TopFIND 4.0

Q5VV42: Threonylcarbamoyladenosine tRNA methylthiotransferase

General Information

Protein names
- Threonylcarbamoyladenosine tRNA methylthiotransferase
- 2.8.4.5 {ECO:0000250|UniProtKB:Q91WE6}
- CDK5 regulatory subunit-associated protein 1-like 1
- tRNA-t(6)A37 methylthiotransferase
Gene names CDKAL1
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q5VV42

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MPSASCDTLL DDIEDIVSQE DSKPQDRHFV RKDVVPKVRR RNTQKYLQEE ENSPPSDSTI 
        70         80         90        100        110        120 
PGIQKIWIRT WGCSHNNSDG EYMAGQLAAY GYKITENASD ADLWLLNSCT VKNPAEDHFR 
       130        140        150        160        170        180 
NSIKKAQEEN KKIVLAGCVP QAQPRQDYLK GLSIIGVQQI DRVVEVVEET IKGHSVRLLG 
       190        200        210        220        230        240 
QKKDNGRRLG GARLDLPKIR KNPLIEIISI NTGCLNACTY CKTKHARGNL ASYPIDELVD 
       250        260        270        280        290        300 
RAKQSFQEGV CEIWLTSEDT GAYGRDIGTN LPTLLWKLVE VIPEGAMLRL GMTNPPYILE 
       310        320        330        340        350        360 
HLEEMAKILN HPRVYAFLHI PVQSASDSVL MEMKREYCVA DFKRVVDFLK EKVPGITIAT 
       370        380        390        400        410        420 
DIICGFPGET DQDFQETVKL VEEYKFPSLF INQFYPRPGT PAAKMEQVPA QVKKQRTKDL 
       430        440        450        460        470        480 
SRVFHSYSPY DHKIGERQQV LVTEESFDSK FYVAHNQFYE QVLVPKNPAF MGKMVEVDIY 
       490        500        510        520        530        540 
ESGKHFMKGQ PVSDAKVYTP SISKPLAKGE VSGLTKDFRN GLGNQLSSGS HTSAASQCDS 
       550        560        570    
ASSRMVLPMP RLHQDCALRM SVGLALLGLL FAFFVKVYN

Isoforms

- Isoform 2 of Threonylcarbamoyladenosine tRNA methylthiotransferase - Isoform 3 of Threonylcarbamoyladenosine tRNA methylthiotransferase

Sequence View

        10         20         30         40         50         60 
MPSASCDTLL DDIEDIVSQE DSKPQDRHFV RKDVVPKVRR RNTQKYLQEE ENSPPSDSTI 
        70         80         90        100        110        120 
PGIQKIWIRT WGCSHNNSDG EYMAGQLAAY GYKITENASD ADLWLLNSCT VKNPAEDHFR 
       130        140        150        160        170        180 
NSIKKAQEEN KKIVLAGCVP QAQPRQDYLK GLSIIGVQQI DRVVEVVEET IKGHSVRLLG 
       190        200        210        220        230        240 
QKKDNGRRLG GARLDLPKIR KNPLIEIISI NTGCLNACTY CKTKHARGNL ASYPIDELVD 
       250        260        270        280        290        300 
RAKQSFQEGV CEIWLTSEDT GAYGRDIGTN LPTLLWKLVE VIPEGAMLRL GMTNPPYILE 
       310        320        330        340        350        360 
HLEEMAKILN HPRVYAFLHI PVQSASDSVL MEMKREYCVA DFKRVVDFLK EKVPGITIAT 
       370        380        390        400        410        420 
DIICGFPGET DQDFQETVKL VEEYKFPSLF INQFYPRPGT PAAKMEQVPA QVKKQRTKDL 
       430        440        450        460        470        480 
SRVFHSYSPY DHKIGERQQV LVTEESFDSK FYVAHNQFYE QVLVPKNPAF MGKMVEVDIY 
       490        500        510        520        530        540 
ESGKHFMKGQ PVSDAKVYTP SISKPLAKGE VSGLTKDFRN GLGNQLSSGS HTSAASQCDS 
       550        560        570    
ASSRMVLPMP RLHQDCALRM SVGLALLGLL FAFFVKVYN         10         20         30         40         50         60 
MPSASCDTLL DDIEDIVSQE DSKPQDRHFV RKDVVPKVRR RNTQKYLQEE ENSPPSDSTI 
        70         80         90        100        110        120 
PGIQKIWIRT WGCSHNNSDG EYMAGQLAAY GYKITENASD ADLWLLNSCT VKNPAEDHFR 
       130        140        150        160        170        180 
NSIKKAQEEN KKIVLAGCVP QAQPRQDYLK GLSIIGVQQI DRVVEVVEET IKGHSVRLLG 
       190        200        210        220        230        240 
QKKDNGRRLG GARLDLPKIR KNPLIEIISI NTGCLNACTY CKTKHARGNL ASYPIDELVD 
       250        260        270        280        290        300 
RAKQSFQEGV CEIWLTSEDT GAYGRDIGTN LPTLLWKLVE VIPEGAMLRL GMTNPPYILE 
       310        320        330        340        350        360 
HLEEMAKILN HPRVYAFLHI PVQSASDSVL MEMKREYCVA DFKRVVDFLK EKVPGITIAT 
       370        380        390        400        410        420 
DIICGFPGET DQDFQETVKL VEEYKFPSLF INQFYPRPGT PAAKMEQVPA QVKKQRTKDL 
       430        440        450        460        470        480 
SRVFHSYSPY DHKIGERQQV LVTEESFDSK FYVAHNQFYE QVLVPKNPAF MGKMVEVDIY 
       490        500        510        520        530        540 
ESGKHFMKGQ PVSDAKVYTP SISKPLAKGE VSGLTKDFRN GLGNQLSSGS HTSAASQCDS 
       550        560        570    
ASSRMVLPMP RLHQDCALRM SVGLALLGLL FAFFVKVYN



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Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q5VV42-1-unknown MPSASC... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q5VV42-1-unknown MPSASC... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt70120

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...VKVYN 579 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...VKVYN 579 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt65737

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)