Q61144: Presenilin-2

General Information

Protein names	- Presenilin-2 - PS-2 - 3.4.23.- - Presenilin-2 NTF subunit - Presenilin-2 CTF subunit
Gene names	Psen2
Organism	Mus musculus
Protease Family
Protease ID	A22.002
Chromosome location
UniProt ID	Q61144

2 N-termini

3 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MLAFMASDSE EEVCDERTSL MSAESPTSRS CQEGRPGPED GESTAQWRTQ ESEEDCEEDP
        70         80         90        100        110        120
DRYACSGAPG RPSGLEEELT LKYGAKRVIM LFVPVTLCMI VVVATIKSVR FYTEKNGQLI
       130        140        150        160        170        180
YTPFTEDTPS VGQRLLNSVL NTLIMISVIV VMTIFLVVLY KYRCYKFIHG WLIMSSLMLL
       190        200        210        220        230        240
FLFTYIYLGE VLKTYNVAMD YPTLFLAVWN FGAVGMVCIH WKGPLVLQQA YLIVISALMA
       250        260        270        280        290        300
LVFIKYLPEW SAWVILGAIS VYDLVAVLCP KGPLRMLVET AQERNEPIFP ALIYSSAMVW
       310        320        330        340        350        360
TVGMAKLDPS SQGALQLPYD PEMEEDSYDS FGEPSYPEAF EAPLPGYPGE ELEEEEERGV
       370        380        390        400        410        420
KLGLGDFIFY SVLVGKAAAT GNGDWNTTLA CFIAILIGLC LTLLLLAVFK KALPALPISI
       430        440
TFGLIFYFST DNLVRPFMDT LASHQLYI

Isoforms

- Isoform 2 of Presenilin-2

Sequence View

Protein Neighborhood

Domains & Features

2 N-termini - 3 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q61144-1-unknown	MLAFMA...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q61144-1-unknown	MLAFMA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt86422
Q61144-298-unknown	MVWTVG...	298	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q61144-298-unknown	MVWTVG...	298	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RPGPED	39	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000120216
...RPGPED	39	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt118150
...IYSSAM	297	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...HQLYI	448	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

TopFIND

Q61144: Presenilin-2

General Information

2

N-termini

3

C-termini

0

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

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Protein Neighborhood

Domains & Features

2 N-termini - 3 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates