Q7LDG7: RAS guanyl-releasing protein 2

General Information

Protein names	- RAS guanyl-releasing protein 2 - Calcium and DAG-regulated guanine nucleotide exchange factor I - CalDAG-GEFI - Cdc25-like protein - hCDC25L - F25B3.3 kinase-like protein
Gene names	RASGRP2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q7LDG7

3 N-termini

4 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of RAS guanyl-releasing protein 2 - Isoform 3 of RAS guanyl-releasing protein 2 - Isoform 4 of RAS guanyl-releasing protein 2

Sequence View

        10         20         30         40         50         60
MAGTLDLDKG CTVEELLRGC IEAFDDSGKV RDPQLVRMFL MMHPWYIPSS QLAAKLLHIY
        70         80         90        100        110        120
QQSRKDNSNS LQVKTCHLVR YWISAFPAEF DLNPELAEQI KELKALLDQE GNRRHSSLID
       130        140        150        160        170        180
IDSVPTYKWK RQVTQRNPVG QKKRKMSLLF DHLEPMELAE HLTYLEYRSF CKILFQDYHS
       190        200        210        220        230        240
FVTHGCTVDN PVLERFISLF NSVSQWVQLM ILSKPTAPQR ALVITHFVHV AEKLLQLQNF
       250        260        270        280        290        300
NTLMAVVGGL SHSSISRLKE THSHVSPETI KLWEGLTELV TATGNYGNYR RRLAACVGFR
       310        320        330        340        350        360
FPILGVHLKD LVALQLALPD WLDPARTRLN GAKMKQLFSI LEELAMVTSL RPPVQANPDL
       370        380        390        400        410        420
LSLLTVSLDQ YQTEDELYQL SLQREPRSKS SPTSPTSCTP PPRPPVLEEW TSAAKPKLDQ
       430        440        450        460        470        480
ALVVEHIEKM VESVFRNFDV DGDGHISQEE FQIIRGNFPY LSAFGDLDQN QDGCISREEM
       490        500        510        520        530        540
VSYFLRSSSV LGGRMGFVHN FQESNSLRPV ACRHCKALIL GIYKQGLKCR ACGVNCHKQC
       550        560        570        580        590        600
KDRLSVECRR RAQSVSLEGS APSPSPMHSH HHRAFSFSLP RPGRRGSRPP EIREEEVQTV

EDGVFDIHL         10         20         30         40         50         60
MAGTLDLDKG CTVEELLRGC IEAFDDSGKV RDPQLVRMFL MMHPWYIPSS QLAAKLLHIY
        70         80         90        100        110        120
QQSRKDNSNS LQVKTCHLVR YWISAFPAEF DLNPELAEQI KELKALLDQE GNRRHSSLID
       130        140        150        160        170        180
IDSVPTYKWK RQVTQRNPVG QKKRKMSLLF DHLEPMELAE HLTYLEYRSF CKILFQDYHS
       190        200        210        220        230        240
FVTHGCTVDN PVLERFISLF NSVSQWVQLM ILSKPTAPQR ALVITHFVHV AEKLLQLQNF
       250        260        270        280        290        300
NTLMAVVGGL SHSSISRLKE THSHVSPETI KLWEGLTELV TATGNYGNYR RRLAACVGFR
       310        320        330        340        350        360
FPILGVHLKD LVALQLALPD WLDPARTRLN GAKMKQLFSI LEELAMVTSL RPPVQANPDL
       370        380        390        400        410        420
LSLLTVSLDQ YQTEDELYQL SLQREPRSKS SPTSPTSCTP PPRPPVLEEW TSAAKPKLDQ
       430        440        450        460        470        480
ALVVEHIEKM VESVFRNFDV DGDGHISQEE FQIIRGNFPY LSAFGDLDQN QDGCISREEM
       490        500        510        520        530        540
VSYFLRSSSV LGGRMGFVHN FQESNSLRPV ACRHCKALIL GIYKQGLKCR ACGVNCHKQC
       550        560        570        580        590        600
KDRLSVECRR RAQSVSLEGS APSPSPMHSH HHRAFSFSLP RPGRRGSRPP EIREEEVQTV

EDGVFDIHL         10         20         30         40         50         60
MAGTLDLDKG CTVEELLRGC IEAFDDSGKV RDPQLVRMFL MMHPWYIPSS QLAAKLLHIY
        70         80         90        100        110        120
QQSRKDNSNS LQVKTCHLVR YWISAFPAEF DLNPELAEQI KELKALLDQE GNRRHSSLID
       130        140        150        160        170        180
IDSVPTYKWK RQVTQRNPVG QKKRKMSLLF DHLEPMELAE HLTYLEYRSF CKILFQDYHS
       190        200        210        220        230        240
FVTHGCTVDN PVLERFISLF NSVSQWVQLM ILSKPTAPQR ALVITHFVHV AEKLLQLQNF
       250        260        270        280        290        300
NTLMAVVGGL SHSSISRLKE THSHVSPETI KLWEGLTELV TATGNYGNYR RRLAACVGFR
       310        320        330        340        350        360
FPILGVHLKD LVALQLALPD WLDPARTRLN GAKMKQLFSI LEELAMVTSL RPPVQANPDL
       370        380        390        400        410        420
LSLLTVSLDQ YQTEDELYQL SLQREPRSKS SPTSPTSCTP PPRPPVLEEW TSAAKPKLDQ
       430        440        450        460        470        480
ALVVEHIEKM VESVFRNFDV DGDGHISQEE FQIIRGNFPY LSAFGDLDQN QDGCISREEM
       490        500        510        520        530        540
VSYFLRSSSV LGGRMGFVHN FQESNSLRPV ACRHCKALIL GIYKQGLKCR ACGVNCHKQC
       550        560        570        580        590        600
KDRLSVECRR RAQSVSLEGS APSPSPMHSH HHRAFSFSLP RPGRRGSRPP EIREEEVQTV

EDGVFDIHL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 4 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q7LDG7-1-unknown	MAGTLD...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q7LDG7-1-unknown	MAGTLD...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt76507
Q7LDG7-1-unknown	MAGTLD...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt76508
Q7LDG7-1-unknown	MAGTLD...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt99607
Q7LDG7-123-	SVPTYK...	123		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q7LDG7-123-	SVPTYK...	123		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q7LDG7-123-unknown	SVPTYK...	123	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168584
Q7LDG7-123-unknown	SVPTYK...	123	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168585

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VRYWIS	83	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000401314
...VRYWIS	83	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154145
...VRYWIS	83	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154146
...VRYWIS	83	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154147
...NPELAE	97	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000366705
...NPELAE	97	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154323
...NPELAE	97	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154324
...NPELAE	97	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154325
...VHVAEK	232	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000399114
...FDIHL	609	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...FDIHL	609	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72124

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)