TopFIND 4.0

Q6IE75: Beta-secretase 2

General Information

Protein names
- Beta-secretase 2
- 3.4.23.45 {ECO:0000250|UniProtKB:Q9Y5Z0}
- Beta-site amyloid precursor protein cleaving enzyme 2
- Beta-site APP cleaving enzyme 2
- Memapsin-1
- Membrane-associated aspartic protease 1
- Theta-secretase
Gene names Bace2
Organism Rattus norvegicus
Protease Family
Protease ID A01.041
Chromosome location
UniProt ID Q6IE75

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MGALLRALLL PLLAQWLLRA VPVLAPAPFT LPLQVAGAAN HRASTVPGLG TPELPRADGL 
        70         80         90        100        110        120 
ALALEPARAT ANFLAMVDNL QGDSGRGYYL EMLIGTPPQK VRILVDTGSS NFAVAGAPHS 
       130        140        150        160        170        180 
YIDTYFDSES SSTYHSKGFE VTVKYTQGSW TGFVGEDLVT IPKGFNSSFL VNIATIFESE 
       190        200        210        220        230        240 
NFFLPGIKWN GILGLAYAAL AKPSSSLETF FDSLVAQAKI PDIFSMQMCG AGLPVAGSGT 
       250        260        270        280        290        300 
NGGSLVLGGI EPSLYKGDIW YTPIKEEWYY QIEILKLEIG GQSLNLDCRE YNADKAIVDS 
       310        320        330        340        350        360 
GTTLLRLPQK VFDAVVEAVA RTSLIPEFSD GFWTGAQLAC WTNSETPWAY FPKISIYLRD 
       370        380        390        400        410        420 
ENASRSFRIT ILPQLYIQPM MGAGFNYECY RFGISSSTNA LVIGATVMEG FYVVFDRAQR 
       430        440        450        460        470        480 
RVGFAVSPCA EIAGTTVSEI SGPFSTEDIA SNCVPAQALN EPILWIVSYA LMSVCGAILL 
       490        500        510    
VLILLLLFPL HCRHAPRDPE VVNDESSLVR HRWK

Isoforms



Sequence View



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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q6IE75-63-unknown ALEPAR... 63 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...RHRWK 514 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)