Q6PR54: Telomere-associated protein RIF1 {ECO:0000305}
| Protein names | - Telomere-associated protein RIF1 {ECO:0000305} - Rap1-interacting factor 1 homolog {ECO:0000305|PubMed:15042697} - mRif1 {ECO:0000303|PubMed:15042697} |
|---|---|
| Gene names | Rif1 |
| Organism | Mus musculus |
| Protease Family | |
| Protease ID | |
| Chromosome location | |
| UniProt ID | Q6PR54 |
1
N-termini
1
C-termini
0
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MTAPGRSPLE PLLETWEDPS VPPGEQTDAY LTLTSRMTGE EGKEVIAEIE KNLSRLYTVL
70 80 90 100 110 120
KAHISSQNSE LSSAALQALG FCLYNPRITS GLSEANIQEL LLTLNGIIKS SDKNVCTRAL
130 140 150 160 170 180
WVISKQTFPA ELVSKMVSSI IDSLEVILSK GEIHSAVVDF EALNVIIRLI EQAPVQMGEE
190 200 210 220 230 240
SVRWAKLVIP LVVHSAQKVH LRGATALEMG MPLLLQKQQE IALITEHLMT TKLISELQKL
250 260 270 280 290 300
FKNKNETYVL KLWPLFVKLL GKTLHRSGSF INSLLQLEEL GFRSGTPMIK KIAFIAWKSL
310 320 330 340 350 360
IDNFALNPDI LCSAKRLKLL MQPLSSIHVR TETLALTKLE VWWYLLMRLG PQLPANFEQV
370 380 390 400 410 420
CVPLIQSTIS VDSIPSPQGN SSRGSASPGL SPLTPGHKGA SPYGSPRGNL SSNTGGMAAI
430 440 450 460 470 480
PSIQLLGLEM MLHFLLGPEV LSFAKQHKIV LSLEPLEHPL ISSPSFFSKY AHTLITAVHD
490 500 510 520 530 540
SFVSVGKDAS DAVVSAIWKE LISLVKSVTE AGNRKEKSGS EVLTLLLKSL ENIVKSEVFP
550 560 570 580 590 600
VSKTLVLMEI TVKGLPPKVL GSPAYQVANM DILNGTPALF LIQLIFNNNL LECGVEDEKF
610 620 630 640 650 660
FLNLETLVGC VLSGPTSPLA FSDSVLTVIN QNAKQLVNKE HLWRMWSMIV SPLTDVIHQT
670 680 690 700 710 720
NEVNQGDALE HNFSAIYGAL TLPINHIFSA QTFPTGTMKA LLKTWSELYR AFTRCASLVA
730 740 750 760 770 780
TAEENLCCEE LSSKIMCSLE DEVLSDLLFL DRISHIIIVM VDCIDFSPYN KKYQPKIKSP
790 800 810 820 830 840
QRSSDWSRKK KEPLGKLASL FKLIVKVIDT FHTLSLKETF SDTLLAIGNS IISMLSNVFG
850 860 870 880 890 900
HISLPSMIRE IFATFTRPLA LLYENSKLDE APKVYTSLNN KLEKLLGEIV ACLQFSYLGA
910 920 930 940 950 960
YDSELLEHLS PLLCVIFLHK NKQIRKQSAL LWNATFAKAT ALVYPEELKP ILRQAKQKIL
970 980 990 1000 1010 1020
LLLPGLENVE MMDESSEPYS ESTENSQLNV KISGMERKSS GKRDSILAHT KDKKKKVKLS
1030 1040 1050 1060 1070 1080
AKLKLESSSP KIKSGKLLEE EKSTDFVFIP PEGKETKARV LTEHQKEVLK TKRCDIPALY
1090 1100 1110 1120 1130 1140
NNLDASQDTL FSAQFSQEES MESLTLTEKP KEDAKIIKEE QMESTIFIHQ DAPENCGIDE
1150 1160 1170 1180 1190 1200
HSENASLPNC GGSVAETNPE TLITGFDARK EVLISSKILS AESSSSTETS VVSSSSVSNA
1210 1220 1230 1240 1250 1260
TFSGTPPQPT SRRQTFITLE KFDGSETRPF SPSPLNNISS TVTVRNNQDN TTNTDMPPKA
1270 1280 1290 1300 1310 1320
RKREVTNSKS DSENLANAGK KSSRRWSKAE QSVTKKSKPS LTSEQEEHSS ENNSPDLLSP
1330 1340 1350 1360 1370 1380
TEHVSENDDH PSEATLEHKD GDPKPAVENA SLEDLTTEEK NVGINMESKE STASVVARTE
1390 1400 1410 1420 1430 1440
QIVNEDSQAA ALAPNPKTLR RSSRRRSEAV DSCSDSQERE SGQQKKERRK EEEKIISKSP
1450 1460 1470 1480 1490 1500
LRIKDDKLPT QKLTDESPIQ ENLTEKGNTL PERTSGEPSV NAEIDQNRRK PDLENVSSEG
1510 1520 1530 1540 1550 1560
GGGTLDNLDK SSEKPLRGRT RYQTRRASQG LISAVENSES DSSEAKEEVS RKKRSGKWKN
1570 1580 1590 1600 1610 1620
RSSDSVDIEE QEEKKAEEEV MKTANQTLDG QAVPDVDVNA AAQVCEKSTN NNRVILQDSA
1630 1640 1650 1660 1670 1680
GPADSLQAPP KGEEKSKINK CVDSSFVSLP VPESNLRTRN ASKRLLYKQD NDSNVRVSDS
1690 1700 1710 1720 1730 1740
SLSPEKFTQV ECQHKRSRRV RRSKSCDCCG EKSQSQEKSF IGLKNTESYA IKSVEKKKTD
1750 1760 1770 1780 1790 1800
LQVPETAPET REARDHAETK LAGEEPLVNF HVGLKEENCT TGDSVKSEAE LQEASLPPEI
1810 1820 1830 1840 1850 1860
VTVKEKTYDT DASEAVSEIQ GPCSENHSPA EDPGLSECKD ISQKQLSENG ELDISDVGKA
1870 1880 1890 1900 1910 1920
CKVIAGSSPE GVETMELNVR NDAFVAADSE KSTQMDVSVD VATEEDNKKD ECEAVTTEVN
1930 1940 1950 1960 1970 1980
VEGVATEDFN SGMDLSDTPI PVSKDVETEH AASGEIEGES NESDSGSCEE MNKEMGSHKA
1990 2000 2010 2020 2030 2040
QMSTEIDSAR VKETDILASA SKSEEALIGR LDVNTQSFVS DIEMSSGERT VNCKTETSIE
2050 2060 2070 2080 2090 2100
LNKLDEAKLS GNEATVGNDT LQEVCFTSEK VEKLPQCLLV QVASELGAES NTTSPEKLEL
2110 2120 2130 2140 2150 2160
DSFGSVNESP SGMQQARCVW SPLASPSTSI LKRGLKRSQE DEISPVNKIR RVSFADPIYQ
2170 2180 2190 2200 2210 2220
AGLADDIDRR CSVVRSHSSN SSPIIKSVKT SPTSHSKHNT TSAKGFLSPG SQSSKFKSPK
2230 2240 2250 2260 2270 2280
KCLITEMAQE SMLSPTESVY PALVNCAASV DIILPQITSN MWARGLGQLI RAKNIKTIGD
2290 2300 2310 2320 2330 2340
LSTLTASEIK TLPIRSPKVF NVKKALRVYH EQQMKSRGLE EIPIFDISEK AVNGVESRTV
2350 2360 2370 2380 2390 2400
STDEERFASD LIEPVTLDTP LSKNLVAQIS ALALQLDSED LYSYTGSQLF EMHEKLGTMA
2410
NSIIRNLQSR WRSPAHENS
Isoforms
- Isoform 2 of Telomere-associated protein RIF1 - Isoform 3 of Telomere-associated protein RIF1Sequence View
10 20 30 40 50 60
MTAPGRSPLE PLLETWEDPS VPPGEQTDAY LTLTSRMTGE EGKEVIAEIE KNLSRLYTVL
70 80 90 100 110 120
KAHISSQNSE LSSAALQALG FCLYNPRITS GLSEANIQEL LLTLNGIIKS SDKNVCTRAL
130 140 150 160 170 180
WVISKQTFPA ELVSKMVSSI IDSLEVILSK GEIHSAVVDF EALNVIIRLI EQAPVQMGEE
190 200 210 220 230 240
SVRWAKLVIP LVVHSAQKVH LRGATALEMG MPLLLQKQQE IALITEHLMT TKLISELQKL
250 260 270 280 290 300
FKNKNETYVL KLWPLFVKLL GKTLHRSGSF INSLLQLEEL GFRSGTPMIK KIAFIAWKSL
310 320 330 340 350 360
IDNFALNPDI LCSAKRLKLL MQPLSSIHVR TETLALTKLE VWWYLLMRLG PQLPANFEQV
370 380 390 400 410 420
CVPLIQSTIS VDSIPSPQGN SSRGSASPGL SPLTPGHKGA SPYGSPRGNL SSNTGGMAAI
430 440 450 460 470 480
PSIQLLGLEM MLHFLLGPEV LSFAKQHKIV LSLEPLEHPL ISSPSFFSKY AHTLITAVHD
490 500 510 520 530 540
SFVSVGKDAS DAVVSAIWKE LISLVKSVTE AGNRKEKSGS EVLTLLLKSL ENIVKSEVFP
550 560 570 580 590 600
VSKTLVLMEI TVKGLPPKVL GSPAYQVANM DILNGTPALF LIQLIFNNNL LECGVEDEKF
610 620 630 640 650 660
FLNLETLVGC VLSGPTSPLA FSDSVLTVIN QNAKQLVNKE HLWRMWSMIV SPLTDVIHQT
670 680 690 700 710 720
NEVNQGDALE HNFSAIYGAL TLPINHIFSA QTFPTGTMKA LLKTWSELYR AFTRCASLVA
730 740 750 760 770 780
TAEENLCCEE LSSKIMCSLE DEVLSDLLFL DRISHIIIVM VDCIDFSPYN KKYQPKIKSP
790 800 810 820 830 840
QRSSDWSRKK KEPLGKLASL FKLIVKVIDT FHTLSLKETF SDTLLAIGNS IISMLSNVFG
850 860 870 880 890 900
HISLPSMIRE IFATFTRPLA LLYENSKLDE APKVYTSLNN KLEKLLGEIV ACLQFSYLGA
910 920 930 940 950 960
YDSELLEHLS PLLCVIFLHK NKQIRKQSAL LWNATFAKAT ALVYPEELKP ILRQAKQKIL
970 980 990 1000 1010 1020
LLLPGLENVE MMDESSEPYS ESTENSQLNV KISGMERKSS GKRDSILAHT KDKKKKVKLS
1030 1040 1050 1060 1070 1080
AKLKLESSSP KIKSGKLLEE EKSTDFVFIP PEGKETKARV LTEHQKEVLK TKRCDIPALY
1090 1100 1110 1120 1130 1140
NNLDASQDTL FSAQFSQEES MESLTLTEKP KEDAKIIKEE QMESTIFIHQ DAPENCGIDE
1150 1160 1170 1180 1190 1200
HSENASLPNC GGSVAETNPE TLITGFDARK EVLISSKILS AESSSSTETS VVSSSSVSNA
1210 1220 1230 1240 1250 1260
TFSGTPPQPT SRRQTFITLE KFDGSETRPF SPSPLNNISS TVTVRNNQDN TTNTDMPPKA
1270 1280 1290 1300 1310 1320
RKREVTNSKS DSENLANAGK KSSRRWSKAE QSVTKKSKPS LTSEQEEHSS ENNSPDLLSP
1330 1340 1350 1360 1370 1380
TEHVSENDDH PSEATLEHKD GDPKPAVENA SLEDLTTEEK NVGINMESKE STASVVARTE
1390 1400 1410 1420 1430 1440
QIVNEDSQAA ALAPNPKTLR RSSRRRSEAV DSCSDSQERE SGQQKKERRK EEEKIISKSP
1450 1460 1470 1480 1490 1500
LRIKDDKLPT QKLTDESPIQ ENLTEKGNTL PERTSGEPSV NAEIDQNRRK PDLENVSSEG
1510 1520 1530 1540 1550 1560
GGGTLDNLDK SSEKPLRGRT RYQTRRASQG LISAVENSES DSSEAKEEVS RKKRSGKWKN
1570 1580 1590 1600 1610 1620
RSSDSVDIEE QEEKKAEEEV MKTANQTLDG QAVPDVDVNA AAQVCEKSTN NNRVILQDSA
1630 1640 1650 1660 1670 1680
GPADSLQAPP KGEEKSKINK CVDSSFVSLP VPESNLRTRN ASKRLLYKQD NDSNVRVSDS
1690 1700 1710 1720 1730 1740
SLSPEKFTQV ECQHKRSRRV RRSKSCDCCG EKSQSQEKSF IGLKNTESYA IKSVEKKKTD
1750 1760 1770 1780 1790 1800
LQVPETAPET REARDHAETK LAGEEPLVNF HVGLKEENCT TGDSVKSEAE LQEASLPPEI
1810 1820 1830 1840 1850 1860
VTVKEKTYDT DASEAVSEIQ GPCSENHSPA EDPGLSECKD ISQKQLSENG ELDISDVGKA
1870 1880 1890 1900 1910 1920
CKVIAGSSPE GVETMELNVR NDAFVAADSE KSTQMDVSVD VATEEDNKKD ECEAVTTEVN
1930 1940 1950 1960 1970 1980
VEGVATEDFN SGMDLSDTPI PVSKDVETEH AASGEIEGES NESDSGSCEE MNKEMGSHKA
1990 2000 2010 2020 2030 2040
QMSTEIDSAR VKETDILASA SKSEEALIGR LDVNTQSFVS DIEMSSGERT VNCKTETSIE
2050 2060 2070 2080 2090 2100
LNKLDEAKLS GNEATVGNDT LQEVCFTSEK VEKLPQCLLV QVASELGAES NTTSPEKLEL
2110 2120 2130 2140 2150 2160
DSFGSVNESP SGMQQARCVW SPLASPSTSI LKRGLKRSQE DEISPVNKIR RVSFADPIYQ
2170 2180 2190 2200 2210 2220
AGLADDIDRR CSVVRSHSSN SSPIIKSVKT SPTSHSKHNT TSAKGFLSPG SQSSKFKSPK
2230 2240 2250 2260 2270 2280
KCLITEMAQE SMLSPTESVY PALVNCAASV DIILPQITSN MWARGLGQLI RAKNIKTIGD
2290 2300 2310 2320 2330 2340
LSTLTASEIK TLPIRSPKVF NVKKALRVYH EQQMKSRGLE EIPIFDISEK AVNGVESRTV
2350 2360 2370 2380 2390 2400
STDEERFASD LIEPVTLDTP LSKNLVAQIS ALALQLDSED LYSYTGSQLF EMHEKLGTMA
2410
NSIIRNLQSR WRSPAHENS
10 20 30 40 50 60
MTAPGRSPLE PLLETWEDPS VPPGEQTDAY LTLTSRMTGE EGKEVIAEIE KNLSRLYTVL
70 80 90 100 110 120
KAHISSQNSE LSSAALQALG FCLYNPRITS GLSEANIQEL LLTLNGIIKS SDKNVCTRAL
130 140 150 160 170 180
WVISKQTFPA ELVSKMVSSI IDSLEVILSK GEIHSAVVDF EALNVIIRLI EQAPVQMGEE
190 200 210 220 230 240
SVRWAKLVIP LVVHSAQKVH LRGATALEMG MPLLLQKQQE IALITEHLMT TKLISELQKL
250 260 270 280 290 300
FKNKNETYVL KLWPLFVKLL GKTLHRSGSF INSLLQLEEL GFRSGTPMIK KIAFIAWKSL
310 320 330 340 350 360
IDNFALNPDI LCSAKRLKLL MQPLSSIHVR TETLALTKLE VWWYLLMRLG PQLPANFEQV
370 380 390 400 410 420
CVPLIQSTIS VDSIPSPQGN SSRGSASPGL SPLTPGHKGA SPYGSPRGNL SSNTGGMAAI
430 440 450 460 470 480
PSIQLLGLEM MLHFLLGPEV LSFAKQHKIV LSLEPLEHPL ISSPSFFSKY AHTLITAVHD
490 500 510 520 530 540
SFVSVGKDAS DAVVSAIWKE LISLVKSVTE AGNRKEKSGS EVLTLLLKSL ENIVKSEVFP
550 560 570 580 590 600
VSKTLVLMEI TVKGLPPKVL GSPAYQVANM DILNGTPALF LIQLIFNNNL LECGVEDEKF
610 620 630 640 650 660
FLNLETLVGC VLSGPTSPLA FSDSVLTVIN QNAKQLVNKE HLWRMWSMIV SPLTDVIHQT
670 680 690 700 710 720
NEVNQGDALE HNFSAIYGAL TLPINHIFSA QTFPTGTMKA LLKTWSELYR AFTRCASLVA
730 740 750 760 770 780
TAEENLCCEE LSSKIMCSLE DEVLSDLLFL DRISHIIIVM VDCIDFSPYN KKYQPKIKSP
790 800 810 820 830 840
QRSSDWSRKK KEPLGKLASL FKLIVKVIDT FHTLSLKETF SDTLLAIGNS IISMLSNVFG
850 860 870 880 890 900
HISLPSMIRE IFATFTRPLA LLYENSKLDE APKVYTSLNN KLEKLLGEIV ACLQFSYLGA
910 920 930 940 950 960
YDSELLEHLS PLLCVIFLHK NKQIRKQSAL LWNATFAKAT ALVYPEELKP ILRQAKQKIL
970 980 990 1000 1010 1020
LLLPGLENVE MMDESSEPYS ESTENSQLNV KISGMERKSS GKRDSILAHT KDKKKKVKLS
1030 1040 1050 1060 1070 1080
AKLKLESSSP KIKSGKLLEE EKSTDFVFIP PEGKETKARV LTEHQKEVLK TKRCDIPALY
1090 1100 1110 1120 1130 1140
NNLDASQDTL FSAQFSQEES MESLTLTEKP KEDAKIIKEE QMESTIFIHQ DAPENCGIDE
1150 1160 1170 1180 1190 1200
HSENASLPNC GGSVAETNPE TLITGFDARK EVLISSKILS AESSSSTETS VVSSSSVSNA
1210 1220 1230 1240 1250 1260
TFSGTPPQPT SRRQTFITLE KFDGSETRPF SPSPLNNISS TVTVRNNQDN TTNTDMPPKA
1270 1280 1290 1300 1310 1320
RKREVTNSKS DSENLANAGK KSSRRWSKAE QSVTKKSKPS LTSEQEEHSS ENNSPDLLSP
1330 1340 1350 1360 1370 1380
TEHVSENDDH PSEATLEHKD GDPKPAVENA SLEDLTTEEK NVGINMESKE STASVVARTE
1390 1400 1410 1420 1430 1440
QIVNEDSQAA ALAPNPKTLR RSSRRRSEAV DSCSDSQERE SGQQKKERRK EEEKIISKSP
1450 1460 1470 1480 1490 1500
LRIKDDKLPT QKLTDESPIQ ENLTEKGNTL PERTSGEPSV NAEIDQNRRK PDLENVSSEG
1510 1520 1530 1540 1550 1560
GGGTLDNLDK SSEKPLRGRT RYQTRRASQG LISAVENSES DSSEAKEEVS RKKRSGKWKN
1570 1580 1590 1600 1610 1620
RSSDSVDIEE QEEKKAEEEV MKTANQTLDG QAVPDVDVNA AAQVCEKSTN NNRVILQDSA
1630 1640 1650 1660 1670 1680
GPADSLQAPP KGEEKSKINK CVDSSFVSLP VPESNLRTRN ASKRLLYKQD NDSNVRVSDS
1690 1700 1710 1720 1730 1740
SLSPEKFTQV ECQHKRSRRV RRSKSCDCCG EKSQSQEKSF IGLKNTESYA IKSVEKKKTD
1750 1760 1770 1780 1790 1800
LQVPETAPET REARDHAETK LAGEEPLVNF HVGLKEENCT TGDSVKSEAE LQEASLPPEI
1810 1820 1830 1840 1850 1860
VTVKEKTYDT DASEAVSEIQ GPCSENHSPA EDPGLSECKD ISQKQLSENG ELDISDVGKA
1870 1880 1890 1900 1910 1920
CKVIAGSSPE GVETMELNVR NDAFVAADSE KSTQMDVSVD VATEEDNKKD ECEAVTTEVN
1930 1940 1950 1960 1970 1980
VEGVATEDFN SGMDLSDTPI PVSKDVETEH AASGEIEGES NESDSGSCEE MNKEMGSHKA
1990 2000 2010 2020 2030 2040
QMSTEIDSAR VKETDILASA SKSEEALIGR LDVNTQSFVS DIEMSSGERT VNCKTETSIE
2050 2060 2070 2080 2090 2100
LNKLDEAKLS GNEATVGNDT LQEVCFTSEK VEKLPQCLLV QVASELGAES NTTSPEKLEL
2110 2120 2130 2140 2150 2160
DSFGSVNESP SGMQQARCVW SPLASPSTSI LKRGLKRSQE DEISPVNKIR RVSFADPIYQ
2170 2180 2190 2200 2210 2220
AGLADDIDRR CSVVRSHSSN SSPIIKSVKT SPTSHSKHNT TSAKGFLSPG SQSSKFKSPK
2230 2240 2250 2260 2270 2280
KCLITEMAQE SMLSPTESVY PALVNCAASV DIILPQITSN MWARGLGQLI RAKNIKTIGD
2290 2300 2310 2320 2330 2340
LSTLTASEIK TLPIRSPKVF NVKKALRVYH EQQMKSRGLE EIPIFDISEK AVNGVESRTV
2350 2360 2370 2380 2390 2400
STDEERFASD LIEPVTLDTP LSKNLVAQIS ALALQLDSED LYSYTGSQLF EMHEKLGTMA
2410
NSIIRNLQSR WRSPAHENS
Protein Neighborhood
Domains & Features
1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| Q6PR54-1-unknown | MTAPGR... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| Q6PR54-1-unknown | MTAPGR... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt87725 | |||
| Q6PR54-1-unknown | MTAPGR... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt87726 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...AHENS | 2419 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| ...AHENS | 2419 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt83343 | |||
| ...AHENS | 2419 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt83344 |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|