Q69ZT1: Fanconi-associated nuclease 1 {ECO:0000250|UniProtKB:Q9Y2M0}
Protein names | - Fanconi-associated nuclease 1 {ECO:0000250|UniProtKB:Q9Y2M0} - 3.1.21.- {ECO:0000269|PubMed:24981866} - 3.1.4.1 {ECO:0000269|PubMed:24981866} - FANCD2/FANCI-associated nuclease 1 {ECO:0000250|UniProtKB:Q9Y2M0} - mFAN1 {ECO:0000303|PubMed:24981866} - Myotubularin-related protein 15 |
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Gene names | Fan1 |
Organism | Mus musculus |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q69ZT1 |
2
N-termini
2
C-termini
1
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MPSQRKSPDQ KRPRRSLSTS KTAKSQCHSI TSYFNSAPPA KLACSTCHKM VPRYDLIRHL
70 80 90 100 110 120
DESCANNGVG DDVQVEPAQA GLMSPTVPTS DLPSGPLENV TPQKLSPPKR SLISVQCGSK
130 140 150 160 170 180
LGIQQQTSPY FKDALVSKDQ NELPNQSVEI MPLGSLTSKL SRRYLNAKKS LAKNEGLASQ
190 200 210 220 230 240
CPQTSPSTPG TSLTDNCPEM EDKDEVLNSS QKENIYSCAP LKEENASEQK VKNNKITGDE
250 260 270 280 290 300
SQKASCGEPA LTPASAEHAS ILLSSDSTLV SNTKSSPGDT LVKQESARRA DVGLAEPLEV
310 320 330 340 350 360
RSHKEVQMTF DAAAKTLVSG EAESNGPTDV DMSDMTTWSN NQELVREAGS VLHCPLEQGS
370 380 390 400 410 420
SCGGPSETAQ LALSHPYYLR SFLVVLQALL GNEEDMKLFD EQEKAIITRF YQLSASGQKL
430 440 450 460 470 480
YVRLFQRKLT WIKMSKLEYE EIASDLTPVV EELKDSGFLQ TESELQELSD VLELLSAPEL
490 500 510 520 530 540
KALAKTFHLV SPGGQKQQLV DAFHKLAKQR SVCTWGKTQP GIRAVILKRA KDLAGRSLRV
550 560 570 580 590 600
CKGPRAVFAR ILLLFSLTDS MEDEEAACGG QGQLSTVLLV NLGRMEFPQY TICRKTQIFR
610 620 630 640 650 660
DREDLIRYAA AAHMLSDISA AMASGNWEDA KELARSAKRD WEQLKSHPSL RYHEALPPFL
670 680 690 700 710 720
RCFTVGWIYT RISSRAVEVL ERLHMYEEAV KELENLLSQK IYCPDSRGRW WDRLALNLHQ
730 740 750 760 770 780
HLKRLEEAIR CIREGLADPH VRTGHRLSLY QRAVRLRESP SCRKYKHLFS RLPEVAVGDV
790 800 810 820 830 840
KHVTITGRLC PQHGMGKSVF VMESGDGANP TTVLCSVEEL ALGYYRQSGF DQGIHGEGST
850 860 870 880 890 900
FSTLCGLLLW DIIFMDGIPD VFRNAYQASP LDLLTDSFFA SREQALEARL QLIHSAPAES
910 920 930 940 950 960
LRAWVGEAWQ AQQGRVASLV SWDRFTSLQQ AQDLVSCLGG PVLSGVCRRL AADFRHCRGG
970 980 990 1000 1010 1020
LPDLVVWNSQ SHHCKLVEVK GPSDRLSCKQ MIWLYELQKL GADVEVCHVV AVGAKSKGLG
Isoforms
- Isoform 2 of Fanconi-associated nuclease 1 - Isoform 3 of Fanconi-associated nuclease 1 - Isoform 4 of Fanconi-associated nuclease 1Sequence View
10 20 30 40 50 60
MPSQRKSPDQ KRPRRSLSTS KTAKSQCHSI TSYFNSAPPA KLACSTCHKM VPRYDLIRHL
70 80 90 100 110 120
DESCANNGVG DDVQVEPAQA GLMSPTVPTS DLPSGPLENV TPQKLSPPKR SLISVQCGSK
130 140 150 160 170 180
LGIQQQTSPY FKDALVSKDQ NELPNQSVEI MPLGSLTSKL SRRYLNAKKS LAKNEGLASQ
190 200 210 220 230 240
CPQTSPSTPG TSLTDNCPEM EDKDEVLNSS QKENIYSCAP LKEENASEQK VKNNKITGDE
250 260 270 280 290 300
SQKASCGEPA LTPASAEHAS ILLSSDSTLV SNTKSSPGDT LVKQESARRA DVGLAEPLEV
310 320 330 340 350 360
RSHKEVQMTF DAAAKTLVSG EAESNGPTDV DMSDMTTWSN NQELVREAGS VLHCPLEQGS
370 380 390 400 410 420
SCGGPSETAQ LALSHPYYLR SFLVVLQALL GNEEDMKLFD EQEKAIITRF YQLSASGQKL
430 440 450 460 470 480
YVRLFQRKLT WIKMSKLEYE EIASDLTPVV EELKDSGFLQ TESELQELSD VLELLSAPEL
490 500 510 520 530 540
KALAKTFHLV SPGGQKQQLV DAFHKLAKQR SVCTWGKTQP GIRAVILKRA KDLAGRSLRV
550 560 570 580 590 600
CKGPRAVFAR ILLLFSLTDS MEDEEAACGG QGQLSTVLLV NLGRMEFPQY TICRKTQIFR
610 620 630 640 650 660
DREDLIRYAA AAHMLSDISA AMASGNWEDA KELARSAKRD WEQLKSHPSL RYHEALPPFL
670 680 690 700 710 720
RCFTVGWIYT RISSRAVEVL ERLHMYEEAV KELENLLSQK IYCPDSRGRW WDRLALNLHQ
730 740 750 760 770 780
HLKRLEEAIR CIREGLADPH VRTGHRLSLY QRAVRLRESP SCRKYKHLFS RLPEVAVGDV
790 800 810 820 830 840
KHVTITGRLC PQHGMGKSVF VMESGDGANP TTVLCSVEEL ALGYYRQSGF DQGIHGEGST
850 860 870 880 890 900
FSTLCGLLLW DIIFMDGIPD VFRNAYQASP LDLLTDSFFA SREQALEARL QLIHSAPAES
910 920 930 940 950 960
LRAWVGEAWQ AQQGRVASLV SWDRFTSLQQ AQDLVSCLGG PVLSGVCRRL AADFRHCRGG
970 980 990 1000 1010 1020
LPDLVVWNSQ SHHCKLVEVK GPSDRLSCKQ MIWLYELQKL GADVEVCHVV AVGAKSKGLG
10 20 30 40 50 60
MPSQRKSPDQ KRPRRSLSTS KTAKSQCHSI TSYFNSAPPA KLACSTCHKM VPRYDLIRHL
70 80 90 100 110 120
DESCANNGVG DDVQVEPAQA GLMSPTVPTS DLPSGPLENV TPQKLSPPKR SLISVQCGSK
130 140 150 160 170 180
LGIQQQTSPY FKDALVSKDQ NELPNQSVEI MPLGSLTSKL SRRYLNAKKS LAKNEGLASQ
190 200 210 220 230 240
CPQTSPSTPG TSLTDNCPEM EDKDEVLNSS QKENIYSCAP LKEENASEQK VKNNKITGDE
250 260 270 280 290 300
SQKASCGEPA LTPASAEHAS ILLSSDSTLV SNTKSSPGDT LVKQESARRA DVGLAEPLEV
310 320 330 340 350 360
RSHKEVQMTF DAAAKTLVSG EAESNGPTDV DMSDMTTWSN NQELVREAGS VLHCPLEQGS
370 380 390 400 410 420
SCGGPSETAQ LALSHPYYLR SFLVVLQALL GNEEDMKLFD EQEKAIITRF YQLSASGQKL
430 440 450 460 470 480
YVRLFQRKLT WIKMSKLEYE EIASDLTPVV EELKDSGFLQ TESELQELSD VLELLSAPEL
490 500 510 520 530 540
KALAKTFHLV SPGGQKQQLV DAFHKLAKQR SVCTWGKTQP GIRAVILKRA KDLAGRSLRV
550 560 570 580 590 600
CKGPRAVFAR ILLLFSLTDS MEDEEAACGG QGQLSTVLLV NLGRMEFPQY TICRKTQIFR
610 620 630 640 650 660
DREDLIRYAA AAHMLSDISA AMASGNWEDA KELARSAKRD WEQLKSHPSL RYHEALPPFL
670 680 690 700 710 720
RCFTVGWIYT RISSRAVEVL ERLHMYEEAV KELENLLSQK IYCPDSRGRW WDRLALNLHQ
730 740 750 760 770 780
HLKRLEEAIR CIREGLADPH VRTGHRLSLY QRAVRLRESP SCRKYKHLFS RLPEVAVGDV
790 800 810 820 830 840
KHVTITGRLC PQHGMGKSVF VMESGDGANP TTVLCSVEEL ALGYYRQSGF DQGIHGEGST
850 860 870 880 890 900
FSTLCGLLLW DIIFMDGIPD VFRNAYQASP LDLLTDSFFA SREQALEARL QLIHSAPAES
910 920 930 940 950 960
LRAWVGEAWQ AQQGRVASLV SWDRFTSLQQ AQDLVSCLGG PVLSGVCRRL AADFRHCRGG
970 980 990 1000 1010 1020
LPDLVVWNSQ SHHCKLVEVK GPSDRLSCKQ MIWLYELQKL GADVEVCHVV AVGAKSKGLG
10 20 30 40 50 60
MPSQRKSPDQ KRPRRSLSTS KTAKSQCHSI TSYFNSAPPA KLACSTCHKM VPRYDLIRHL
70 80 90 100 110 120
DESCANNGVG DDVQVEPAQA GLMSPTVPTS DLPSGPLENV TPQKLSPPKR SLISVQCGSK
130 140 150 160 170 180
LGIQQQTSPY FKDALVSKDQ NELPNQSVEI MPLGSLTSKL SRRYLNAKKS LAKNEGLASQ
190 200 210 220 230 240
CPQTSPSTPG TSLTDNCPEM EDKDEVLNSS QKENIYSCAP LKEENASEQK VKNNKITGDE
250 260 270 280 290 300
SQKASCGEPA LTPASAEHAS ILLSSDSTLV SNTKSSPGDT LVKQESARRA DVGLAEPLEV
310 320 330 340 350 360
RSHKEVQMTF DAAAKTLVSG EAESNGPTDV DMSDMTTWSN NQELVREAGS VLHCPLEQGS
370 380 390 400 410 420
SCGGPSETAQ LALSHPYYLR SFLVVLQALL GNEEDMKLFD EQEKAIITRF YQLSASGQKL
430 440 450 460 470 480
YVRLFQRKLT WIKMSKLEYE EIASDLTPVV EELKDSGFLQ TESELQELSD VLELLSAPEL
490 500 510 520 530 540
KALAKTFHLV SPGGQKQQLV DAFHKLAKQR SVCTWGKTQP GIRAVILKRA KDLAGRSLRV
550 560 570 580 590 600
CKGPRAVFAR ILLLFSLTDS MEDEEAACGG QGQLSTVLLV NLGRMEFPQY TICRKTQIFR
610 620 630 640 650 660
DREDLIRYAA AAHMLSDISA AMASGNWEDA KELARSAKRD WEQLKSHPSL RYHEALPPFL
670 680 690 700 710 720
RCFTVGWIYT RISSRAVEVL ERLHMYEEAV KELENLLSQK IYCPDSRGRW WDRLALNLHQ
730 740 750 760 770 780
HLKRLEEAIR CIREGLADPH VRTGHRLSLY QRAVRLRESP SCRKYKHLFS RLPEVAVGDV
790 800 810 820 830 840
KHVTITGRLC PQHGMGKSVF VMESGDGANP TTVLCSVEEL ALGYYRQSGF DQGIHGEGST
850 860 870 880 890 900
FSTLCGLLLW DIIFMDGIPD VFRNAYQASP LDLLTDSFFA SREQALEARL QLIHSAPAES
910 920 930 940 950 960
LRAWVGEAWQ AQQGRVASLV SWDRFTSLQQ AQDLVSCLGG PVLSGVCRRL AADFRHCRGG
970 980 990 1000 1010 1020
LPDLVVWNSQ SHHCKLVEVK GPSDRLSCKQ MIWLYELQKL GADVEVCHVV AVGAKSKGLG
Protein Neighborhood
Domains & Features
2 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q69ZT1-1-unknown | MPSQRK... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q69ZT1-1-unknown | MPSQRK... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt74768 | |||
Q69ZT1-1-unknown | MPSQRK... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt74769 | |||
Q69ZT1-1-unknown | MPSQRK... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt74770 | |||
Q69ZT1-747-unknown | LSLYQR... | 747 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC30592 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...RTGHRL | 746 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC30592 | |||
...SKGLG | 1020 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
CATE_MOUSE | 746 | GHRL.|.LSLY | inferred from experiment | unknown | MEROPS | Merops CATE_MOUSE -> FAN1_MOUSE @746 |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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