Q61183: Poly(A) polymerase alpha

General Information

Protein names	- Poly(A) polymerase alpha - PAP-alpha - 2.7.7.19 - Polynucleotide adenylyltransferase
Gene names	Papola
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q61183

2 N-termini

3 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Poly(A) polymerase alpha - Isoform 3 of Poly(A) polymerase alpha - Isoform 4 of Poly(A) polymerase alpha

Sequence View

        10         20         30         40         50         60
MPFPVTTQGS QQTQPPQRHY GITSPISLAA PKETDCLLTQ KLIETLKPFG VFEEEEELQR
        70         80         90        100        110        120
RILILGKLNN LVKEWIREIS ESKNLPQSVI ENVGGKIFTF GSYRLGVHTK GADIDALCVA
       130        140        150        160        170        180
PRHVDRSDFF TSFYDKLKLQ EEVKDLRAVE EAFVPVIKLC FDGIEIDILF ARLALQTIPE
       190        200        210        220        230        240
DLDLRDDSLL KNLDIRCIRS LNGCRVTDEI LHLVPNIDNF RLTLRAIKLW AKRHNIYSNI
       250        260        270        280        290        300
LGFLGGVSWA MLVARTCQLY PNAIASTLVH KFFLVFSKWE WPNPVLLKQP EECNLNLPVW
       310        320        330        340        350        360
DPRVNPSDRY HLMPIITPAY PQQNSTYNVS VSTRMVMVEE FKQGLAITDE ILLSKAEWSK
       370        380        390        400        410        420
LFEAPNFFQK YKHYIVLLAS APTEKQRLEW VGLVESKIRI LVGSLEKNEF ITLAHVNPQS
       430        440        450        460        470        480
FPAPKESPDR EEFRTMWVIG LVFKKTENSE NLSVDLTYDI QSFTDTVYRQ AINSKMFELD
       490        500        510        520        530        540
MKIAAMHVKR KQLHQLLPSH VLQKRKKHST EGVKLTALND SSLDLSMDSD NSMSVPSPTS
       550        560        570        580        590        600
AMKTSPLNSS GSSQGRNSPA PAVTAASVTS IQASEVSVPQ ANSSESPGGP SSESIPQTAT
       610        620        630        640        650        660
QPAISPPPKP TVSRVVSSTR LVNPSPRPSG NTATKVPNPI VGVKRTSSPN KEESPKKTKT
       670        680        690        700        710        720
EEDETSEDAN CLALSGHDKT ETKEQVDLET SAVQSETVPA SASLLASQKT SSTDLSDIPA
       730
LPANPIPVIK NSIKLRLNR         10         20         30         40         50         60
MPFPVTTQGS QQTQPPQRHY GITSPISLAA PKETDCLLTQ KLIETLKPFG VFEEEEELQR
        70         80         90        100        110        120
RILILGKLNN LVKEWIREIS ESKNLPQSVI ENVGGKIFTF GSYRLGVHTK GADIDALCVA
       130        140        150        160        170        180
PRHVDRSDFF TSFYDKLKLQ EEVKDLRAVE EAFVPVIKLC FDGIEIDILF ARLALQTIPE
       190        200        210        220        230        240
DLDLRDDSLL KNLDIRCIRS LNGCRVTDEI LHLVPNIDNF RLTLRAIKLW AKRHNIYSNI
       250        260        270        280        290        300
LGFLGGVSWA MLVARTCQLY PNAIASTLVH KFFLVFSKWE WPNPVLLKQP EECNLNLPVW
       310        320        330        340        350        360
DPRVNPSDRY HLMPIITPAY PQQNSTYNVS VSTRMVMVEE FKQGLAITDE ILLSKAEWSK
       370        380        390        400        410        420
LFEAPNFFQK YKHYIVLLAS APTEKQRLEW VGLVESKIRI LVGSLEKNEF ITLAHVNPQS
       430        440        450        460        470        480
FPAPKESPDR EEFRTMWVIG LVFKKTENSE NLSVDLTYDI QSFTDTVYRQ AINSKMFELD
       490        500        510        520        530        540
MKIAAMHVKR KQLHQLLPSH VLQKRKKHST EGVKLTALND SSLDLSMDSD NSMSVPSPTS
       550        560        570        580        590        600
AMKTSPLNSS GSSQGRNSPA PAVTAASVTS IQASEVSVPQ ANSSESPGGP SSESIPQTAT
       610        620        630        640        650        660
QPAISPPPKP TVSRVVSSTR LVNPSPRPSG NTATKVPNPI VGVKRTSSPN KEESPKKTKT
       670        680        690        700        710        720
EEDETSEDAN CLALSGHDKT ETKEQVDLET SAVQSETVPA SASLLASQKT SSTDLSDIPA
       730
LPANPIPVIK NSIKLRLNR         10         20         30         40         50         60
MPFPVTTQGS QQTQPPQRHY GITSPISLAA PKETDCLLTQ KLIETLKPFG VFEEEEELQR
        70         80         90        100        110        120
RILILGKLNN LVKEWIREIS ESKNLPQSVI ENVGGKIFTF GSYRLGVHTK GADIDALCVA
       130        140        150        160        170        180
PRHVDRSDFF TSFYDKLKLQ EEVKDLRAVE EAFVPVIKLC FDGIEIDILF ARLALQTIPE
       190        200        210        220        230        240
DLDLRDDSLL KNLDIRCIRS LNGCRVTDEI LHLVPNIDNF RLTLRAIKLW AKRHNIYSNI
       250        260        270        280        290        300
LGFLGGVSWA MLVARTCQLY PNAIASTLVH KFFLVFSKWE WPNPVLLKQP EECNLNLPVW
       310        320        330        340        350        360
DPRVNPSDRY HLMPIITPAY PQQNSTYNVS VSTRMVMVEE FKQGLAITDE ILLSKAEWSK
       370        380        390        400        410        420
LFEAPNFFQK YKHYIVLLAS APTEKQRLEW VGLVESKIRI LVGSLEKNEF ITLAHVNPQS
       430        440        450        460        470        480
FPAPKESPDR EEFRTMWVIG LVFKKTENSE NLSVDLTYDI QSFTDTVYRQ AINSKMFELD
       490        500        510        520        530        540
MKIAAMHVKR KQLHQLLPSH VLQKRKKHST EGVKLTALND SSLDLSMDSD NSMSVPSPTS
       550        560        570        580        590        600
AMKTSPLNSS GSSQGRNSPA PAVTAASVTS IQASEVSVPQ ANSSESPGGP SSESIPQTAT
       610        620        630        640        650        660
QPAISPPPKP TVSRVVSSTR LVNPSPRPSG NTATKVPNPI VGVKRTSSPN KEESPKKTKT
       670        680        690        700        710        720
EEDETSEDAN CLALSGHDKT ETKEQVDLET SAVQSETVPA SASLLASQKT SSTDLSDIPA
       730
LPANPIPVIK NSIKLRLNR

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 3 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q61183-1-unknown	MPFPVT...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q61183-1-unknown	MPFPVT...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt84249
Q61183-1-unknown	MPFPVT...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt84250
Q61183-1-unknown	MPFPVT...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt84251
Q61183-251-unknown	MLVART...	251	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000130714
Q61183-251-unknown	MLVART...	251	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt198462
Q61183-251-unknown	MLVART...	251	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt198463
Q61183-251-unknown	MLVART...	251	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt198464

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VHKFFL	273	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000130714
...SSPNKE	651	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000125898
...LRLNR	739	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LRLNR	739	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79869
...LRLNR	739	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79868

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)