TopFIND 4.0

Q64725: Tyrosine-protein kinase SYK

General Information

Protein names
- Tyrosine-protein kinase SYK
- 2.7.10.2
- Spleen tyrosine kinase
- p72Syk
Gene names Syk
Organism Rattus norvegicus
Protease Family
Protease ID
Chromosome location
UniProt ID Q64725

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MAGNAVDNAN HLTYFFGNIT REEAEDYLVQ GGMTDGLYLL RQSRNYLGGF ALSVAHNRKA 
        70         80         90        100        110        120 
HHYTIERELN GTYAISGGRA HASPADLCHY HSQEPEGLVC LLKKPFNRPP GVQPKTGPFE 
       130        140        150        160        170        180 
DLKENLIREY VKQTWNLQGQ ALEQAIISQK PQLEKLIATT AHEKMPWFHG NISRDESEQT 
       190        200        210        220        230        240 
VLIGSKTNGK FLIRARDNNG SFALCLLHEG KVLHYRIDRD KTGKLSIPEG KKFDTLWQLV 
       250        260        270        280        290        300 
EHYSYKPDGL LRVLTVPCQK IGVQMGHPGS SNAHPVTWSP GGIISRIKSY SFPKPGHKKP 
       310        320        330        340        350        360 
PPPQGSRPES TVSFNPYEPT GGAWGPDRGL QREALPMDTE VYESPYADPE EIRPKEVYLD 
       370        380        390        400        410        420 
RKLLTLEDNE LGSGNFGTVK KGYYQMKKVV KTVAVKILKN EANDPALKDE LLAEANVMQQ 
       430        440        450        460        470        480 
LDNPYIVRMI GICEAESWML VMEMAAWGPL NKYLQQNRHI KDKNIIELVH QVSMGMKYLE 
       490        500        510        520        530        540 
ESNFVHRDLA ARNVLLVTQH YAKISDFGLS KALRADENYY KAQTHGKWPV KWYAPECINY 
       550        560        570        580        590        600 
FKFSSKSDVW SFGVLMWEAF SYGQKPYRGM KGSEVTAMLE KGERMGCPPG CPREMYDLMF 
       610        620    
LCWTYDVENR PGFAAVELRL RNYYYDVVN

Isoforms

- Isoform SykA of Tyrosine-protein kinase SYK

Sequence View

        10         20         30         40         50         60 
MAGNAVDNAN HLTYFFGNIT REEAEDYLVQ GGMTDGLYLL RQSRNYLGGF ALSVAHNRKA 
        70         80         90        100        110        120 
HHYTIERELN GTYAISGGRA HASPADLCHY HSQEPEGLVC LLKKPFNRPP GVQPKTGPFE 
       130        140        150        160        170        180 
DLKENLIREY VKQTWNLQGQ ALEQAIISQK PQLEKLIATT AHEKMPWFHG NISRDESEQT 
       190        200        210        220        230        240 
VLIGSKTNGK FLIRARDNNG SFALCLLHEG KVLHYRIDRD KTGKLSIPEG KKFDTLWQLV 
       250        260        270        280        290        300 
EHYSYKPDGL LRVLTVPCQK IGVQMGHPGS SNAHPVTWSP GGIISRIKSY SFPKPGHKKP 
       310        320        330        340        350        360 
PPPQGSRPES TVSFNPYEPT GGAWGPDRGL QREALPMDTE VYESPYADPE EIRPKEVYLD 
       370        380        390        400        410        420 
RKLLTLEDNE LGSGNFGTVK KGYYQMKKVV KTVAVKILKN EANDPALKDE LLAEANVMQQ 
       430        440        450        460        470        480 
LDNPYIVRMI GICEAESWML VMEMAAWGPL NKYLQQNRHI KDKNIIELVH QVSMGMKYLE 
       490        500        510        520        530        540 
ESNFVHRDLA ARNVLLVTQH YAKISDFGLS KALRADENYY KAQTHGKWPV KWYAPECINY 
       550        560        570        580        590        600 
FKFSSKSDVW SFGVLMWEAF SYGQKPYRGM KGSEVTAMLE KGERMGCPPG CPREMYDLMF 
       610        620    
LCWTYDVENR PGFAAVELRL RNYYYDVVN



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Evidence Codes:


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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q64725-1-unknown MAGNAV... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q64725-1-unknown MAGNAV... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt192899

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...YDVVN 629 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...YDVVN 629 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt152845

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)