TopFIND 4.0

Q6ZVN8: Hemojuvelin {ECO:0000305}

General Information

Protein names
- Hemojuvelin {ECO:0000305}
- Hemochromatosis type 2 protein
- Hemojuvelin BMP coreceptor {ECO:0000305}
- RGM domain family member C
Gene names HFE2
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q6ZVN8

3

N-termini

2

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MGEPGQSPSP RSSHGSPPTL STLTLLLLLC GHAHSQCKIL RCNAEYVSST LSLRGGGSSG 
        70         80         90        100        110        120 
ALRGGGGGGR GGGVGSGGLC RALRSYALCT RRTARTCRGD LAFHSAVHGI EDLMIQHNCS 
       130        140        150        160        170        180 
RQGPTAPPPP RGPALPGAGS GLPAPDPCDY EGRFSRLHGR PPGFLHCASF GDPHVRSFHH 
       190        200        210        220        230        240 
HFHTCRVQGA WPLLDNDFLF VQATSSPMAL GANATATRKL TIIFKNMQEC IDQKVYQAEV 
       250        260        270        280        290        300 
DNLPVAFEDG SINGGDRPGG SSLSIQTANP GNHVEIQAAY IGTTIIIRQT AGQLSFSIKV 
       310        320        330        340        350        360 
AEDVAMAFSA EQDLQLCVGG CPPSQRLSRS ERNRRGAITI DTARRLCKEG LPVEDAYFHS 
       370        380        390        400        410        420 
CVFDVLISGD PNFTVAAQAA LEDARAFLPD LEKLHLFPSD AGVPLSSATL LAPLLSGLFV 
   
LWLCIQ

Isoforms

- Isoform b of Hemojuvelin - Isoform c of Hemojuvelin

Sequence View

        10         20         30         40         50         60 
MGEPGQSPSP RSSHGSPPTL STLTLLLLLC GHAHSQCKIL RCNAEYVSST LSLRGGGSSG 
        70         80         90        100        110        120 
ALRGGGGGGR GGGVGSGGLC RALRSYALCT RRTARTCRGD LAFHSAVHGI EDLMIQHNCS 
       130        140        150        160        170        180 
RQGPTAPPPP RGPALPGAGS GLPAPDPCDY EGRFSRLHGR PPGFLHCASF GDPHVRSFHH 
       190        200        210        220        230        240 
HFHTCRVQGA WPLLDNDFLF VQATSSPMAL GANATATRKL TIIFKNMQEC IDQKVYQAEV 
       250        260        270        280        290        300 
DNLPVAFEDG SINGGDRPGG SSLSIQTANP GNHVEIQAAY IGTTIIIRQT AGQLSFSIKV 
       310        320        330        340        350        360 
AEDVAMAFSA EQDLQLCVGG CPPSQRLSRS ERNRRGAITI DTARRLCKEG LPVEDAYFHS 
       370        380        390        400        410        420 
CVFDVLISGD PNFTVAAQAA LEDARAFLPD LEKLHLFPSD AGVPLSSATL LAPLLSGLFV 
   
LWLCIQ         10         20         30         40         50         60 
MGEPGQSPSP RSSHGSPPTL STLTLLLLLC GHAHSQCKIL RCNAEYVSST LSLRGGGSSG 
        70         80         90        100        110        120 
ALRGGGGGGR GGGVGSGGLC RALRSYALCT RRTARTCRGD LAFHSAVHGI EDLMIQHNCS 
       130        140        150        160        170        180 
RQGPTAPPPP RGPALPGAGS GLPAPDPCDY EGRFSRLHGR PPGFLHCASF GDPHVRSFHH 
       190        200        210        220        230        240 
HFHTCRVQGA WPLLDNDFLF VQATSSPMAL GANATATRKL TIIFKNMQEC IDQKVYQAEV 
       250        260        270        280        290        300 
DNLPVAFEDG SINGGDRPGG SSLSIQTANP GNHVEIQAAY IGTTIIIRQT AGQLSFSIKV 
       310        320        330        340        350        360 
AEDVAMAFSA EQDLQLCVGG CPPSQRLSRS ERNRRGAITI DTARRLCKEG LPVEDAYFHS 
       370        380        390        400        410        420 
CVFDVLISGD PNFTVAAQAA LEDARAFLPD LEKLHLFPSD AGVPLSSATL LAPLLSGLFV 
   
LWLCIQ



Filter Information:


(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


Database:


Lab:



Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q6ZVN8-36-unknown QCKILR... 36 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q6ZVN8-114-unknown MIQHNC... 114 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt87427
    Q6ZVN8-227-unknown MQECID... 227 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt87428
    Q6ZVN8-227-unknown MQECID... 227 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt103391

C-termini

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)