TopFIND 4.0

Q6L8Q7: 2',5'-phosphodiesterase 12

General Information

Protein names
- 2',5'-phosphodiesterase 12
- 2'-PDE
- 2-PDE
- 3.1.4.- {ECO:0000269|PubMed:26055709}
- Mitochondrial deadenylase
- 3.1.13.4 {ECO:0000269|PubMed:21666256, ECO:0000269|PubMed:26055709, ECO:0000269|PubMed:30389976}
Gene names PDE12
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q6L8Q7

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MWRLPGARAA LRVIRTAVEK LSRAEAGSQT AAGAMERAVV RCVPSEPKLS LSFALADGSH 
        70         80         90        100        110        120 
KNMQRDQSEP LGRVLSRIAT NALKGHAKAA AAKKSRKSRP NASGGAACSG PGPEPAVFCE 
       130        140        150        160        170        180 
PVVKLYYREE AVAEDVLNVD AWQDGAVLQI GDVKYKVERN PPAFTELQLP RYIMAGFPVC 
       190        200        210        220        230        240 
PKLSLEFGDP ASSLFRWYKE AKPGAAEPEV GVPSSLSPSS PSSSWTETDV EERVYTPSNA 
       250        260        270        280        290        300 
DIGLRLKLHC TPGDGQRFGH SRELESVCVV EAGPGTCTFD HRHLYTKKVT EDALIRTVSY 
       310        320        330        340        350        360 
NILADTYAQT EFSRTVLYPY CAPYALELDY RQNLIQKELT GYNADVICLQ EVDRAVFSDS 
       370        380        390        400        410        420 
LVPALEAFGL EGVFRIKQHE GLATFYRKSK FSLLSQHDIS FYEALESDPL HKELLEKLVL 
       430        440        450        460        470        480 
YPSAQEKVLQ RSSVLQVSVL QSTKDSSKRI CVANTHLYWH PKGGYIRLIQ MAVALAHIRH 
       490        500        510        520        530        540 
VSCDLYPGIP VIFCGDFNST PSTGMYHFVI NGSIPEDHED WASNGEEERC NMSLTHFFKL 
       550        560        570        580        590        600 
KSACGEPAYT NYVGGFHGCL DYIFIDLNAL EVEQVIPLPS HEEVTTHQAL PSVSHPSDHI 
   
ALVCDLKWK

Isoforms

- Isoform 2 of 2',5'-phosphodiesterase 12

Sequence View

        10         20         30         40         50         60 
MWRLPGARAA LRVIRTAVEK LSRAEAGSQT AAGAMERAVV RCVPSEPKLS LSFALADGSH 
        70         80         90        100        110        120 
KNMQRDQSEP LGRVLSRIAT NALKGHAKAA AAKKSRKSRP NASGGAACSG PGPEPAVFCE 
       130        140        150        160        170        180 
PVVKLYYREE AVAEDVLNVD AWQDGAVLQI GDVKYKVERN PPAFTELQLP RYIMAGFPVC 
       190        200        210        220        230        240 
PKLSLEFGDP ASSLFRWYKE AKPGAAEPEV GVPSSLSPSS PSSSWTETDV EERVYTPSNA 
       250        260        270        280        290        300 
DIGLRLKLHC TPGDGQRFGH SRELESVCVV EAGPGTCTFD HRHLYTKKVT EDALIRTVSY 
       310        320        330        340        350        360 
NILADTYAQT EFSRTVLYPY CAPYALELDY RQNLIQKELT GYNADVICLQ EVDRAVFSDS 
       370        380        390        400        410        420 
LVPALEAFGL EGVFRIKQHE GLATFYRKSK FSLLSQHDIS FYEALESDPL HKELLEKLVL 
       430        440        450        460        470        480 
YPSAQEKVLQ RSSVLQVSVL QSTKDSSKRI CVANTHLYWH PKGGYIRLIQ MAVALAHIRH 
       490        500        510        520        530        540 
VSCDLYPGIP VIFCGDFNST PSTGMYHFVI NGSIPEDHED WASNGEEERC NMSLTHFFKL 
       550        560        570        580        590        600 
KSACGEPAYT NYVGGFHGCL DYIFIDLNAL EVEQVIPLPS HEEVTTHQAL PSVSHPSDHI 
   
ALVCDLKWK



Filter Information:


(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


Database:


Lab:



Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q6L8Q7-1-unknown MWRLPG... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt84654
    Q6L8Q7-17-unknown AVEKLS... 17 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q6L8Q7-17-unknown AVEKLS... 17 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt111849

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...DLKWK 609 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)