TopFIND 4.0

Q63185: Eukaryotic translation initiation factor 2-alpha kinase 1

General Information

Protein names
- Eukaryotic translation initiation factor 2-alpha kinase 1
- 2.7.11.1
- Heme-controlled repressor
- HCR
- Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase
- Heme-regulated inhibitor
- Hemin-sensitive initiation factor 2-alpha kinase
Gene names Eif2ak1
Organism Rattus norvegicus
Protease Family
Protease ID
Chromosome location
UniProt ID Q63185

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MLGGGSVDGE RDTDDDAAGA VAAPPAIDFP AEVSDPKYDE SDVPAELQVF KEPLQQPTFP 
        70         80         90        100        110        120 
FLVANQLLLV SLLEHLSHVH EPNPLHSKQV FKLLCQTFIK MGLLSSFTCS DEFSSLRLHH 
       130        140        150        160        170        180 
NRAITHLMRS AKERVRQDPC QDNSYMQKIR SREIALEAQT SRYLNEFEEL AILGKGGYGR 
       190        200        210        220        230        240 
VYKVRNKLDG QHYAIKKILI KSATKTDCMK VLREVKVLAG LQHPNIVGYH TAWIEHVHVL 
       250        260        270        280        290        300 
QPQDRVPIQL PSLEVLSEHE GDRNQGGVKD NESSSSIIFA ELTPEKENPL AESDVKNENN 
       310        320        330        340        350        360 
NLVSYRANLV IRSSSESESS IELQEDGLNE SPLRPVVKHQ LPLGHSSDVE GNFTSTDESS 
       370        380        390        400        410        420 
EDNLNLLGQT EARYHLMLHI QMQLCELSLW DWIAERNNRS RECVDEAACP YVMASVATKI 
       430        440        450        460        470        480 
FQELVEGVFY IHNMGIVHRD LKPRNIFLHG PDQQVKIGDF GLACADIIQK SADWTNRNGK 
       490        500        510        520        530        540 
GTPTHTSRVG TCLYASPEQL EGSEYDAKSD MYSLGVILLE LFQPFGTEME RATVLTGVRT 
       550        560        570        580        590        600 
GRIPESLSKR CPVQAKYIQL LTGRNAAQRP SALQLLQSEL FQTTGNVNLT LQMKIMEQEK 
       610        620    
EIEELKKQLS LLSQDKGLKR 

Isoforms



Sequence View



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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q63185-1-unknown MLGGGS... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...KGLKR 620 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)