TopFIND 4.0

Q69ZK0: Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

General Information

Protein names
- Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
- P-Rex1
- PtdIns(3,4,5)-dependent Rac exchanger 1
Gene names Prex1
Organism Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID Q69ZK0

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MEAPGSGGGD GGGDPGGDGA HPDARGPVSG PCAAARDSER QLRLRLCVLN EILGTERDYV 
        70         80         90        100        110        120 
GTLRFLQSAF LQRIRQNVAD SVEKGLTEEN VKVLFSNIED ILEVHKDFLA ALEYCLHPEP 
       130        140        150        160        170        180 
QSQHELGNVF LKFKDKFCVY EEYCSNHEKA LRLLVELNKV PAVRAFLLSC MLLGGRKTTD 
       190        200        210        220        230        240 
IPLEGYLLSP IQRICKYPLL LKELAKRTPG KHPDHTAVQS ALQAMKTVCS NINETKRQME 
       250        260        270        280        290        300 
KLEALEQLQS HIEGWEGSNL TDICTELLLQ GNLLKISAGN IQERAFFLFD NLLVYCKRKS 
       310        320        330        340        350        360 
RVTGSKKSTK RTKSINGSLY IFRGRINTEV MEVENVEDGT ADYHSNGYTV TNGWKIHNTA 
       370        380        390        400        410        420 
KNKWFVCMAK TAEEKQKWLD ALIREREQRE SLKLGMERDA YVMIAEKGEK LYHMMMSKKV 
       430        440        450        460        470        480 
NLIKDRRRKL STVPKCFLGN EFVAWLLEIG EISKTEEGVN LGQALLENGI IHHVSDKHQF 
       490        500        510        520        530        540 
KNEQVMYRFR YDDGTYKARS ELEDIMSKGV RLYCRLHSLY APVIKDRDYH LKTYKSVVPG 
       550        560        570        580        590        600 
SKLVDWLLAQ GDCQTREEAV ALGVGLCNNG FMHHVLEKSE FKDESQYFRF HADEEMEGTS 
       610        620        630        640        650        660 
SKNKQLRNDF KLVENILAKR LLIPPQEDDY GFDLEEKNKA VVVKSVQRGS LAEMAGLQAG 
       670        680        690        700        710        720 
RKIYSINEDL VFLRPFSEVE TILNQFFCSR RPLRLLVATK AKETIKVPDH PEALSFQIRG 
       730        740        750        760        770        780 
TAPPCVFAVG RGSEAVAAGL CAGQCILKVN GTSVANDGAL EVLEHFQAFR NHREEALGLY 
       790        800        810        820        830        840 
QWVYHSHEDA QLARASQGAP DEDPQEDDQP DSALPLLSLG PQLSLHEDSA VVSLTLDNVH 
       850        860        870        880        890        900 
LEHGVVYEYM STAGAKCHVL EKIVEPRGCF RLAAKILEAF AVDDSIFVQN CGRLMAMSSA 
       910        920        930        940        950        960 
IVTMSHYEFH NICDTKLESI GQRIACYQEF AAQLKSRVSP PFKQASLEPH PLCGLDFCPT 
       970        980        990       1000       1010       1020 
NCHVNLMEVS YPKTTPSVGR SFSIRFGRKP SLIGLDPEQG LNPMAYTQHC ITTMAAPSWK 
      1030       1040       1050       1060       1070       1080 
CSPAVDEDSQ GQGLNDSSYG SASGAPSQQD RGLSFLLKQE DREIQDAYLQ LFTKLDVALK 
      1090       1100       1110       1120       1130       1140 
EMKQYVTQIN RLLSTITEPT SAAPAPCDPS LVEETSSSPP VSEESEVDRT DHSGIKKVCF 
      1150       1160       1170       1180       1190       1200 
KVSEDEQEDS GHDTMSYRDS YSECNSNRDS VLSYTSVRSN SSYLGSDEMG SGDELPCDMR 
      1210       1220       1230       1240       1250       1260 
IPSDKQDKLH GCLEHLFNQV DSIHALLKGP VMSRAFEETR HFPMKHSWQE FKQKEECTVR 
      1270       1280       1290       1300       1310       1320 
GRNLIQISIQ EDPWNLPSSI RTLVDNIQQY VEDGKNQLLL ALLKCTDTEL QLRRDAVFCQ 
      1330       1340       1350       1360       1370       1380 
ALVAAVCTFS EQLLAALDYR YNNNGEYEES SRDASRKWLE QVAATGVLLH WQSLLAPASV 
      1390       1400       1410       1420       1430       1440 
KEERTMLEDI WVTLSELDNV TFSFKQLDEN SVANTNVFYH IEGSRQALKV VFYLDGFHFS 
      1450       1460       1470       1480       1490       1500 
RLPSRLEGGA SLRLHTVLFT KALESVEGPP PPGNQAAEEL QQEINAQSLE KVQQYYRKLR 
      1510       1520       1530       1540       1550       1560 
AFYLERSNLP TDAGATAVKI DQLIRPINAL DELYRLMKTF VHPKAGAAGS LGAGLIPVSS 
      1570       1580       1590       1600       1610       1620 
ELCYRLGACQ ITMCGTGMQR STLSVSLEQA AILARSHGLL PKCVMQATDI MRKQGPRVEI 
      1630       1640       1650    
LAKNLRIKDP MPQGAPRLYQ LCQPPVDGDL 

Isoforms

- Isoform 2 of Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Sequence View

        10         20         30         40         50         60 
MEAPGSGGGD GGGDPGGDGA HPDARGPVSG PCAAARDSER QLRLRLCVLN EILGTERDYV 
        70         80         90        100        110        120 
GTLRFLQSAF LQRIRQNVAD SVEKGLTEEN VKVLFSNIED ILEVHKDFLA ALEYCLHPEP 
       130        140        150        160        170        180 
QSQHELGNVF LKFKDKFCVY EEYCSNHEKA LRLLVELNKV PAVRAFLLSC MLLGGRKTTD 
       190        200        210        220        230        240 
IPLEGYLLSP IQRICKYPLL LKELAKRTPG KHPDHTAVQS ALQAMKTVCS NINETKRQME 
       250        260        270        280        290        300 
KLEALEQLQS HIEGWEGSNL TDICTELLLQ GNLLKISAGN IQERAFFLFD NLLVYCKRKS 
       310        320        330        340        350        360 
RVTGSKKSTK RTKSINGSLY IFRGRINTEV MEVENVEDGT ADYHSNGYTV TNGWKIHNTA 
       370        380        390        400        410        420 
KNKWFVCMAK TAEEKQKWLD ALIREREQRE SLKLGMERDA YVMIAEKGEK LYHMMMSKKV 
       430        440        450        460        470        480 
NLIKDRRRKL STVPKCFLGN EFVAWLLEIG EISKTEEGVN LGQALLENGI IHHVSDKHQF 
       490        500        510        520        530        540 
KNEQVMYRFR YDDGTYKARS ELEDIMSKGV RLYCRLHSLY APVIKDRDYH LKTYKSVVPG 
       550        560        570        580        590        600 
SKLVDWLLAQ GDCQTREEAV ALGVGLCNNG FMHHVLEKSE FKDESQYFRF HADEEMEGTS 
       610        620        630        640        650        660 
SKNKQLRNDF KLVENILAKR LLIPPQEDDY GFDLEEKNKA VVVKSVQRGS LAEMAGLQAG 
       670        680        690        700        710        720 
RKIYSINEDL VFLRPFSEVE TILNQFFCSR RPLRLLVATK AKETIKVPDH PEALSFQIRG 
       730        740        750        760        770        780 
TAPPCVFAVG RGSEAVAAGL CAGQCILKVN GTSVANDGAL EVLEHFQAFR NHREEALGLY 
       790        800        810        820        830        840 
QWVYHSHEDA QLARASQGAP DEDPQEDDQP DSALPLLSLG PQLSLHEDSA VVSLTLDNVH 
       850        860        870        880        890        900 
LEHGVVYEYM STAGAKCHVL EKIVEPRGCF RLAAKILEAF AVDDSIFVQN CGRLMAMSSA 
       910        920        930        940        950        960 
IVTMSHYEFH NICDTKLESI GQRIACYQEF AAQLKSRVSP PFKQASLEPH PLCGLDFCPT 
       970        980        990       1000       1010       1020 
NCHVNLMEVS YPKTTPSVGR SFSIRFGRKP SLIGLDPEQG LNPMAYTQHC ITTMAAPSWK 
      1030       1040       1050       1060       1070       1080 
CSPAVDEDSQ GQGLNDSSYG SASGAPSQQD RGLSFLLKQE DREIQDAYLQ LFTKLDVALK 
      1090       1100       1110       1120       1130       1140 
EMKQYVTQIN RLLSTITEPT SAAPAPCDPS LVEETSSSPP VSEESEVDRT DHSGIKKVCF 
      1150       1160       1170       1180       1190       1200 
KVSEDEQEDS GHDTMSYRDS YSECNSNRDS VLSYTSVRSN SSYLGSDEMG SGDELPCDMR 
      1210       1220       1230       1240       1250       1260 
IPSDKQDKLH GCLEHLFNQV DSIHALLKGP VMSRAFEETR HFPMKHSWQE FKQKEECTVR 
      1270       1280       1290       1300       1310       1320 
GRNLIQISIQ EDPWNLPSSI RTLVDNIQQY VEDGKNQLLL ALLKCTDTEL QLRRDAVFCQ 
      1330       1340       1350       1360       1370       1380 
ALVAAVCTFS EQLLAALDYR YNNNGEYEES SRDASRKWLE QVAATGVLLH WQSLLAPASV 
      1390       1400       1410       1420       1430       1440 
KEERTMLEDI WVTLSELDNV TFSFKQLDEN SVANTNVFYH IEGSRQALKV VFYLDGFHFS 
      1450       1460       1470       1480       1490       1500 
RLPSRLEGGA SLRLHTVLFT KALESVEGPP PPGNQAAEEL QQEINAQSLE KVQQYYRKLR 
      1510       1520       1530       1540       1550       1560 
AFYLERSNLP TDAGATAVKI DQLIRPINAL DELYRLMKTF VHPKAGAAGS LGAGLIPVSS 
      1570       1580       1590       1600       1610       1620 
ELCYRLGACQ ITMCGTGMQR STLSVSLEQA AILARSHGLL PKCVMQATDI MRKQGPRVEI 
      1630       1640       1650    
LAKNLRIKDP MPQGAPRLYQ LCQPPVDGDL 



Filter Information:


(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


Database:


Lab:



Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q69ZK0-1-unknown MEAPGS... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q69ZK0-1189-unknown MGSGDE... 1189 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt86161

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...VDGDL 1650 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...VDGDL 1650 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt81779

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)