Q6XPS3: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2

General Information

Protein names	- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 - 3.1.3.67 - Lipid phosphatase TPIP - TPTE and PTEN homologous inositol lipid phosphatase
Gene names	TPTE2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q6XPS3

2 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 - Isoform 3 of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 - Isoform 4 of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 - Isoform 5 of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 - Isoform 6 of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 - Isoform 7 of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2

Sequence View

        10         20         30         40         50         60
MNESPQTNEF KGTTEEAPAK ESPHTSEFKG AALVSPISKS MLERLSKFEV EDAENVASYD
        70         80         90        100        110        120
SKIKKIVHSI VSSFAFGIFG VFLVLLDVTL LLADLIFTDS KLYIPLEYRS ISLAIGLFFL
       130        140        150        160        170        180
MDVLLRVFVE GRQQYFSDLF NILDTAIIVI PLLVDVIYIF FDIKLLRNIP RWTHLVRLLR
       190        200        210        220        230        240
LIILIRIFHL LHQKRQLEKL MRRLVSENKR RYTRDGFDLD LTYVTERIIA MSFPSSGRQS
       250        260        270        280        290        300
FYRNPIEEVV RFLDKKHRNH YRVYNLCSER AYDPKHFHNR VSRIMIDDHN VPTLHEMVVF
       310        320        330        340        350        360
TKEVNEWMAQ DLENIVAIHC KGGKGRTGTM VCALLIASEI FLTAEESLYY FGERRTNKTH
       370        380        390        400        410        420
SNKFQGVETP SQNRYVGYFA QVKHLYNWNL PPRRILFIKR FIIYSIRGDV CDLKVQVVME
       430        440        450        460        470        480
KKVVFSSTSL GNCSILHDIE TDKILINVYD GPPLYDDVKV QFFSSNLPKY YDNCPFFFWF
       490        500        510        520
NTSFIQNNRL CLPRNELDNP HKQKAWKIYP PEFAVEILFG EK         10         20         30         40         50         60
MNESPQTNEF KGTTEEAPAK ESPHTSEFKG AALVSPISKS MLERLSKFEV EDAENVASYD
        70         80         90        100        110        120
SKIKKIVHSI VSSFAFGIFG VFLVLLDVTL LLADLIFTDS KLYIPLEYRS ISLAIGLFFL
       130        140        150        160        170        180
MDVLLRVFVE GRQQYFSDLF NILDTAIIVI PLLVDVIYIF FDIKLLRNIP RWTHLVRLLR
       190        200        210        220        230        240
LIILIRIFHL LHQKRQLEKL MRRLVSENKR RYTRDGFDLD LTYVTERIIA MSFPSSGRQS
       250        260        270        280        290        300
FYRNPIEEVV RFLDKKHRNH YRVYNLCSER AYDPKHFHNR VSRIMIDDHN VPTLHEMVVF
       310        320        330        340        350        360
TKEVNEWMAQ DLENIVAIHC KGGKGRTGTM VCALLIASEI FLTAEESLYY FGERRTNKTH
       370        380        390        400        410        420
SNKFQGVETP SQNRYVGYFA QVKHLYNWNL PPRRILFIKR FIIYSIRGDV CDLKVQVVME
       430        440        450        460        470        480
KKVVFSSTSL GNCSILHDIE TDKILINVYD GPPLYDDVKV QFFSSNLPKY YDNCPFFFWF
       490        500        510        520
NTSFIQNNRL CLPRNELDNP HKQKAWKIYP PEFAVEILFG EK         10         20         30         40         50         60
MNESPQTNEF KGTTEEAPAK ESPHTSEFKG AALVSPISKS MLERLSKFEV EDAENVASYD
        70         80         90        100        110        120
SKIKKIVHSI VSSFAFGIFG VFLVLLDVTL LLADLIFTDS KLYIPLEYRS ISLAIGLFFL
       130        140        150        160        170        180
MDVLLRVFVE GRQQYFSDLF NILDTAIIVI PLLVDVIYIF FDIKLLRNIP RWTHLVRLLR
       190        200        210        220        230        240
LIILIRIFHL LHQKRQLEKL MRRLVSENKR RYTRDGFDLD LTYVTERIIA MSFPSSGRQS
       250        260        270        280        290        300
FYRNPIEEVV RFLDKKHRNH YRVYNLCSER AYDPKHFHNR VSRIMIDDHN VPTLHEMVVF
       310        320        330        340        350        360
TKEVNEWMAQ DLENIVAIHC KGGKGRTGTM VCALLIASEI FLTAEESLYY FGERRTNKTH
       370        380        390        400        410        420
SNKFQGVETP SQNRYVGYFA QVKHLYNWNL PPRRILFIKR FIIYSIRGDV CDLKVQVVME
       430        440        450        460        470        480
KKVVFSSTSL GNCSILHDIE TDKILINVYD GPPLYDDVKV QFFSSNLPKY YDNCPFFFWF
       490        500        510        520
NTSFIQNNRL CLPRNELDNP HKQKAWKIYP PEFAVEILFG EK         10         20         30         40         50         60
MNESPQTNEF KGTTEEAPAK ESPHTSEFKG AALVSPISKS MLERLSKFEV EDAENVASYD
        70         80         90        100        110        120
SKIKKIVHSI VSSFAFGIFG VFLVLLDVTL LLADLIFTDS KLYIPLEYRS ISLAIGLFFL
       130        140        150        160        170        180
MDVLLRVFVE GRQQYFSDLF NILDTAIIVI PLLVDVIYIF FDIKLLRNIP RWTHLVRLLR
       190        200        210        220        230        240
LIILIRIFHL LHQKRQLEKL MRRLVSENKR RYTRDGFDLD LTYVTERIIA MSFPSSGRQS
       250        260        270        280        290        300
FYRNPIEEVV RFLDKKHRNH YRVYNLCSER AYDPKHFHNR VSRIMIDDHN VPTLHEMVVF
       310        320        330        340        350        360
TKEVNEWMAQ DLENIVAIHC KGGKGRTGTM VCALLIASEI FLTAEESLYY FGERRTNKTH
       370        380        390        400        410        420
SNKFQGVETP SQNRYVGYFA QVKHLYNWNL PPRRILFIKR FIIYSIRGDV CDLKVQVVME
       430        440        450        460        470        480
KKVVFSSTSL GNCSILHDIE TDKILINVYD GPPLYDDVKV QFFSSNLPKY YDNCPFFFWF
       490        500        510        520
NTSFIQNNRL CLPRNELDNP HKQKAWKIYP PEFAVEILFG EK         10         20         30         40         50         60
MNESPQTNEF KGTTEEAPAK ESPHTSEFKG AALVSPISKS MLERLSKFEV EDAENVASYD
        70         80         90        100        110        120
SKIKKIVHSI VSSFAFGIFG VFLVLLDVTL LLADLIFTDS KLYIPLEYRS ISLAIGLFFL
       130        140        150        160        170        180
MDVLLRVFVE GRQQYFSDLF NILDTAIIVI PLLVDVIYIF FDIKLLRNIP RWTHLVRLLR
       190        200        210        220        230        240
LIILIRIFHL LHQKRQLEKL MRRLVSENKR RYTRDGFDLD LTYVTERIIA MSFPSSGRQS
       250        260        270        280        290        300
FYRNPIEEVV RFLDKKHRNH YRVYNLCSER AYDPKHFHNR VSRIMIDDHN VPTLHEMVVF
       310        320        330        340        350        360
TKEVNEWMAQ DLENIVAIHC KGGKGRTGTM VCALLIASEI FLTAEESLYY FGERRTNKTH
       370        380        390        400        410        420
SNKFQGVETP SQNRYVGYFA QVKHLYNWNL PPRRILFIKR FIIYSIRGDV CDLKVQVVME
       430        440        450        460        470        480
KKVVFSSTSL GNCSILHDIE TDKILINVYD GPPLYDDVKV QFFSSNLPKY YDNCPFFFWF
       490        500        510        520
NTSFIQNNRL CLPRNELDNP HKQKAWKIYP PEFAVEILFG EK         10         20         30         40         50         60
MNESPQTNEF KGTTEEAPAK ESPHTSEFKG AALVSPISKS MLERLSKFEV EDAENVASYD
        70         80         90        100        110        120
SKIKKIVHSI VSSFAFGIFG VFLVLLDVTL LLADLIFTDS KLYIPLEYRS ISLAIGLFFL
       130        140        150        160        170        180
MDVLLRVFVE GRQQYFSDLF NILDTAIIVI PLLVDVIYIF FDIKLLRNIP RWTHLVRLLR
       190        200        210        220        230        240
LIILIRIFHL LHQKRQLEKL MRRLVSENKR RYTRDGFDLD LTYVTERIIA MSFPSSGRQS
       250        260        270        280        290        300
FYRNPIEEVV RFLDKKHRNH YRVYNLCSER AYDPKHFHNR VSRIMIDDHN VPTLHEMVVF
       310        320        330        340        350        360
TKEVNEWMAQ DLENIVAIHC KGGKGRTGTM VCALLIASEI FLTAEESLYY FGERRTNKTH
       370        380        390        400        410        420
SNKFQGVETP SQNRYVGYFA QVKHLYNWNL PPRRILFIKR FIIYSIRGDV CDLKVQVVME
       430        440        450        460        470        480
KKVVFSSTSL GNCSILHDIE TDKILINVYD GPPLYDDVKV QFFSSNLPKY YDNCPFFFWF
       490        500        510        520
NTSFIQNNRL CLPRNELDNP HKQKAWKIYP PEFAVEILFG EK

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q6XPS3-1-unknown	MNESPQ...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q6XPS3-1-unknown	MNESPQ...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt92913
Q6XPS3-1-unknown	MNESPQ...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt92914
Q6XPS3-1-unknown	MNESPQ...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt92915
Q6XPS3-1-unknown	MNESPQ...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt92916
Q6XPS3-1-unknown	MNESPQ...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt92918
Q6XPS3-330-unknown	MVCALL...	330	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt92917
Q6XPS3-330-unknown	MVCALL...	330	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt109513
Q6XPS3-330-unknown	MVCALL...	330	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt109512
Q6XPS3-330-unknown	MVCALL...	330	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt109514
Q6XPS3-330-unknown	MVCALL...	330	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt109515
Q6XPS3-330-unknown	MVCALL...	330	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt109511

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LFGEK	522	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LFGEK	522	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt88535
...LFGEK	522	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt88534
...LFGEK	522	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt88532
...LFGEK	522	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt88531

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)