Q6ZUM4: Rho GTPase-activating protein 27

General Information

Protein names	- Rho GTPase-activating protein 27 - CIN85-associated multi-domain-containing Rho GTPase-activating protein 1 - Rho-type GTPase-activating protein 27 - SH3 domain-containing protein 20
Gene names	ARHGAP27
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q6ZUM4

8 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Rho GTPase-activating protein 27 - Isoform 3 of Rho GTPase-activating protein 27 - Isoform 4 of Rho GTPase-activating protein 27

Sequence View

        10         20         30         40         50         60
MAADVVGDVY VLVEHPFEYT GKDGRRVAIR PNERYRLLRR STEHWWHVRR EPGGRPFYLP
        70         80         90        100        110        120
AQYVRELPAL GNPAAAAPPG PHPSPAAPEP LAYDYRFVSA AATAGPDGAP EESGGRASSL
       130        140        150        160        170        180
CGPAQRGAAT QRSSLAPGLP ACLYLRPAAP VRPAQSLNDL ACAAVSPPAG LLGSSGSFKA
       190        200        210        220        230        240
CSVAGSWVCP RPLARSDSEN VYEVIQDLHV PPPEESAEQV DDPPEPVYAN IERQPRATSP
       250        260        270        280        290        300
GAAAAPLPSP VWETHTDAGT GRPYYYNPDT GVTTWESPFE AAEGAASPAT SPASVDSHVS
       310        320        330        340        350        360
LETEWGQYWD EESRRVFFYN PLTGETAWED EAENEPEEEL EMQPGLSPGS PGDPRPPTPE
       370        380        390        400        410        420
TDYPESLTSY PEEDYSPVGS FGEPGPTSPL TTPPGWSCHV SQDKQMLYTN HFTQEQWVRL
       430        440        450        460        470        480
EDPHGKPYFY NPEDSSVRWE LPQVPVPAPR SIHKSSQDGD TPAQASPPEE KVPAELDEVG
       490        500        510        520        530        540
SWEEVSPATA AVRTKTLDKA GVLHRTKTAD KGKRLRKKHW SASWTVLEGG VLTFFKDSKT
       550        560        570        580        590        600
SAAGGLRQPS KFSTPEYTVE LRGATLSWAP KDKSSRKNVL ELRSRDGSEY LIQHDSEAII
       610        620        630        640        650        660
STWHKAIAQG IQELSAELPP EESESSRVDF GSSERLGSWQ EKEEDARPNA AAPALGPVGL
       670        680        690        700        710        720
ESDLSKVRHK LRKFLQRRPT LQSLREKGYI KDQVFGCALA ALCERERSRV PRFVQQCIRA
       730        740        750        760        770        780
VEARGLDIDG LYRISGNLAT IQKLRYKVDH DERLDLDDGR WEDVHVITGA LKLFFRELPE
       790        800        810        820        830        840
PLFPFSHFRQ FIAAIKLQDQ ARRSRCVRDL VRSLPAPNHD TLRMLFQHLC RVIEHGEQNR
       850        860        870        880
MSVQSVAIVF GPTLLRPEVE ETSMPMTMVF QNQVVELILQ QCADIFPPH         10         20         30         40         50         60
MAADVVGDVY VLVEHPFEYT GKDGRRVAIR PNERYRLLRR STEHWWHVRR EPGGRPFYLP
        70         80         90        100        110        120
AQYVRELPAL GNPAAAAPPG PHPSPAAPEP LAYDYRFVSA AATAGPDGAP EESGGRASSL
       130        140        150        160        170        180
CGPAQRGAAT QRSSLAPGLP ACLYLRPAAP VRPAQSLNDL ACAAVSPPAG LLGSSGSFKA
       190        200        210        220        230        240
CSVAGSWVCP RPLARSDSEN VYEVIQDLHV PPPEESAEQV DDPPEPVYAN IERQPRATSP
       250        260        270        280        290        300
GAAAAPLPSP VWETHTDAGT GRPYYYNPDT GVTTWESPFE AAEGAASPAT SPASVDSHVS
       310        320        330        340        350        360
LETEWGQYWD EESRRVFFYN PLTGETAWED EAENEPEEEL EMQPGLSPGS PGDPRPPTPE
       370        380        390        400        410        420
TDYPESLTSY PEEDYSPVGS FGEPGPTSPL TTPPGWSCHV SQDKQMLYTN HFTQEQWVRL
       430        440        450        460        470        480
EDPHGKPYFY NPEDSSVRWE LPQVPVPAPR SIHKSSQDGD TPAQASPPEE KVPAELDEVG
       490        500        510        520        530        540
SWEEVSPATA AVRTKTLDKA GVLHRTKTAD KGKRLRKKHW SASWTVLEGG VLTFFKDSKT
       550        560        570        580        590        600
SAAGGLRQPS KFSTPEYTVE LRGATLSWAP KDKSSRKNVL ELRSRDGSEY LIQHDSEAII
       610        620        630        640        650        660
STWHKAIAQG IQELSAELPP EESESSRVDF GSSERLGSWQ EKEEDARPNA AAPALGPVGL
       670        680        690        700        710        720
ESDLSKVRHK LRKFLQRRPT LQSLREKGYI KDQVFGCALA ALCERERSRV PRFVQQCIRA
       730        740        750        760        770        780
VEARGLDIDG LYRISGNLAT IQKLRYKVDH DERLDLDDGR WEDVHVITGA LKLFFRELPE
       790        800        810        820        830        840
PLFPFSHFRQ FIAAIKLQDQ ARRSRCVRDL VRSLPAPNHD TLRMLFQHLC RVIEHGEQNR
       850        860        870        880
MSVQSVAIVF GPTLLRPEVE ETSMPMTMVF QNQVVELILQ QCADIFPPH         10         20         30         40         50         60
MAADVVGDVY VLVEHPFEYT GKDGRRVAIR PNERYRLLRR STEHWWHVRR EPGGRPFYLP
        70         80         90        100        110        120
AQYVRELPAL GNPAAAAPPG PHPSPAAPEP LAYDYRFVSA AATAGPDGAP EESGGRASSL
       130        140        150        160        170        180
CGPAQRGAAT QRSSLAPGLP ACLYLRPAAP VRPAQSLNDL ACAAVSPPAG LLGSSGSFKA
       190        200        210        220        230        240
CSVAGSWVCP RPLARSDSEN VYEVIQDLHV PPPEESAEQV DDPPEPVYAN IERQPRATSP
       250        260        270        280        290        300
GAAAAPLPSP VWETHTDAGT GRPYYYNPDT GVTTWESPFE AAEGAASPAT SPASVDSHVS
       310        320        330        340        350        360
LETEWGQYWD EESRRVFFYN PLTGETAWED EAENEPEEEL EMQPGLSPGS PGDPRPPTPE
       370        380        390        400        410        420
TDYPESLTSY PEEDYSPVGS FGEPGPTSPL TTPPGWSCHV SQDKQMLYTN HFTQEQWVRL
       430        440        450        460        470        480
EDPHGKPYFY NPEDSSVRWE LPQVPVPAPR SIHKSSQDGD TPAQASPPEE KVPAELDEVG
       490        500        510        520        530        540
SWEEVSPATA AVRTKTLDKA GVLHRTKTAD KGKRLRKKHW SASWTVLEGG VLTFFKDSKT
       550        560        570        580        590        600
SAAGGLRQPS KFSTPEYTVE LRGATLSWAP KDKSSRKNVL ELRSRDGSEY LIQHDSEAII
       610        620        630        640        650        660
STWHKAIAQG IQELSAELPP EESESSRVDF GSSERLGSWQ EKEEDARPNA AAPALGPVGL
       670        680        690        700        710        720
ESDLSKVRHK LRKFLQRRPT LQSLREKGYI KDQVFGCALA ALCERERSRV PRFVQQCIRA
       730        740        750        760        770        780
VEARGLDIDG LYRISGNLAT IQKLRYKVDH DERLDLDDGR WEDVHVITGA LKLFFRELPE
       790        800        810        820        830        840
PLFPFSHFRQ FIAAIKLQDQ ARRSRCVRDL VRSLPAPNHD TLRMLFQHLC RVIEHGEQNR
       850        860        870        880
MSVQSVAIVF GPTLLRPEVE ETSMPMTMVF QNQVVELILQ QCADIFPPH

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

8 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q6ZUM4-1-unknown	MAADVV...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q6ZUM4-1-unknown	MAADVV...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt87661
Q6ZUM4-1-unknown	MAADVV...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt87662
Q6ZUM4-164-unknown	AVSPPA...	164	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175772
Q6ZUM4-164-unknown	AVSPPA...	164	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175773
Q6ZUM4-164-	AVSPPA...	164		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q6ZUM4-342-unknown	MQPGLS...	342	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt87660
Q6ZUM4-342-unknown	MQPGLS...	342	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000366121
Q6ZUM4-342-unknown	MQPGLS...	342	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000431591
Q6ZUM4-342-unknown	MQPGLS...	342	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000408235
Q6ZUM4-342-unknown	MQPGLS...	342	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt102036
Q6ZUM4-638-	SWQEKE...	638		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q6ZUM4-638-	SWQEKE...	638		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q6ZUM4-638-unknown	SWQEKE...	638	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167444
Q6ZUM4-638-unknown	SWQEKE...	638	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167443
Q6ZUM4-651-	AAPALG...	651		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q6ZUM4-651-unknown	AAPALG...	651	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167441
Q6ZUM4-651-unknown	AAPALG...	651	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167440

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PPEEKV	471	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000437100
...IFPPH	889	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...IFPPH	889	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt83278
...IFPPH	889	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt83279

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)