Q5XG92: Carboxylesterase 4A

General Information

Protein names	- Carboxylesterase 4A - 3.1.1.-
Gene names	CES4A
Organism	Homo sapiens
Protease Family
Protease ID	S09.959
Chromosome location
UniProt ID	Q5XG92

5 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Carboxylesterase 4A - Isoform 3 of Carboxylesterase 4A - Isoform 4 of Carboxylesterase 4A - Isoform 5 of Carboxylesterase 4A - Isoform 6 of Carboxylesterase 4A - Isoform 7 of Carboxylesterase 4A

Sequence View

        10         20         30         40         50         60
MRWILCWSLT LCLMAQTALG ALHTKRPQVV TKYGTLQGKQ MHVGKTPIQV FLGVPFSRPP
        70         80         90        100        110        120
LGILRFAPPE PPEPWKGIRD ATTYPPGCLQ ESWGQLASMY VSTRERYKWL RFSEDCLYLN
       130        140        150        160        170        180
VYAPARAPGD PQLPVMVWFP GGAFIVGAAS SYEGSDLAAR EKVVLVFLQH RLGIFGFLST
       190        200        210        220        230        240
DDSHARGNWG LLDQMAALRW VQENIAAFGG DPGNVTLFGQ SAGAMSISGL MMSPLASGLF
       250        260        270        280        290        300
HRAISQSGTA LFRLFITSNP LKVAKKVAHL AGCNHNSTQI LVNCLRALSG TKVMRVSNKM
       310        320        330        340        350        360
RFLQLNFQRD PEEIIWSMSP VVDGVVIPDD PLVLLTQGKV SSVPYLLGVN NLEFNWLLPY
       370        380        390        400        410        420
IMKFPLNRQA MRKETITKML WSTRTLLNIT KEQVPLVVEE YLDNVNEHDW KMLRNRMMDI
       430        440        450        460        470        480
VQDATFVYAT LQTAHYHRDA GLPVYLYEFE HHARGIIVKP RTDGADHGDE MYFLFGGPFA
       490        500        510        520        530        540
TGLSMGKEKA LSLQMMKYWA NFARTGNPND GNLPCWPRYN KDEKYLQLDF TTRVGMKLKE
       550        560
KKMAFWMSLY QSQRPEKQRQ F         10         20         30         40         50         60
MRWILCWSLT LCLMAQTALG ALHTKRPQVV TKYGTLQGKQ MHVGKTPIQV FLGVPFSRPP
        70         80         90        100        110        120
LGILRFAPPE PPEPWKGIRD ATTYPPGCLQ ESWGQLASMY VSTRERYKWL RFSEDCLYLN
       130        140        150        160        170        180
VYAPARAPGD PQLPVMVWFP GGAFIVGAAS SYEGSDLAAR EKVVLVFLQH RLGIFGFLST
       190        200        210        220        230        240
DDSHARGNWG LLDQMAALRW VQENIAAFGG DPGNVTLFGQ SAGAMSISGL MMSPLASGLF
       250        260        270        280        290        300
HRAISQSGTA LFRLFITSNP LKVAKKVAHL AGCNHNSTQI LVNCLRALSG TKVMRVSNKM
       310        320        330        340        350        360
RFLQLNFQRD PEEIIWSMSP VVDGVVIPDD PLVLLTQGKV SSVPYLLGVN NLEFNWLLPY
       370        380        390        400        410        420
IMKFPLNRQA MRKETITKML WSTRTLLNIT KEQVPLVVEE YLDNVNEHDW KMLRNRMMDI
       430        440        450        460        470        480
VQDATFVYAT LQTAHYHRDA GLPVYLYEFE HHARGIIVKP RTDGADHGDE MYFLFGGPFA
       490        500        510        520        530        540
TGLSMGKEKA LSLQMMKYWA NFARTGNPND GNLPCWPRYN KDEKYLQLDF TTRVGMKLKE
       550        560
KKMAFWMSLY QSQRPEKQRQ F         10         20         30         40         50         60
MRWILCWSLT LCLMAQTALG ALHTKRPQVV TKYGTLQGKQ MHVGKTPIQV FLGVPFSRPP
        70         80         90        100        110        120
LGILRFAPPE PPEPWKGIRD ATTYPPGCLQ ESWGQLASMY VSTRERYKWL RFSEDCLYLN
       130        140        150        160        170        180
VYAPARAPGD PQLPVMVWFP GGAFIVGAAS SYEGSDLAAR EKVVLVFLQH RLGIFGFLST
       190        200        210        220        230        240
DDSHARGNWG LLDQMAALRW VQENIAAFGG DPGNVTLFGQ SAGAMSISGL MMSPLASGLF
       250        260        270        280        290        300
HRAISQSGTA LFRLFITSNP LKVAKKVAHL AGCNHNSTQI LVNCLRALSG TKVMRVSNKM
       310        320        330        340        350        360
RFLQLNFQRD PEEIIWSMSP VVDGVVIPDD PLVLLTQGKV SSVPYLLGVN NLEFNWLLPY
       370        380        390        400        410        420
IMKFPLNRQA MRKETITKML WSTRTLLNIT KEQVPLVVEE YLDNVNEHDW KMLRNRMMDI
       430        440        450        460        470        480
VQDATFVYAT LQTAHYHRDA GLPVYLYEFE HHARGIIVKP RTDGADHGDE MYFLFGGPFA
       490        500        510        520        530        540
TGLSMGKEKA LSLQMMKYWA NFARTGNPND GNLPCWPRYN KDEKYLQLDF TTRVGMKLKE
       550        560
KKMAFWMSLY QSQRPEKQRQ F         10         20         30         40         50         60
MRWILCWSLT LCLMAQTALG ALHTKRPQVV TKYGTLQGKQ MHVGKTPIQV FLGVPFSRPP
        70         80         90        100        110        120
LGILRFAPPE PPEPWKGIRD ATTYPPGCLQ ESWGQLASMY VSTRERYKWL RFSEDCLYLN
       130        140        150        160        170        180
VYAPARAPGD PQLPVMVWFP GGAFIVGAAS SYEGSDLAAR EKVVLVFLQH RLGIFGFLST
       190        200        210        220        230        240
DDSHARGNWG LLDQMAALRW VQENIAAFGG DPGNVTLFGQ SAGAMSISGL MMSPLASGLF
       250        260        270        280        290        300
HRAISQSGTA LFRLFITSNP LKVAKKVAHL AGCNHNSTQI LVNCLRALSG TKVMRVSNKM
       310        320        330        340        350        360
RFLQLNFQRD PEEIIWSMSP VVDGVVIPDD PLVLLTQGKV SSVPYLLGVN NLEFNWLLPY
       370        380        390        400        410        420
IMKFPLNRQA MRKETITKML WSTRTLLNIT KEQVPLVVEE YLDNVNEHDW KMLRNRMMDI
       430        440        450        460        470        480
VQDATFVYAT LQTAHYHRDA GLPVYLYEFE HHARGIIVKP RTDGADHGDE MYFLFGGPFA
       490        500        510        520        530        540
TGLSMGKEKA LSLQMMKYWA NFARTGNPND GNLPCWPRYN KDEKYLQLDF TTRVGMKLKE
       550        560
KKMAFWMSLY QSQRPEKQRQ F         10         20         30         40         50         60
MRWILCWSLT LCLMAQTALG ALHTKRPQVV TKYGTLQGKQ MHVGKTPIQV FLGVPFSRPP
        70         80         90        100        110        120
LGILRFAPPE PPEPWKGIRD ATTYPPGCLQ ESWGQLASMY VSTRERYKWL RFSEDCLYLN
       130        140        150        160        170        180
VYAPARAPGD PQLPVMVWFP GGAFIVGAAS SYEGSDLAAR EKVVLVFLQH RLGIFGFLST
       190        200        210        220        230        240
DDSHARGNWG LLDQMAALRW VQENIAAFGG DPGNVTLFGQ SAGAMSISGL MMSPLASGLF
       250        260        270        280        290        300
HRAISQSGTA LFRLFITSNP LKVAKKVAHL AGCNHNSTQI LVNCLRALSG TKVMRVSNKM
       310        320        330        340        350        360
RFLQLNFQRD PEEIIWSMSP VVDGVVIPDD PLVLLTQGKV SSVPYLLGVN NLEFNWLLPY
       370        380        390        400        410        420
IMKFPLNRQA MRKETITKML WSTRTLLNIT KEQVPLVVEE YLDNVNEHDW KMLRNRMMDI
       430        440        450        460        470        480
VQDATFVYAT LQTAHYHRDA GLPVYLYEFE HHARGIIVKP RTDGADHGDE MYFLFGGPFA
       490        500        510        520        530        540
TGLSMGKEKA LSLQMMKYWA NFARTGNPND GNLPCWPRYN KDEKYLQLDF TTRVGMKLKE
       550        560
KKMAFWMSLY QSQRPEKQRQ F         10         20         30         40         50         60
MRWILCWSLT LCLMAQTALG ALHTKRPQVV TKYGTLQGKQ MHVGKTPIQV FLGVPFSRPP
        70         80         90        100        110        120
LGILRFAPPE PPEPWKGIRD ATTYPPGCLQ ESWGQLASMY VSTRERYKWL RFSEDCLYLN
       130        140        150        160        170        180
VYAPARAPGD PQLPVMVWFP GGAFIVGAAS SYEGSDLAAR EKVVLVFLQH RLGIFGFLST
       190        200        210        220        230        240
DDSHARGNWG LLDQMAALRW VQENIAAFGG DPGNVTLFGQ SAGAMSISGL MMSPLASGLF
       250        260        270        280        290        300
HRAISQSGTA LFRLFITSNP LKVAKKVAHL AGCNHNSTQI LVNCLRALSG TKVMRVSNKM
       310        320        330        340        350        360
RFLQLNFQRD PEEIIWSMSP VVDGVVIPDD PLVLLTQGKV SSVPYLLGVN NLEFNWLLPY
       370        380        390        400        410        420
IMKFPLNRQA MRKETITKML WSTRTLLNIT KEQVPLVVEE YLDNVNEHDW KMLRNRMMDI
       430        440        450        460        470        480
VQDATFVYAT LQTAHYHRDA GLPVYLYEFE HHARGIIVKP RTDGADHGDE MYFLFGGPFA
       490        500        510        520        530        540
TGLSMGKEKA LSLQMMKYWA NFARTGNPND GNLPCWPRYN KDEKYLQLDF TTRVGMKLKE
       550        560
KKMAFWMSLY QSQRPEKQRQ F

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q5XG92-1-unknown	MRWILC...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt74241
Q5XG92-1-unknown	MRWILC...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt74236
Q5XG92-1-unknown	MRWILC...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt74238
Q5XG92-21-unknown	ALHTKR...	21	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q5XG92-21-unknown	ALHTKR...	21	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112817
Q5XG92-21-unknown	ALHTKR...	21	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112818
Q5XG92-21-unknown	ALHTKR...	21	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112819
Q5XG92-38-unknown	GKQMHV...	38	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000441103
Q5XG92-38-unknown	GKQMHV...	38	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt195835
Q5XG92-38-unknown	GKQMHV...	38	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt195836
Q5XG92-38-unknown	GKQMHV...	38	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt195837
Q5XG92-99-unknown	MYVSTR...	99	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt74240
Q5XG92-99-unknown	MYVSTR...	99	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt74239
Q5XG92-99-unknown	MYVSTR...	99	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000441907
Q5XG92-99-unknown	MYVSTR...	99	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000441644
Q5XG92-99-unknown	MYVSTR...	99	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt95757
Q5XG92-99-unknown	MYVSTR...	99	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt95758
Q5XG92-99-unknown	MYVSTR...	99	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt95756
Q5XG92-195-unknown	MAALRW...	195	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt74237
Q5XG92-195-unknown	MAALRW...	195	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt109896
Q5XG92-195-unknown	MAALRW...	195	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt109895
Q5XG92-195-unknown	MAALRW...	195	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt109897
Q5XG92-195-unknown	MAALRW...	195	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt109898
Q5XG92-195-unknown	MAALRW...	195	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt109894

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KQRQF	561	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KQRQF	561	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69855
...KQRQF	561	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69857
...KQRQF	561	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69854

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)