TopFIND 4.0

Q5W0Q7: SUMO-specific isopeptidase USPL1

General Information

Protein names
- SUMO-specific isopeptidase USPL1
- 3.4.22.-
- Ubiquitin-specific peptidase-like protein 1
- USP-like 1
Gene names USPL1
Organism Homo sapiens
Protease Family C98.001
Protease ID C98.001
Chromosome location
UniProt ID Q5W0Q7

2

N-termini

1

C-termini

0

Cleavages

6

Substrates

Sequence

        10         20         30         40         50         60 
MMDSPKIGNG LPVIGPGTDI GISSLHMVGY LGKNFDSAKV PSDEYCPACR EKGKLKALKT 
        70         80         90        100        110        120 
YRISFQESIF LCEDLQCIYP LGSKSLNNLI SPDLEECHTP HKPQKRKSLE SSYKDSLLLA 
       130        140        150        160        170        180 
NSKKTRNYIA IDGGKVLNSK HNGEVYDETS SNLPDSSGQQ NPIRTADSLE RNEILEADTV 
       190        200        210        220        230        240 
DMATTKDPAT VDVSGTGRPS PQNEGCTSKL EMPLESKCTS FPQALCVQWK NAYALCWLDC 
       250        260        270        280        290        300 
ILSALVHSEE LKNTVTGLCS KEESIFWRLL TKYNQANTLL YTSQLSGVKD GDCKKLTSEI 
       310        320        330        340        350        360 
FAEIETCLNE VRDEIFISLQ PQLRCTLGDM ESPVFAFPLL LKLETHIEKL FLYSFSWDFE 
       370        380        390        400        410        420 
CSQCGHQYQN RHMKSLVTFT NVIPEWHPLN AAHFGPCNNC NSKSQIRKMV LEKVSPIFML 
       430        440        450        460        470        480 
HFVEGLPQND LQHYAFHFEG CLYQITSVIQ YRANNHFITW ILDADGSWLE CDDLKGPCSE 
       490        500        510        520        530        540 
RHKKFEVPAS EIHIVIWERK ISQVTDKEAA CLPLKKTNDQ HALSNEKPVS LTSCSVGDAA 
       550        560        570        580        590        600 
SAETASVTHP KDISVAPRTL SQDTAVTHGD HLLSGPKGLV DNILPLTLEE TIQKTASVSQ 
       610        620        630        640        650        660 
LNSEAFLLEN KPVAENTGIL KTNTLLSQES LMASSVSAPC NEKLIQDQFV DISFPSQVVN 
       670        680        690        700        710        720 
TNMQSVQLNT EDTVNTKSVN NTDATGLIQG VKSVEIEKDA QLKQFLTPKT EQLKPERVTS 
       730        740        750        760        770        780 
QVSNLKKKET TADSQTTTSK SLQNQSLKEN QKKPFVGSWV KGLISRGASF MPLCVSAHNR 
       790        800        810        820        830        840 
NTITDLQPSV KGVNNFGGFK TKGINQKASH VSKKARKSAS KPPPISKPPA GPPSSNGTAA 
       850        860        870        880        890        900 
HPHAHAASEV LEKSGSTSCG AQLNHSSYGN GISSANHEDL VEGQIHKLRL KLRKKLKAEK 
       910        920        930        940        950        960 
KKLAALMSSP QSRTVRSENL EQVPQDGSPN DCESIEDLLN ELPYPIDIAS ESACTTVPGV 
       970        980        990       1000       1010       1020 
SLYSSQTHEE ILAELLSPTP VSTELSENGE GDFRYLGMGD SHIPPPVPSE FNDVSQNTHL 
      1030       1040       1050       1060       1070       1080 
RQDHNYCSPT KKNPCEVQPD SLTNNACVRT LNLESPMKTD IFDEFFSSSA LNALANDTLD 
      1090    
LPHFDEYLFE NY

Isoforms

- Isoform 2 of SUMO-specific isopeptidase USPL1

Sequence View

        10         20         30         40         50         60 
MMDSPKIGNG LPVIGPGTDI GISSLHMVGY LGKNFDSAKV PSDEYCPACR EKGKLKALKT 
        70         80         90        100        110        120 
YRISFQESIF LCEDLQCIYP LGSKSLNNLI SPDLEECHTP HKPQKRKSLE SSYKDSLLLA 
       130        140        150        160        170        180 
NSKKTRNYIA IDGGKVLNSK HNGEVYDETS SNLPDSSGQQ NPIRTADSLE RNEILEADTV 
       190        200        210        220        230        240 
DMATTKDPAT VDVSGTGRPS PQNEGCTSKL EMPLESKCTS FPQALCVQWK NAYALCWLDC 
       250        260        270        280        290        300 
ILSALVHSEE LKNTVTGLCS KEESIFWRLL TKYNQANTLL YTSQLSGVKD GDCKKLTSEI 
       310        320        330        340        350        360 
FAEIETCLNE VRDEIFISLQ PQLRCTLGDM ESPVFAFPLL LKLETHIEKL FLYSFSWDFE 
       370        380        390        400        410        420 
CSQCGHQYQN RHMKSLVTFT NVIPEWHPLN AAHFGPCNNC NSKSQIRKMV LEKVSPIFML 
       430        440        450        460        470        480 
HFVEGLPQND LQHYAFHFEG CLYQITSVIQ YRANNHFITW ILDADGSWLE CDDLKGPCSE 
       490        500        510        520        530        540 
RHKKFEVPAS EIHIVIWERK ISQVTDKEAA CLPLKKTNDQ HALSNEKPVS LTSCSVGDAA 
       550        560        570        580        590        600 
SAETASVTHP KDISVAPRTL SQDTAVTHGD HLLSGPKGLV DNILPLTLEE TIQKTASVSQ 
       610        620        630        640        650        660 
LNSEAFLLEN KPVAENTGIL KTNTLLSQES LMASSVSAPC NEKLIQDQFV DISFPSQVVN 
       670        680        690        700        710        720 
TNMQSVQLNT EDTVNTKSVN NTDATGLIQG VKSVEIEKDA QLKQFLTPKT EQLKPERVTS 
       730        740        750        760        770        780 
QVSNLKKKET TADSQTTTSK SLQNQSLKEN QKKPFVGSWV KGLISRGASF MPLCVSAHNR 
       790        800        810        820        830        840 
NTITDLQPSV KGVNNFGGFK TKGINQKASH VSKKARKSAS KPPPISKPPA GPPSSNGTAA 
       850        860        870        880        890        900 
HPHAHAASEV LEKSGSTSCG AQLNHSSYGN GISSANHEDL VEGQIHKLRL KLRKKLKAEK 
       910        920        930        940        950        960 
KKLAALMSSP QSRTVRSENL EQVPQDGSPN DCESIEDLLN ELPYPIDIAS ESACTTVPGV 
       970        980        990       1000       1010       1020 
SLYSSQTHEE ILAELLSPTP VSTELSENGE GDFRYLGMGD SHIPPPVPSE FNDVSQNTHL 
      1030       1040       1050       1060       1070       1080 
RQDHNYCSPT KKNPCEVQPD SLTNNACVRT LNLESPMKTD IFDEFFSSSA LNALANDTLD 
      1090    
LPHFDEYLFE NY



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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 6 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q5W0Q7-1-unknown MMDSPK... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q5W0Q7-330-unknown MESPVF... 330 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt94001

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...LFENY 1092 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...LFENY 1092 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt89619

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates