TopFIND 4.0

Q62226: Sonic hedgehog protein

General Information

Protein names
- Sonic hedgehog protein
- SHH
- HHG-1
- Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains {ECO:0000303|PubMed:24522195}
- ShhNC {ECO:0000303|PubMed:24522195}
- Sonic hedgehog protein N-product
- ShhN
- Shh N-terminal processed signaling domains {ECO:0000303|PubMed:24522195}
- ShhNp {ECO:0000303|PubMed:24522195}
- Sonic hedgehog protein 19 kDa product
Gene names Shh
Organism Mus musculus
Protease Family
Protease ID C46.002
Chromosome location
UniProt ID Q62226

2

N-termini

2

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MLLLLARCFL VILASSLLVC PGLACGPGRG FGKRRHPKKL TPLAYKQFIP NVAEKTLGAS 
        70         80         90        100        110        120 
GRYEGKITRN SERFKELTPN YNPDIIFKDE ENTGADRLMT QRCKDKLNAL AISVMNQWPG 
       130        140        150        160        170        180 
VKLRVTEGWD EDGHHSEESL HYEGRAVDIT TSDRDRSKYG MLARLAVEAG FDWVYYESKA 
       190        200        210        220        230        240 
HIHCSVKAEN SVAAKSGGCF PGSATVHLEQ GGTKLVKDLR PGDRVLAADD QGRLLYSDFL 
       250        260        270        280        290        300 
TFLDRDEGAK KVFYVIETLE PRERLLLTAA HLLFVAPHND SGPTPGPSAL FASRVRPGQR 
       310        320        330        340        350        360 
VYVVAERGGD RRLLPAAVHS VTLREEEAGA YAPLTAHGTI LINRVLASCY AVIEEHSWAH 
       370        380        390        400        410        420 
RAFAPFRLAH ALLAALAPAR TDGGGGGSIP AAQSATEARG AEPTAGIHWY SQLLYHIGTW 
       430    
LLDSETMHPL GMAVKSS

Isoforms



Sequence View



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Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q62226-25-unknown CGPGRG... 25 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q62226-199-unknown CFPGSA... 199 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...AKSGGC 198 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...AVKSS 437 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)