Q64535: Copper-transporting ATPase 2

General Information

Protein names	- Copper-transporting ATPase 2 - 7.2.2.8 {ECO:0000250\|UniProtKB:P35670} - Copper pump 2 - Pineal night-specific ATPase - Wilson disease-associated protein homolog
Gene names	Atp7b
Organism	Rattus norvegicus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q64535

3 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPEQERKVTA KEASRKILSK LALPTRPWGQ SMKQSFAFDN VGYEGGLDST CFILQLTTGV
        70         80         90        100        110        120
VSILGMTCHS CVKSIEDRIS SLKGIVSIKV SLEQGSATVK YVPSVLNLQQ ICLQIEDMGF
       130        140        150        160        170        180
EASAAEGKAA SWPSRSSPAQ EAVVKLRVEG MTCQSCVSSI EGKIRKLQGV VRVKVSLSNQ
       190        200        210        220        230        240
EAVITYQPYL IQPEDLRDHI CDMGFEAAIK NRTAPLRLGP IDINKLESTN LKRAAVPPIQ
       250        260        270        280        290        300
NSNHLETPGH QQNHLATLPL RIDGMHCKSC VLNIEGNIGQ LPGVQNIHVS LENKTAQVQY
       310        320        330        340        350        360
DSSCITPLFL QTAIEALPPG YFKVSLPDGL EKESGSSSVP SLGSSQRQQE PGPCRTAVLT
       370        380        390        400        410        420
ITGIPRDSSV QPMEDMLSQM KGVQQIDISL AEGTGAVLYD PSVVSSDELR TAVEDMGFEV
       430        440        450        460        470        480
SVNPENITTN RVSSGNSVPQ AVGDSPGSVQ NMASDTRGLL THQGPGYLSD SPPSPGGTAS
       490        500        510        520        530        540
QKCFVQIKGM TCASCVSNIE RSLQRHAGIL SVLVALMSGK AEVKYDPEVI QSPRIAQLIE
       550        560        570        580        590        600
DLGFEAAIME DNTVSEGDIE LIITGMTCAS CVHNIESKLT RTNGITYASV ALATSKAHVK
       610        620        630        640        650        660
FDPEIIGPRD IIKVIEEIGF HASLAHRNPN AHHLDHKTEI KQWKKSFLCS LVFGIPVMGL
       670        680        690        700        710        720
MIYMLIPSSK PHETMVLDHN IIPGLSVLNL IFFILCTFVQ FLGGWYFYVQ AYKSLRHKSA
       730        740        750        760        770        780
NMDVLIVLAT TIAYAYSLVI LVVAIAEKAE KSPVTFFDTP PMLFVFIALG RWLEHVAKSK
       790        800        810        820        830        840
TSEALAKLMS LQATEATVVT LGEDNLILRE EQVPMELVQR GDIIKVVPGG KFPVDGKVLE
       850        860        870        880        890        900
GNTMADESLI TGEAMPVTKK PGSIVIAGSI NAHGSVLIKA THVGNDTTLA QIVKLVEEAQ
       910        920        930        940        950        960
MSKAPIQQLA DRFSGYFVPF IIIISTLTLV VWIIIGFVDF GIVQKYFPSP SKHISQTEVI
       970        980        990       1000       1010       1020
IRFAFQTSIT VLCIACPCSL GLATPTAVMV GTGVAAQNGV LIKGGKPLEM AHKIKTVMFD
      1030       1040       1050       1060       1070       1080
KTGTITHGVP RVMRFLLLVD VATLSLRKVL AVVGTAEASS EHPLGVAVTK YCKEELGTET
      1090       1100       1110       1120       1130       1140
LGYSTDFQAV PGCGISCKVS NVESILAHRG PTAHPIGVGN PPIGEGTGPQ TFSVLIGNRE
      1150       1160       1170       1180       1190       1200
WMRRNGLTIS SDISDAMTDH EMKGQTAILV AIDGVLCGMI AIADAVKPEA ALASITLKSM
      1210       1220       1230       1240       1250       1260
GVDVALITGD NRKTARAIAT QVGINKVFAE VLPSHKVAKV QELQNKGKKV AMVGDGVNDS
      1270       1280       1290       1300       1310       1320
PALAQADVGI AIGTGTDVAI DAADVVLIRN DLLDVVASIH LSKRTVRRIR VNLVLALIYN
      1330       1340       1350       1360       1370       1380
MVGIPIAAGV FMPIGIVLQP WMGSAAASSV SVVLSSLQLK CYRKPDLERY EAQAHGRMKP
      1390       1400       1410       1420       1430       1440
LSASQVSVHV GMDDRRRDSP RATPWDQVSY VSQVSLSSLT SDRLSRHGGM AEDGGDKWSL
      1450
LLSDRDEEQC I

Isoforms

- Isoform Short of Copper-transporting ATPase 2 - Isoform PINAM2 of Copper-transporting ATPase 2

Sequence View

        10         20         30         40         50         60
MPEQERKVTA KEASRKILSK LALPTRPWGQ SMKQSFAFDN VGYEGGLDST CFILQLTTGV
        70         80         90        100        110        120
VSILGMTCHS CVKSIEDRIS SLKGIVSIKV SLEQGSATVK YVPSVLNLQQ ICLQIEDMGF
       130        140        150        160        170        180
EASAAEGKAA SWPSRSSPAQ EAVVKLRVEG MTCQSCVSSI EGKIRKLQGV VRVKVSLSNQ
       190        200        210        220        230        240
EAVITYQPYL IQPEDLRDHI CDMGFEAAIK NRTAPLRLGP IDINKLESTN LKRAAVPPIQ
       250        260        270        280        290        300
NSNHLETPGH QQNHLATLPL RIDGMHCKSC VLNIEGNIGQ LPGVQNIHVS LENKTAQVQY
       310        320        330        340        350        360
DSSCITPLFL QTAIEALPPG YFKVSLPDGL EKESGSSSVP SLGSSQRQQE PGPCRTAVLT
       370        380        390        400        410        420
ITGIPRDSSV QPMEDMLSQM KGVQQIDISL AEGTGAVLYD PSVVSSDELR TAVEDMGFEV
       430        440        450        460        470        480
SVNPENITTN RVSSGNSVPQ AVGDSPGSVQ NMASDTRGLL THQGPGYLSD SPPSPGGTAS
       490        500        510        520        530        540
QKCFVQIKGM TCASCVSNIE RSLQRHAGIL SVLVALMSGK AEVKYDPEVI QSPRIAQLIE
       550        560        570        580        590        600
DLGFEAAIME DNTVSEGDIE LIITGMTCAS CVHNIESKLT RTNGITYASV ALATSKAHVK
       610        620        630        640        650        660
FDPEIIGPRD IIKVIEEIGF HASLAHRNPN AHHLDHKTEI KQWKKSFLCS LVFGIPVMGL
       670        680        690        700        710        720
MIYMLIPSSK PHETMVLDHN IIPGLSVLNL IFFILCTFVQ FLGGWYFYVQ AYKSLRHKSA
       730        740        750        760        770        780
NMDVLIVLAT TIAYAYSLVI LVVAIAEKAE KSPVTFFDTP PMLFVFIALG RWLEHVAKSK
       790        800        810        820        830        840
TSEALAKLMS LQATEATVVT LGEDNLILRE EQVPMELVQR GDIIKVVPGG KFPVDGKVLE
       850        860        870        880        890        900
GNTMADESLI TGEAMPVTKK PGSIVIAGSI NAHGSVLIKA THVGNDTTLA QIVKLVEEAQ
       910        920        930        940        950        960
MSKAPIQQLA DRFSGYFVPF IIIISTLTLV VWIIIGFVDF GIVQKYFPSP SKHISQTEVI
       970        980        990       1000       1010       1020
IRFAFQTSIT VLCIACPCSL GLATPTAVMV GTGVAAQNGV LIKGGKPLEM AHKIKTVMFD
      1030       1040       1050       1060       1070       1080
KTGTITHGVP RVMRFLLLVD VATLSLRKVL AVVGTAEASS EHPLGVAVTK YCKEELGTET
      1090       1100       1110       1120       1130       1140
LGYSTDFQAV PGCGISCKVS NVESILAHRG PTAHPIGVGN PPIGEGTGPQ TFSVLIGNRE
      1150       1160       1170       1180       1190       1200
WMRRNGLTIS SDISDAMTDH EMKGQTAILV AIDGVLCGMI AIADAVKPEA ALASITLKSM
      1210       1220       1230       1240       1250       1260
GVDVALITGD NRKTARAIAT QVGINKVFAE VLPSHKVAKV QELQNKGKKV AMVGDGVNDS
      1270       1280       1290       1300       1310       1320
PALAQADVGI AIGTGTDVAI DAADVVLIRN DLLDVVASIH LSKRTVRRIR VNLVLALIYN
      1330       1340       1350       1360       1370       1380
MVGIPIAAGV FMPIGIVLQP WMGSAAASSV SVVLSSLQLK CYRKPDLERY EAQAHGRMKP
      1390       1400       1410       1420       1430       1440
LSASQVSVHV GMDDRRRDSP RATPWDQVSY VSQVSLSSLT SDRLSRHGGM AEDGGDKWSL
      1450
LLSDRDEEQC I         10         20         30         40         50         60
MPEQERKVTA KEASRKILSK LALPTRPWGQ SMKQSFAFDN VGYEGGLDST CFILQLTTGV
        70         80         90        100        110        120
VSILGMTCHS CVKSIEDRIS SLKGIVSIKV SLEQGSATVK YVPSVLNLQQ ICLQIEDMGF
       130        140        150        160        170        180
EASAAEGKAA SWPSRSSPAQ EAVVKLRVEG MTCQSCVSSI EGKIRKLQGV VRVKVSLSNQ
       190        200        210        220        230        240
EAVITYQPYL IQPEDLRDHI CDMGFEAAIK NRTAPLRLGP IDINKLESTN LKRAAVPPIQ
       250        260        270        280        290        300
NSNHLETPGH QQNHLATLPL RIDGMHCKSC VLNIEGNIGQ LPGVQNIHVS LENKTAQVQY
       310        320        330        340        350        360
DSSCITPLFL QTAIEALPPG YFKVSLPDGL EKESGSSSVP SLGSSQRQQE PGPCRTAVLT
       370        380        390        400        410        420
ITGIPRDSSV QPMEDMLSQM KGVQQIDISL AEGTGAVLYD PSVVSSDELR TAVEDMGFEV
       430        440        450        460        470        480
SVNPENITTN RVSSGNSVPQ AVGDSPGSVQ NMASDTRGLL THQGPGYLSD SPPSPGGTAS
       490        500        510        520        530        540
QKCFVQIKGM TCASCVSNIE RSLQRHAGIL SVLVALMSGK AEVKYDPEVI QSPRIAQLIE
       550        560        570        580        590        600
DLGFEAAIME DNTVSEGDIE LIITGMTCAS CVHNIESKLT RTNGITYASV ALATSKAHVK
       610        620        630        640        650        660
FDPEIIGPRD IIKVIEEIGF HASLAHRNPN AHHLDHKTEI KQWKKSFLCS LVFGIPVMGL
       670        680        690        700        710        720
MIYMLIPSSK PHETMVLDHN IIPGLSVLNL IFFILCTFVQ FLGGWYFYVQ AYKSLRHKSA
       730        740        750        760        770        780
NMDVLIVLAT TIAYAYSLVI LVVAIAEKAE KSPVTFFDTP PMLFVFIALG RWLEHVAKSK
       790        800        810        820        830        840
TSEALAKLMS LQATEATVVT LGEDNLILRE EQVPMELVQR GDIIKVVPGG KFPVDGKVLE
       850        860        870        880        890        900
GNTMADESLI TGEAMPVTKK PGSIVIAGSI NAHGSVLIKA THVGNDTTLA QIVKLVEEAQ
       910        920        930        940        950        960
MSKAPIQQLA DRFSGYFVPF IIIISTLTLV VWIIIGFVDF GIVQKYFPSP SKHISQTEVI
       970        980        990       1000       1010       1020
IRFAFQTSIT VLCIACPCSL GLATPTAVMV GTGVAAQNGV LIKGGKPLEM AHKIKTVMFD
      1030       1040       1050       1060       1070       1080
KTGTITHGVP RVMRFLLLVD VATLSLRKVL AVVGTAEASS EHPLGVAVTK YCKEELGTET
      1090       1100       1110       1120       1130       1140
LGYSTDFQAV PGCGISCKVS NVESILAHRG PTAHPIGVGN PPIGEGTGPQ TFSVLIGNRE
      1150       1160       1170       1180       1190       1200
WMRRNGLTIS SDISDAMTDH EMKGQTAILV AIDGVLCGMI AIADAVKPEA ALASITLKSM
      1210       1220       1230       1240       1250       1260
GVDVALITGD NRKTARAIAT QVGINKVFAE VLPSHKVAKV QELQNKGKKV AMVGDGVNDS
      1270       1280       1290       1300       1310       1320
PALAQADVGI AIGTGTDVAI DAADVVLIRN DLLDVVASIH LSKRTVRRIR VNLVLALIYN
      1330       1340       1350       1360       1370       1380
MVGIPIAAGV FMPIGIVLQP WMGSAAASSV SVVLSSLQLK CYRKPDLERY EAQAHGRMKP
      1390       1400       1410       1420       1430       1440
LSASQVSVHV GMDDRRRDSP RATPWDQVSY VSQVSLSSLT SDRLSRHGGM AEDGGDKWSL
      1450
LLSDRDEEQC I

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q64535-1-unknown	MPEQER...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q64535-789-unknown	MSLQAT...	789	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt192317
Q64535-815-unknown	MELVQR...	815	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt192318
Q64535-815-unknown	MELVQR...	815	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt193869

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EEQCI	1451	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...EEQCI	1451	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt152264
...EEQCI	1451	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt152263

TopFIND

Q64535: Copper-transporting ATPase 2

General Information

3

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates