFIDEP TSPSIDHDIA HIPASAVISA STSQVPSIAT
850 860 870 880 890 900
VPPCLTTSAP LIRRQLSHDH ESVGPPSLDA QPNSKTERSK SYDEGLDDYR EDAKLSFKHV
910 920 930 940 950 960
SSLKGIKIAD SQKSSEDSGS RKDSSSEVFS DAAKEGWLHF RPLVTDKGKR VGGSIRPWKQ
970 980 990 1000 1010 1020
MYVVLRGHSL YLYKDKREQT TPSEEEQPIS VNACLIDISY SETKRKNVFR LTTSDCECLF
1030 1040 1050 1060 1070 1080
QAEDRDDMLA WIKTIQESSN LNEEDTGVTN RDLISRRIKE YNNLMSKAEQ LPKTPRQSLS
1090 1100 1110 1120 1130 1140
IRQTLLGAKS EPKTQSPHSP KEESERKLLS KDDTSPPKDK GTWRKGIPSI MRKTFEKKPT
1150 1160 1170 1180 1190 1200
ATGTFGVRLD DCPPAHTNRY IPLIVDICCK LVEERGLEYT GIYRVPGNNA AISSMQEELN
1210 1220 1230 1240 1250 1260
KGMADIDIQD DKWRDLNVIS SLLKSFFRKL PEPLFTNDKY ADFIEANRKE DPLDRLKTLK
1270 1280 1290 1300 1310 1320
RLIHDLPEHH YETLKFLSAH LKTVAENSEK NKMEPRNLAI VFGPTLVRTS EDNMTHMVTH
1330 1340 1350 1360 1370 1380
MPDQYKIVET LIQHHDWFFT EEGAEEPLTT VQEESTVDSQ PVPNIDHLLT NIGRTGVSPG
1390 1400 1410 1420 1430 1440
DVSDSATSDS TKSKGSWGSG KDQYSRELLV SSIFAAASRK RKKPKEKAQP SSSEDELDNV
1450 1460 1470 1480 1490 1500
FFKKENVEQC HNDTKEESKK ESETLGRKQK IIIAKENSTR KDPSTTKDEK ISLGKESTPS
1510 1520 1530 1540 1550 1560
EEPSPPHNSK HNKSPTLSCR FAILKESPRS LLAQKSSHLE ETGSDSGTLL STSSQASLAR
1570 1580 1590 1600 1610 1620
FSMKKSTSPE TKHSEFLANV STITSDYSTT SSATYLTSLD SSRLSPEVQS VAESKGDEAD
1630 1640 1650 1660 1670 1680
DERSELISEG RPVETDSESE FPVFPTALTS ERLFRGKLQE VTKSSRRNSE GSELSCTEGS
1690 1700 1710 1720 1730 1740
LTSSLDSRRQ LFSSHKLIEC DTLSRKKSAR FKSDSGSLGD AKNEKEAPSL TKVFDVMKKG
1750 1760 1770 1780 1790 1800
KSTGSLLTPT RGESEKQEPT WKTKIADRLK LRPRAPADDM FGVGNHKVNA ETAKRKSIRR
1810 1820 1830 1840 1850 1860
RHTLGGHRDA TEISVLNFWK VHEQSGERES ELSAVNRLKP KCSAQDLSIS DWLARERLRT
1870 1880 1890 1900 1910 1920
STSDLSRGEI GDPQTENPST REIATTDTPL SLHCNTGSSS STLASTNRPL LSIPPQSPDQ
1930 1940 1950
INGESFQNVS KNASSAANAQ PHKLSETPGS KAEFHPCL
10 20 30 40 50 60
MMATRRTGLS EGDGDKLKAC EVSKNKDGKE QSETVSLSED ETFSWPGPKT VTLKRTSQGF
70 80 90 100 110 120
GFTLRHFIVY PPESAIQFSY KDEENGNRGG KQRNRLEPMD TIFVKQVKEG GPAFEAGLCT
130 140 150 160 170 180
GDRIIKVNGE SVIGKTYSQV IALIQNSDTT LELSVMPKDE DILQVLQFTK DVTALAYSQD
190 200 210 220 230 240
AYLKGNEAYS GNARNIPEPP PICYPWLPSA PSAMAQPVEI SPPDSSLSKQ QTSTPVLTQP
250 260 270 280 290 300
GRAYRMEIQV PPSPTDVAKS NTAVCVCNES VRTVIVPSEK VVDLLSNRNN HTGPSHRTEE
310 320 330 340 350 360
VRYGVSEQTS LKTVSRTTSP PLSIPTTHLI HQPAGSRSLE PSGILLKSGN YSGHSDGISS
370 380 390 400 410 420
SRSQAVEAPS VSVNHYSPNS HQHIDWKNYK TYKEYIDNRR LHIGCRTIQE RLDSLRAASQ
430 440 450 460 470 480
STTDYNQVVP NRTTLQGRRR STSHDRVPQS VQIRQRSVSQ ERLEDSVLMK YCPRSASQGA
490 500 510 520 530 540
LTSPSVSFSN HRTRSWDYIE GQDETLENVN SGTPIPDSNG EKKQTYKWSG FTEQDDRRGI
550 560 570 580 590 600
CERPRQQEIH KSFRGSNFTV APSVVNSDNR RMSGRGVGSV SQFKKIPPDL KTLQSNRNFQ
610 620 630 640 650 660
TTCGMSLPRG ISQDRSPLVK VRSNSLKAPS THVTKPSFSQ KSFVSIKDQR PVNHLHQNSL
670 680 690 700 710 720
LNQQTWVRTD SAPDQQVETG KSPSLSGASA KPAPQSSENA GTSDLELPVS QRNQDLSLQE
730 740 750 760 770 780
AETEQSDTLD NKEAVILREK PPSGRQTPQP LRHQSYILAV NDQETGSDTT CWLPNDARRE
790 800 810 820 830 840
VHIKRMEERK ASSTSPPGDS LASIPFIDEP TSPSIDHDIA HIPASAVISA STSQVPSIAT
850 860 870 880 890 900
VPPCLTTSAP LIRRQLSHDH ESVGPPSLDA QPNSKTERSK SYDEGLDDYR EDAKLSFKHV
910 920 930 940 950 960
SSLKGIKIAD SQKSSEDSGS RKDSSSEVFS DAAKEGWLHF RPLVTDKGKR VGGSIRPWKQ
970 980 990 1000 1010 1020
MYVVLRGHSL YLYKDKREQT TPSEEEQPIS VNACLIDISY SETKRKNVFR LTTSDCECLF
1030 1040 1050 1060 1070 1080
QAEDRDDMLA WIKTIQESSN LNEEDTGVTN RDLISRRIKE YNNLMSKAEQ LPKTPRQSLS
1090 1100 1110 1120 1130 1140
IRQTLLGAKS EPKTQSPHSP KEESERKLLS KDDTSPPKDK GTWRKGIPSI MRKTFEKKPT
1150 1160 1170 1180 1190 1200
ATGTFGVRLD DCPPAHTNRY IPLIVDICCK LVEERGLEYT GIYRVPGNNA AISSMQEELN
1210 1220 1230 1240 1250 1260
KGMADIDIQD DKWRDLNVIS SLLKSFFRKL PEPLFTNDKY ADFIEANRKE DPLDRLKTLK
1270 1280 1290 1300 1310 1320
RLIHDLPEHH YETLKFLSAH LKTVAENSEK NKMEPRNLAI VFGPTLVRTS EDNMTHMVTH
1330 1340 1350 1360 1370 1380
MPDQYKIVET LIQHHDWFFT EEGAEEPLTT VQEESTVDSQ PVPNIDHLLT NIGRTGVSPG
1390 1400 1410 1420 1430 1440
DVSDSATSDS TKSKGSWGSG KDQYSRELLV SSIFAAASRK RKKPKEKAQP SSSEDELDNV
1450 1460 1470 1480 1490 1500
FFKKENVEQC HNDTKEESKK ESETLGRKQK IIIAKENSTR KDPSTTKDEK ISLGKESTPS
1510 1520 1530 1540 1550 1560
EEPSPPHNSK HNKSPTLSCR FAILKESPRS LLAQKSSHLE ETGSDSGTLL STSSQASLAR
1570 1580 1590 1600 1610 1620
FSMKKSTSPE TKHSEFLANV STITSDYSTT SSATYLTSLD SSRLSPEVQS VAESKGDEAD
1630 1640 1650 1660 1670 1680
DERSELISEG RPVETDSESE FPVFPTALTS ERLFRGKLQE VTKSSRRNSE GSELSCTEGS
1690 1700 1710 1720 1730 1740
LTSSLDSRRQ LFSSHKLIEC DTLSRKKSAR FKSDSGSLGD AKNEKEAPSL TKVFDVMKKG
1750 1760 1770 1780 1790 1800
KSTGSLLTPT RGESEKQEPT WKTKIADRLK LRPRAPADDM FGVGNHKVNA ETAKRKSIRR
1810 1820 1830 1840 1850 1860
RHTLGGHRDA TEISVLNFWK VHEQSGERES ELSAVNRLKP KCSAQDLSIS DWLARERLRT
1870 1880 1890 1900 1910 1920
STSDLSRGEI GDPQTENPST REIATTDTPL SLHCNTGSSS STLASTNRPL LSIPPQSPDQ
1930 1940 1950
INGESFQNVS KNASSAANAQ PHKLSETPGS KAEFHPCL
Protein Neighborhood
Domains & Features
4 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| Q5T5U3-1-unknown | MMATRR... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| Q5T5U3-1-unknown | MMATRR... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt87637 | |||
| Q5T5U3-11-unknown | EGDGDK... | 11 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000400566 | |||
| Q5T5U3-11-unknown | EGDGDK... | 11 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt131267 | |||
| Q5T5U3-213-unknown | AMAQPV... | 213 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000365604 | |||
| Q5T5U3-213-unknown | AMAQPV... | 213 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt131269 | |||
| Q5T5U3-1159-unknown | RYIPLI... | 1159 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000402761 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...GIPSIM | 1130 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000405018 | |||
| ...EFHPCL | 1957 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|