Q7L5N1: COP9 signalosome complex subunit 6

General Information

Protein names	- COP9 signalosome complex subunit 6 - SGN6 - Signalosome subunit 6 - JAB1-containing signalosome subunit 6 - MOV34 homolog - Vpr-interacting protein - hVIP
Gene names	COPS6
Organism	Homo sapiens
Protease Family
Protease ID	M67.972
Chromosome location
UniProt ID	Q7L5N1

3 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAAAAAAAA TNGTGGSSGM EVDAAVVPSV MACGVTGSVS VALHPLVILN ISDHWIRMRS
        70         80         90        100        110        120
QEGRPVQVIG ALIGKQEGRN IEVMNSFELL SHTVEEKIII DKEYYYTKEE QFKQVFKELE
       130        140        150        160        170        180
FLGWYTTGGP PDPSDIHVHK QVCEIIESPL FLKLNPMTKH TDLPVSVFES VIDIINGEAT
       190        200        210        220        230        240
MLFAELTYTL ATEEAERIGV DHVARMTATG SGENSTVAEH LIAQHSAIKM LHSRVKLILE
       250        260        270        280        290        300
YVKASEAGEV PFNHEILREA YALCHCLPVL STDKFKTDFY DQCNDVGLMA YLGTITKTCN
       310        320
TMNQFVNKFN VLYDRQGIGR RMRGLFF

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q7L5N1-1-unknown	MAAAAA...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q7L5N1-24-unknown	AAVVPS...	24	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2964
Q7L5N1-24-unknown	AAVVPS...	24	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2259
Q7L5N1-31-unknown	MACGVT...	31	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000388865

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GMEVDA	23	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2964
...GMEVDA	23	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2259
...QVIGAL	71	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000388865
...RGLFF	327	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP7_HUMAN	23	EVDA.\|.AAVV	inferred from experiment	unknown	MEROPS		Merops CASP7_HUMAN -> CSN6_HUMAN @23
CASP3_HUMAN	23	EVDA.\|.AAVV	inferred from experiment	unknown	MEROPS	Dubiel W	Hetfeld BK et al.:The COP9 signalosome-mediated d... (C14.003)	18060501,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)