Q6UWW8: Carboxylesterase 3

General Information

Protein names	- Carboxylesterase 3 - 3.1.1.1 - Liver carboxylesterase 31 homolog
Gene names	CES3
Organism	Homo sapiens
Protease Family
Protease ID	S09.958
Chromosome location
UniProt ID	Q6UWW8

3 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MERAVRVESG VLVGVVCLLL ACPATATGPE VAQPEVDTTL GRVRGRQVGV KGTDRLVNVF
        70         80         90        100        110        120
LGIPFAQPPL GPDRFSAPHP AQPWEGVRDA STAPPMCLQD VESMNSSRFV LNGKQQIFSV
       130        140        150        160        170        180
SEDCLVLNVY SPAEVPAGSG RPVMVWVHGG ALITGAATSY DGSALAAYGD VVVVTVQYRL
       190        200        210        220        230        240
GVLGFFSTGD EHAPGNQGFL DVVAALRWVQ ENIAPFGGDL NCVTVFGGSA GGSIISGLVL
       250        260        270        280        290        300
SPVAAGLFHR AITQSGVITT PGIIDSHPWP LAQKIANTLA CSSSSPAEMV QCLQQKEGEE
       310        320        330        340        350        360
LVLSKKLKNT IYPLTVDGTV FPKSPKELLK EKPFHSVPFL MGVNNHEFSW LIPRGWGLLD
       370        380        390        400        410        420
TMEQMSREDM LAISTPVLTS LDVPPEMMPT VIDEYLGSNS DAQAKCQAFQ EFMGDVFINV
       430        440        450        460        470        480
PTVSFSRYLR DSGSPVFFYE FQHRPSSFAK IKPAWVKADH GAEGAFVFGG PFLMDESSRL
       490        500        510        520        530        540
AFPEATEEEK QLSLTMMAQW THFARTGDPN SKALPPWPQF NQAEQYLEIN PVPRAGQKFR
       550        560        570
EAWMQFWSET LPSKIQQWHQ KQKNRKAQED L

Isoforms

- Isoform 2 of Carboxylesterase 3

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name	Publications (PMID)
Q6UWW8-27-unknown	TGPEVA...	27	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q6UWW8-362-unknown	MEQMSR...	362	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt74234
Q6UWW8-362-unknown	MEQMSR...	362	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000445559
Q6UWW8-565-unknown	RKAQED...	565		unknown		Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q6UWW8-565-unknown	RKAQED...	565	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt161513

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...AQEDL	571		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...AQEDL	571		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...AQEDL	571	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...AQEDL	571	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt69852
...AQEDL	571		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...AQEDL	571		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)