Q6PHW0: Iodotyrosine deiodinase 1 {ECO:0000303|PubMed:25395621}

General Information

Protein names	- Iodotyrosine deiodinase 1 {ECO:0000303\|PubMed:25395621} - IYD-1 {ECO:0000303\|PubMed:25395621} - 1.21.1.1 {ECO:0000269\|PubMed:15289438, ECO:0000269\|PubMed:18434651, ECO:0000269\|PubMed:25395621} - Iodotyrosine dehalogenase 1 {ECO:0000303\|PubMed:15289438, ECO:0000303\|Ref.2}
Gene names	IYD
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q6PHW0

2 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 3 of Iodotyrosine dehalogenase 1 - Isoform 4 of Iodotyrosine dehalogenase 1 - Isoform 5 of Iodotyrosine dehalogenase 1 - Isoform 6 of Iodotyrosine dehalogenase 1 - Isoform 7 of Iodotyrosine dehalogenase 1 - Isoform 3 of Iodotyrosine deiodinase 1 - Isoform 4 of Iodotyrosine deiodinase 1 - Isoform 5 of Iodotyrosine deiodinase 1 - Isoform 6 of Iodotyrosine deiodinase 1 - Isoform 7 of Iodotyrosine deiodinase 1

Sequence View

        10         20         30         40         50         60
MYFLTPILVA ILCILVVWIF KNADRSMEKK KGEPRTRAEA RPWVDEDLKD SSDLHQAEED
        70         80         90        100        110        120
ADEWQESEEN VEHIPFSHNH YPEKEMVKRS QEFYELLNKR RSVRFISNEQ VPMEVIDNVI
       130        140        150        160        170        180
RTAGTAPSGA HTEPWTFVVV KDPDVKHKIR KIIEEEEEIN YMKRMGHRWV TDLKKLRTNW
       190        200        210        220        230        240
IKEYLDTAPI LILIFKQVHG FAANGKKKVH YYNEISVSIA CGILLAALQN AGLVTVTTTP
       250        260        270        280
LNCGPRLRVL LGRPAHEKLL MLLPVGYPSK EATVPDLKRK PLDQIMVTV         10         20         30         40         50         60
MYFLTPILVA ILCILVVWIF KNADRSMEKK KGEPRTRAEA RPWVDEDLKD SSDLHQAEED
        70         80         90        100        110        120
ADEWQESEEN VEHIPFSHNH YPEKEMVKRS QEFYELLNKR RSVRFISNEQ VPMEVIDNVI
       130        140        150        160        170        180
RTAGTAPSGA HTEPWTFVVV KDPDVKHKIR KIIEEEEEIN YMKRMGHRWV TDLKKLRTNW
       190        200        210        220        230        240
IKEYLDTAPI LILIFKQVHG FAANGKKKVH YYNEISVSIA CGILLAALQN AGLVTVTTTP
       250        260        270        280
LNCGPRLRVL LGRPAHEKLL MLLPVGYPSK EATVPDLKRK PLDQIMVTV         10         20         30         40         50         60
MYFLTPILVA ILCILVVWIF KNADRSMEKK KGEPRTRAEA RPWVDEDLKD SSDLHQAEED
        70         80         90        100        110        120
ADEWQESEEN VEHIPFSHNH YPEKEMVKRS QEFYELLNKR RSVRFISNEQ VPMEVIDNVI
       130        140        150        160        170        180
RTAGTAPSGA HTEPWTFVVV KDPDVKHKIR KIIEEEEEIN YMKRMGHRWV TDLKKLRTNW
       190        200        210        220        230        240
IKEYLDTAPI LILIFKQVHG FAANGKKKVH YYNEISVSIA CGILLAALQN AGLVTVTTTP
       250        260        270        280
LNCGPRLRVL LGRPAHEKLL MLLPVGYPSK EATVPDLKRK PLDQIMVTV         10         20         30         40         50         60
MYFLTPILVA ILCILVVWIF KNADRSMEKK KGEPRTRAEA RPWVDEDLKD SSDLHQAEED
        70         80         90        100        110        120
ADEWQESEEN VEHIPFSHNH YPEKEMVKRS QEFYELLNKR RSVRFISNEQ VPMEVIDNVI
       130        140        150        160        170        180
RTAGTAPSGA HTEPWTFVVV KDPDVKHKIR KIIEEEEEIN YMKRMGHRWV TDLKKLRTNW
       190        200        210        220        230        240
IKEYLDTAPI LILIFKQVHG FAANGKKKVH YYNEISVSIA CGILLAALQN AGLVTVTTTP
       250        260        270        280
LNCGPRLRVL LGRPAHEKLL MLLPVGYPSK EATVPDLKRK PLDQIMVTV         10         20         30         40         50         60
MYFLTPILVA ILCILVVWIF KNADRSMEKK KGEPRTRAEA RPWVDEDLKD SSDLHQAEED
        70         80         90        100        110        120
ADEWQESEEN VEHIPFSHNH YPEKEMVKRS QEFYELLNKR RSVRFISNEQ VPMEVIDNVI
       130        140        150        160        170        180
RTAGTAPSGA HTEPWTFVVV KDPDVKHKIR KIIEEEEEIN YMKRMGHRWV TDLKKLRTNW
       190        200        210        220        230        240
IKEYLDTAPI LILIFKQVHG FAANGKKKVH YYNEISVSIA CGILLAALQN AGLVTVTTTP
       250        260        270        280
LNCGPRLRVL LGRPAHEKLL MLLPVGYPSK EATVPDLKRK PLDQIMVTV         10         20         30         40         50         60
MYFLTPILVA ILCILVVWIF KNADRSMEKK KGEPRTRAEA RPWVDEDLKD SSDLHQAEED
        70         80         90        100        110        120
ADEWQESEEN VEHIPFSHNH YPEKEMVKRS QEFYELLNKR RSVRFISNEQ VPMEVIDNVI
       130        140        150        160        170        180
RTAGTAPSGA HTEPWTFVVV KDPDVKHKIR KIIEEEEEIN YMKRMGHRWV TDLKKLRTNW
       190        200        210        220        230        240
IKEYLDTAPI LILIFKQVHG FAANGKKKVH YYNEISVSIA CGILLAALQN AGLVTVTTTP
       250        260        270        280
LNCGPRLRVL LGRPAHEKLL MLLPVGYPSK EATVPDLKRK PLDQIMVTV         10         20         30         40         50         60
MYFLTPILVA ILCILVVWIF KNADRSMEKK KGEPRTRAEA RPWVDEDLKD SSDLHQAEED
        70         80         90        100        110        120
ADEWQESEEN VEHIPFSHNH YPEKEMVKRS QEFYELLNKR RSVRFISNEQ VPMEVIDNVI
       130        140        150        160        170        180
RTAGTAPSGA HTEPWTFVVV KDPDVKHKIR KIIEEEEEIN YMKRMGHRWV TDLKKLRTNW
       190        200        210        220        230        240
IKEYLDTAPI LILIFKQVHG FAANGKKKVH YYNEISVSIA CGILLAALQN AGLVTVTTTP
       250        260        270        280
LNCGPRLRVL LGRPAHEKLL MLLPVGYPSK EATVPDLKRK PLDQIMVTV         10         20         30         40         50         60
MYFLTPILVA ILCILVVWIF KNADRSMEKK KGEPRTRAEA RPWVDEDLKD SSDLHQAEED
        70         80         90        100        110        120
ADEWQESEEN VEHIPFSHNH YPEKEMVKRS QEFYELLNKR RSVRFISNEQ VPMEVIDNVI
       130        140        150        160        170        180
RTAGTAPSGA HTEPWTFVVV KDPDVKHKIR KIIEEEEEIN YMKRMGHRWV TDLKKLRTNW
       190        200        210        220        230        240
IKEYLDTAPI LILIFKQVHG FAANGKKKVH YYNEISVSIA CGILLAALQN AGLVTVTTTP
       250        260        270        280
LNCGPRLRVL LGRPAHEKLL MLLPVGYPSK EATVPDLKRK PLDQIMVTV         10         20         30         40         50         60
MYFLTPILVA ILCILVVWIF KNADRSMEKK KGEPRTRAEA RPWVDEDLKD SSDLHQAEED
        70         80         90        100        110        120
ADEWQESEEN VEHIPFSHNH YPEKEMVKRS QEFYELLNKR RSVRFISNEQ VPMEVIDNVI
       130        140        150        160        170        180
RTAGTAPSGA HTEPWTFVVV KDPDVKHKIR KIIEEEEEIN YMKRMGHRWV TDLKKLRTNW
       190        200        210        220        230        240
IKEYLDTAPI LILIFKQVHG FAANGKKKVH YYNEISVSIA CGILLAALQN AGLVTVTTTP
       250        260        270        280
LNCGPRLRVL LGRPAHEKLL MLLPVGYPSK EATVPDLKRK PLDQIMVTV         10         20         30         40         50         60
MYFLTPILVA ILCILVVWIF KNADRSMEKK KGEPRTRAEA RPWVDEDLKD SSDLHQAEED
        70         80         90        100        110        120
ADEWQESEEN VEHIPFSHNH YPEKEMVKRS QEFYELLNKR RSVRFISNEQ VPMEVIDNVI
       130        140        150        160        170        180
RTAGTAPSGA HTEPWTFVVV KDPDVKHKIR KIIEEEEEIN YMKRMGHRWV TDLKKLRTNW
       190        200        210        220        230        240
IKEYLDTAPI LILIFKQVHG FAANGKKKVH YYNEISVSIA CGILLAALQN AGLVTVTTTP
       250        260        270        280
LNCGPRLRVL LGRPAHEKLL MLLPVGYPSK EATVPDLKRK PLDQIMVTV

Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q6PHW0-1-unknown	MYFLTP...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt78252
Q6PHW0-1-unknown	MYFLTP...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt78253
Q6PHW0-1-unknown	MYFLTP...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt78254
Q6PHW0-1-unknown	MYFLTP...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt78255
Q6PHW0-24-unknown	DRSMEK...	24	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q6PHW0-24-unknown	DRSMEK...	24	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113598
Q6PHW0-24-unknown	DRSMEK...	24	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113599
Q6PHW0-24-unknown	DRSMEK...	24	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113600
Q6PHW0-24-unknown	DRSMEK...	24	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113601

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...IMVTV	289	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

TopFIND

Q6PHW0: Iodotyrosine deiodinase 1 {ECO:0000303|PubMed:25395621}

General Information

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates