Q6ZN54: Differentially expressed in FDCP 8 homolog

General Information

Protein names	- Differentially expressed in FDCP 8 homolog - DEF-8
Gene names	DEF8
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q6ZN54

4 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Differentially expressed in FDCP 8 homolog - Isoform 3 of Differentially expressed in FDCP 8 homolog - Isoform 4 of Differentially expressed in FDCP 8 homolog - Isoform 5 of Differentially expressed in FDCP 8 homolog - Isoform 6 of Differentially expressed in FDCP 8 homolog

Sequence View

        10         20         30         40         50         60
MAILSLRAPG PWQAMQVWAD RTLLTPHTGV TSQVLGVAAA VMTPLPGGHA AGRTREARWD
        70         80         90        100        110        120
AMEYDEKLAR FRQAHLNPFN KQSGPRQHEQ GPGEEVPDVT PEEALPELPP GEPEFRCPER
       130        140        150        160        170        180
VMDLGLSEDH FSRPVGLFLA SDVQQLRQAI EECKQVILEL PEQSEKQKDA VVRLIHLRLK
       190        200        210        220        230        240
LQELKDPNED EPNIRVLLEH RFYKEKSKSV KQTCDKCNTI IWGLIQTWYT CTGCYYRCHS
       250        260        270        280        290        300
KCLNLISKPC VSSKVSHQAE YELNICPETG LDSQDYRCAE CRAPISLRGV PSEARQCDYT
       310        320        330        340        350        360
GQYYCSHCHW NDLAVIPARV VHNWDFEPRK VSRCSMRYLA LMVSRPVLRL REINPLLFSY
       370        380        390        400        410        420
VEELVEIRKL RQDILLMKPY FITCREAMEA RLLLQLQDRQ HFVENDEMYS VQDLLDVHAG
       430        440        450        460        470        480
RLGCSLTEIH TLFAKHIKLD CERCQAKGFV CELCREGDVL FPFDSHTSVC ADCSAVFHRD
       490        500        510
CYYDNSTTCP KCARLSLRKQ SLFQEPGPDV EA         10         20         30         40         50         60
MAILSLRAPG PWQAMQVWAD RTLLTPHTGV TSQVLGVAAA VMTPLPGGHA AGRTREARWD
        70         80         90        100        110        120
AMEYDEKLAR FRQAHLNPFN KQSGPRQHEQ GPGEEVPDVT PEEALPELPP GEPEFRCPER
       130        140        150        160        170        180
VMDLGLSEDH FSRPVGLFLA SDVQQLRQAI EECKQVILEL PEQSEKQKDA VVRLIHLRLK
       190        200        210        220        230        240
LQELKDPNED EPNIRVLLEH RFYKEKSKSV KQTCDKCNTI IWGLIQTWYT CTGCYYRCHS
       250        260        270        280        290        300
KCLNLISKPC VSSKVSHQAE YELNICPETG LDSQDYRCAE CRAPISLRGV PSEARQCDYT
       310        320        330        340        350        360
GQYYCSHCHW NDLAVIPARV VHNWDFEPRK VSRCSMRYLA LMVSRPVLRL REINPLLFSY
       370        380        390        400        410        420
VEELVEIRKL RQDILLMKPY FITCREAMEA RLLLQLQDRQ HFVENDEMYS VQDLLDVHAG
       430        440        450        460        470        480
RLGCSLTEIH TLFAKHIKLD CERCQAKGFV CELCREGDVL FPFDSHTSVC ADCSAVFHRD
       490        500        510
CYYDNSTTCP KCARLSLRKQ SLFQEPGPDV EA         10         20         30         40         50         60
MAILSLRAPG PWQAMQVWAD RTLLTPHTGV TSQVLGVAAA VMTPLPGGHA AGRTREARWD
        70         80         90        100        110        120
AMEYDEKLAR FRQAHLNPFN KQSGPRQHEQ GPGEEVPDVT PEEALPELPP GEPEFRCPER
       130        140        150        160        170        180
VMDLGLSEDH FSRPVGLFLA SDVQQLRQAI EECKQVILEL PEQSEKQKDA VVRLIHLRLK
       190        200        210        220        230        240
LQELKDPNED EPNIRVLLEH RFYKEKSKSV KQTCDKCNTI IWGLIQTWYT CTGCYYRCHS
       250        260        270        280        290        300
KCLNLISKPC VSSKVSHQAE YELNICPETG LDSQDYRCAE CRAPISLRGV PSEARQCDYT
       310        320        330        340        350        360
GQYYCSHCHW NDLAVIPARV VHNWDFEPRK VSRCSMRYLA LMVSRPVLRL REINPLLFSY
       370        380        390        400        410        420
VEELVEIRKL RQDILLMKPY FITCREAMEA RLLLQLQDRQ HFVENDEMYS VQDLLDVHAG
       430        440        450        460        470        480
RLGCSLTEIH TLFAKHIKLD CERCQAKGFV CELCREGDVL FPFDSHTSVC ADCSAVFHRD
       490        500        510
CYYDNSTTCP KCARLSLRKQ SLFQEPGPDV EA         10         20         30         40         50         60
MAILSLRAPG PWQAMQVWAD RTLLTPHTGV TSQVLGVAAA VMTPLPGGHA AGRTREARWD
        70         80         90        100        110        120
AMEYDEKLAR FRQAHLNPFN KQSGPRQHEQ GPGEEVPDVT PEEALPELPP GEPEFRCPER
       130        140        150        160        170        180
VMDLGLSEDH FSRPVGLFLA SDVQQLRQAI EECKQVILEL PEQSEKQKDA VVRLIHLRLK
       190        200        210        220        230        240
LQELKDPNED EPNIRVLLEH RFYKEKSKSV KQTCDKCNTI IWGLIQTWYT CTGCYYRCHS
       250        260        270        280        290        300
KCLNLISKPC VSSKVSHQAE YELNICPETG LDSQDYRCAE CRAPISLRGV PSEARQCDYT
       310        320        330        340        350        360
GQYYCSHCHW NDLAVIPARV VHNWDFEPRK VSRCSMRYLA LMVSRPVLRL REINPLLFSY
       370        380        390        400        410        420
VEELVEIRKL RQDILLMKPY FITCREAMEA RLLLQLQDRQ HFVENDEMYS VQDLLDVHAG
       430        440        450        460        470        480
RLGCSLTEIH TLFAKHIKLD CERCQAKGFV CELCREGDVL FPFDSHTSVC ADCSAVFHRD
       490        500        510
CYYDNSTTCP KCARLSLRKQ SLFQEPGPDV EA         10         20         30         40         50         60
MAILSLRAPG PWQAMQVWAD RTLLTPHTGV TSQVLGVAAA VMTPLPGGHA AGRTREARWD
        70         80         90        100        110        120
AMEYDEKLAR FRQAHLNPFN KQSGPRQHEQ GPGEEVPDVT PEEALPELPP GEPEFRCPER
       130        140        150        160        170        180
VMDLGLSEDH FSRPVGLFLA SDVQQLRQAI EECKQVILEL PEQSEKQKDA VVRLIHLRLK
       190        200        210        220        230        240
LQELKDPNED EPNIRVLLEH RFYKEKSKSV KQTCDKCNTI IWGLIQTWYT CTGCYYRCHS
       250        260        270        280        290        300
KCLNLISKPC VSSKVSHQAE YELNICPETG LDSQDYRCAE CRAPISLRGV PSEARQCDYT
       310        320        330        340        350        360
GQYYCSHCHW NDLAVIPARV VHNWDFEPRK VSRCSMRYLA LMVSRPVLRL REINPLLFSY
       370        380        390        400        410        420
VEELVEIRKL RQDILLMKPY FITCREAMEA RLLLQLQDRQ HFVENDEMYS VQDLLDVHAG
       430        440        450        460        470        480
RLGCSLTEIH TLFAKHIKLD CERCQAKGFV CELCREGDVL FPFDSHTSVC ADCSAVFHRD
       490        500        510
CYYDNSTTCP KCARLSLRKQ SLFQEPGPDV EA

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q6ZN54-1-unknown	MAILSL...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q6ZN54-1-acetylation	MAILSL...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q6ZN54-1-acetylation	MAILSL...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q6ZN54-62-unknown	MEYDEK...	62		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt72572
Q6ZN54-62-unknown	MEYDEK...	62		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt72573
Q6ZN54-62-unknown	MEYDEK...	62		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt72575
Q6ZN54-62-unknown	MEYDEK...	62		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt72576
Q6ZN54-122-unknown	MDLGLS...	122		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt72574
Q6ZN54-122-unknown	MDLGLS...	122		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt103031
Q6ZN54-122-unknown	MDLGLS...	122		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt103032
Q6ZN54-122-unknown	MDLGLS...	122		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt103033

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PDVEA	512	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...PDVEA	512	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt68192
...PDVEA	512	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt68194
...PDVEA	512	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt68191
...PDVEA	512	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt68193

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)