TopFIND 4.0

Q6NUM9: All-trans-retinol 13,14-reductase

General Information

Protein names
- All-trans-retinol 13,14-reductase
- 1.3.99.23 {ECO:0000250|UniProtKB:Q64FW2}
- All-trans-13,14-dihydroretinol saturase
- RetSat
- PPAR-alpha-regulated and starvation-induced gene protein
Gene names RETSAT
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q6NUM9

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MWLPLVLLLA VLLLAVLCKV YLGLFSGSSP NPFSEDVKRP PAPLVTDKEA RKKVLKQAFS 
        70         80         90        100        110        120 
ANQVPEKLDV VVIGSGFGGL AAAAILAKAG KRVLVLEQHT KAGGCCHTFG KNGLEFDTGI 
       130        140        150        160        170        180 
HYIGRMEEGS IGRFILDQIT EGQLDWAPLS SPFDIMVLEG PNGRKEYPMY SGEKAYIQGL 
       190        200        210        220        230        240 
KEKFPQEEAI IDKYIKLVKV VSSGAPHAIL LKFLPLPVVQ LLDRCGLLTR FSPFLQASTQ 
       250        260        270        280        290        300 
SLAEVLQQLG ASSELQAVLS YIFPTYGVTP NHSAFSMHAL LVNHYMKGGF YPRGGSSEIA 
       310        320        330        340        350        360 
FHTIPVIQRA GGAVLTKATV QSVLLDSAGK ACGVSVKKGH ELVNIYCPIV VSNAGLFNTY 
       370        380        390        400        410        420 
EHLLPGNARC LPGVKQQLGT VRPGLGMTSV FICLRGTKED LHLPSTNYYV YYDTDMDQAM 
       430        440        450        460        470        480 
ERYVSMPREE AAEHIPLLFF AFPSAKDPTW EDRFPGRSTM IMLIPTAYEW FEEWQAELKG 
       490        500        510        520        530        540 
KRGSDYETFK NSFVEASMSV VLKLFPQLEG KVESVTAGSP LTNQFYLAAP RGACYGADHD 
       550        560        570        580        590        600 
LGRLHPCVMA SLRAQSPIPN LYLTGQDIFT CGLVGALQGA LLCSSAILKR NLYSDLKNLD 
       610    
SRIRAQKKKN 

Isoforms

- Isoform 2 of All-trans-retinol 13,14-reductase

Sequence View

        10         20         30         40         50         60 
MWLPLVLLLA VLLLAVLCKV YLGLFSGSSP NPFSEDVKRP PAPLVTDKEA RKKVLKQAFS 
        70         80         90        100        110        120 
ANQVPEKLDV VVIGSGFGGL AAAAILAKAG KRVLVLEQHT KAGGCCHTFG KNGLEFDTGI 
       130        140        150        160        170        180 
HYIGRMEEGS IGRFILDQIT EGQLDWAPLS SPFDIMVLEG PNGRKEYPMY SGEKAYIQGL 
       190        200        210        220        230        240 
KEKFPQEEAI IDKYIKLVKV VSSGAPHAIL LKFLPLPVVQ LLDRCGLLTR FSPFLQASTQ 
       250        260        270        280        290        300 
SLAEVLQQLG ASSELQAVLS YIFPTYGVTP NHSAFSMHAL LVNHYMKGGF YPRGGSSEIA 
       310        320        330        340        350        360 
FHTIPVIQRA GGAVLTKATV QSVLLDSAGK ACGVSVKKGH ELVNIYCPIV VSNAGLFNTY 
       370        380        390        400        410        420 
EHLLPGNARC LPGVKQQLGT VRPGLGMTSV FICLRGTKED LHLPSTNYYV YYDTDMDQAM 
       430        440        450        460        470        480 
ERYVSMPREE AAEHIPLLFF AFPSAKDPTW EDRFPGRSTM IMLIPTAYEW FEEWQAELKG 
       490        500        510        520        530        540 
KRGSDYETFK NSFVEASMSV VLKLFPQLEG KVESVTAGSP LTNQFYLAAP RGACYGADHD 
       550        560        570        580        590        600 
LGRLHPCVMA SLRAQSPIPN LYLTGQDIFT CGLVGALQGA LLCSSAILKR NLYSDLKNLD 
       610    
SRIRAQKKKN 



Filter Information:


(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q6NUM9-1-unknown MWLPLV... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt87309
    Q6NUM9-19-unknown KVYLGL... 19 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q6NUM9-19-unknown KVYLGL... 19 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt112116

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...QKKKN 610 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)