TopFIND 4.0

Q68G58: DNA-(apurinic or apyrimidinic site) lyase 2

General Information

Protein names
- DNA-(apurinic or apyrimidinic site) lyase 2
- 3.1.-.-
- 4.2.99.18
- APEX nuclease 2
- Apurinic-apyrimidinic endonuclease 2
- AP endonuclease 2
Gene names Apex2
Organism Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID Q68G58

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MLRVVSWNIN GIRSPLQGLA CQEPSSCPTA LRRVLDELDA DIVCLQETKV TRDVLTEPLA 
        70         80         90        100        110        120 
IVEGYNSYFS FSRSRSGYSG VATFCKDSAT PVAAEEGLSG VFATLNGDIG CYGNMDEFTQ 
       130        140        150        160        170        180 
EELRVLDSEG RALLTQHKIR TLEGKEKTLT LINVYCPHAD PGKPERLTFK MRFYRLLQMR 
       190        200        210        220        230        240 
AEALLAAGSH VIILGDLNTA HRPIDHCDAS SLECFEEDPG RKWMDGLLSN PGDEAGPHIG 
       250        260        270        280        290        300 
LFMDSYRYLH PKQQRAFTCW SVVSGARHLN YGSRLDYVLG DRALVIDTFQ ASFLLPEVMG 
       310        320        330        340        350        360 
SDHCPVGAVL NVSCVPAKQC PALCTRFLPE FAGTQLKILR FLVPLEQEPV REQQVLQPSH 
       370        380        390        400        410        420 
QIQAQRQPRK ACMHSTRLRK SQGGPKRKQK NLMSYFQPSS SLSQTSGVEL PTLPLVGPLT 
       430        440        450        460        470        480 
TPKTAEEVAT ATVLEEKNKV PESKDEKGER TAFWKSMLSG PSPMPLCGGH REPCVMRTVK 
       490        500        510    
KTGPNFGRQF YMCARPRGPP SDPSSRCNFF LWSRPS

Isoforms

- Isoform 2 of DNA-(apurinic or apyrimidinic site) lyase 2 - Isoform 3 of DNA-(apurinic or apyrimidinic site) lyase 2 - Isoform 4 of DNA-(apurinic or apyrimidinic site) lyase 2 - Isoform 5 of DNA-(apurinic or apyrimidinic site) lyase 2

Sequence View

        10         20         30         40         50         60 
MLRVVSWNIN GIRSPLQGLA CQEPSSCPTA LRRVLDELDA DIVCLQETKV TRDVLTEPLA 
        70         80         90        100        110        120 
IVEGYNSYFS FSRSRSGYSG VATFCKDSAT PVAAEEGLSG VFATLNGDIG CYGNMDEFTQ 
       130        140        150        160        170        180 
EELRVLDSEG RALLTQHKIR TLEGKEKTLT LINVYCPHAD PGKPERLTFK MRFYRLLQMR 
       190        200        210        220        230        240 
AEALLAAGSH VIILGDLNTA HRPIDHCDAS SLECFEEDPG RKWMDGLLSN PGDEAGPHIG 
       250        260        270        280        290        300 
LFMDSYRYLH PKQQRAFTCW SVVSGARHLN YGSRLDYVLG DRALVIDTFQ ASFLLPEVMG 
       310        320        330        340        350        360 
SDHCPVGAVL NVSCVPAKQC PALCTRFLPE FAGTQLKILR FLVPLEQEPV REQQVLQPSH 
       370        380        390        400        410        420 
QIQAQRQPRK ACMHSTRLRK SQGGPKRKQK NLMSYFQPSS SLSQTSGVEL PTLPLVGPLT 
       430        440        450        460        470        480 
TPKTAEEVAT ATVLEEKNKV PESKDEKGER TAFWKSMLSG PSPMPLCGGH REPCVMRTVK 
       490        500        510    
KTGPNFGRQF YMCARPRGPP SDPSSRCNFF LWSRPS         10         20         30         40         50         60 
MLRVVSWNIN GIRSPLQGLA CQEPSSCPTA LRRVLDELDA DIVCLQETKV TRDVLTEPLA 
        70         80         90        100        110        120 
IVEGYNSYFS FSRSRSGYSG VATFCKDSAT PVAAEEGLSG VFATLNGDIG CYGNMDEFTQ 
       130        140        150        160        170        180 
EELRVLDSEG RALLTQHKIR TLEGKEKTLT LINVYCPHAD PGKPERLTFK MRFYRLLQMR 
       190        200        210        220        230        240 
AEALLAAGSH VIILGDLNTA HRPIDHCDAS SLECFEEDPG RKWMDGLLSN PGDEAGPHIG 
       250        260        270        280        290        300 
LFMDSYRYLH PKQQRAFTCW SVVSGARHLN YGSRLDYVLG DRALVIDTFQ ASFLLPEVMG 
       310        320        330        340        350        360 
SDHCPVGAVL NVSCVPAKQC PALCTRFLPE FAGTQLKILR FLVPLEQEPV REQQVLQPSH 
       370        380        390        400        410        420 
QIQAQRQPRK ACMHSTRLRK SQGGPKRKQK NLMSYFQPSS SLSQTSGVEL PTLPLVGPLT 
       430        440        450        460        470        480 
TPKTAEEVAT ATVLEEKNKV PESKDEKGER TAFWKSMLSG PSPMPLCGGH REPCVMRTVK 
       490        500        510    
KTGPNFGRQF YMCARPRGPP SDPSSRCNFF LWSRPS         10         20         30         40         50         60 
MLRVVSWNIN GIRSPLQGLA CQEPSSCPTA LRRVLDELDA DIVCLQETKV TRDVLTEPLA 
        70         80         90        100        110        120 
IVEGYNSYFS FSRSRSGYSG VATFCKDSAT PVAAEEGLSG VFATLNGDIG CYGNMDEFTQ 
       130        140        150        160        170        180 
EELRVLDSEG RALLTQHKIR TLEGKEKTLT LINVYCPHAD PGKPERLTFK MRFYRLLQMR 
       190        200        210        220        230        240 
AEALLAAGSH VIILGDLNTA HRPIDHCDAS SLECFEEDPG RKWMDGLLSN PGDEAGPHIG 
       250        260        270        280        290        300 
LFMDSYRYLH PKQQRAFTCW SVVSGARHLN YGSRLDYVLG DRALVIDTFQ ASFLLPEVMG 
       310        320        330        340        350        360 
SDHCPVGAVL NVSCVPAKQC PALCTRFLPE FAGTQLKILR FLVPLEQEPV REQQVLQPSH 
       370        380        390        400        410        420 
QIQAQRQPRK ACMHSTRLRK SQGGPKRKQK NLMSYFQPSS SLSQTSGVEL PTLPLVGPLT 
       430        440        450        460        470        480 
TPKTAEEVAT ATVLEEKNKV PESKDEKGER TAFWKSMLSG PSPMPLCGGH REPCVMRTVK 
       490        500        510    
KTGPNFGRQF YMCARPRGPP SDPSSRCNFF LWSRPS         10         20         30         40         50         60 
MLRVVSWNIN GIRSPLQGLA CQEPSSCPTA LRRVLDELDA DIVCLQETKV TRDVLTEPLA 
        70         80         90        100        110        120 
IVEGYNSYFS FSRSRSGYSG VATFCKDSAT PVAAEEGLSG VFATLNGDIG CYGNMDEFTQ 
       130        140        150        160        170        180 
EELRVLDSEG RALLTQHKIR TLEGKEKTLT LINVYCPHAD PGKPERLTFK MRFYRLLQMR 
       190        200        210        220        230        240 
AEALLAAGSH VIILGDLNTA HRPIDHCDAS SLECFEEDPG RKWMDGLLSN PGDEAGPHIG 
       250        260        270        280        290        300 
LFMDSYRYLH PKQQRAFTCW SVVSGARHLN YGSRLDYVLG DRALVIDTFQ ASFLLPEVMG 
       310        320        330        340        350        360 
SDHCPVGAVL NVSCVPAKQC PALCTRFLPE FAGTQLKILR FLVPLEQEPV REQQVLQPSH 
       370        380        390        400        410        420 
QIQAQRQPRK ACMHSTRLRK SQGGPKRKQK NLMSYFQPSS SLSQTSGVEL PTLPLVGPLT 
       430        440        450        460        470        480 
TPKTAEEVAT ATVLEEKNKV PESKDEKGER TAFWKSMLSG PSPMPLCGGH REPCVMRTVK 
       490        500        510    
KTGPNFGRQF YMCARPRGPP SDPSSRCNFF LWSRPS



Filter Information:


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Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


Database:


Lab:



Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...WSRPS 516 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...WSRPS 516 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt62835

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)