TopFIND 4.0

Q7TMI3: E3 ubiquitin-protein ligase UHRF2

General Information

Protein names
- E3 ubiquitin-protein ligase UHRF2
- 2.3.2.27
- NIRF
- Np95-like ring finger protein
- Nuclear protein 97
- Nuclear zinc finger protein Np97
- RING-type E3 ubiquitin transferase UHRF2
- Ubiquitin-like PHD and RING finger domain-containing protein 2
- Ubiquitin-like-containing PHD and RING finger domains protein 2
Gene names Uhrf2
Organism Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID Q7TMI3

1

N-termini

2

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MWIQVRTIDG SQTRTIEDVS RKATIEELRE RVWALFDVRP ECQRLFYRGK QLENGYTLFD 
        70         80         90        100        110        120 
YDVGLNDIIQ LLVRPDSSLP STSKQNDAQV KPSSHNPPKV KKTARGGSSS QPSTSARTCL 
       130        140        150        160        170        180 
IDPGFGLYKV NELVDARDVG LGAWFEAHIH SVTRASDGHS RGKTPLKNGS SYKRTNGNVN 
       190        200        210        220        230        240 
HNSKENTNKL DNVPSTSNSD SVAADEDVIY HIEYDEYPES GILEMNVKDL RPRARTILKW 
       250        260        270        280        290        300 
NELNVGDVVM VNYNVENPGK RGFWYDAEIT TLKTISRTKK EVRVKVFLGG SEGTLNDCRV 
       310        320        330        340        350        360 
MSVDEIFKIE KPGAHPISFA DGKFLRKNDP ECDLCGGDPD KTCHMCSCHK CGEKRDPNMQ 
       370        380        390        400        410        420 
LLCDECNMAY HIYCLSPPLD KVPEEEYWYC PSCKTDSSEV VKAGERLKLS KKKAKMPSAS 
       430        440        450        460        470        480 
TESRRDWGRG MACVGRTKEC TIVPSNHYGP IPGIPVGSTW RFRVQVSEAG VHRPHVGGIH 
       490        500        510        520        530        540 
GRSNDGAYSL VLAGGFEDEV DRGDEFTYTG SGGKNLAGNK RIGAPSADQT LTNMNRALAL 
       550        560        570        580        590        600 
NCDAPLDDKI GAESRNWRAG KPVRVIRSFK GRKISKYAPE EGNRYDGIYK VVKYWPEISS 
       610        620        630        640        650        660 
SHGFLVWRYL LRRDDVEPAP WTSEGIERSR RLCLRLQYPA GYPSEKEGKK TKGQSKKQGS 
       670        680        690        700        710        720 
EATKRPASDD ECPGDSKVLK ASDSTDAVEA FQLTPQQQRL IREDCQNQKL WDEVLASLVE 
       730        740        750        760        770        780 
GPNFLKKLEQ SFMCVCCQEL VYQPVTTECF HNVCKDCLQR SFKAQVFSCP ACRHDLGQNY 
       790        800    
VMVLNETLQT LLDLFFPGYS KGR

Isoforms

- Isoform 2 of E3 ubiquitin-protein ligase UHRF2 - Isoform 3 of E3 ubiquitin-protein ligase UHRF2

Sequence View

        10         20         30         40         50         60 
MWIQVRTIDG SQTRTIEDVS RKATIEELRE RVWALFDVRP ECQRLFYRGK QLENGYTLFD 
        70         80         90        100        110        120 
YDVGLNDIIQ LLVRPDSSLP STSKQNDAQV KPSSHNPPKV KKTARGGSSS QPSTSARTCL 
       130        140        150        160        170        180 
IDPGFGLYKV NELVDARDVG LGAWFEAHIH SVTRASDGHS RGKTPLKNGS SYKRTNGNVN 
       190        200        210        220        230        240 
HNSKENTNKL DNVPSTSNSD SVAADEDVIY HIEYDEYPES GILEMNVKDL RPRARTILKW 
       250        260        270        280        290        300 
NELNVGDVVM VNYNVENPGK RGFWYDAEIT TLKTISRTKK EVRVKVFLGG SEGTLNDCRV 
       310        320        330        340        350        360 
MSVDEIFKIE KPGAHPISFA DGKFLRKNDP ECDLCGGDPD KTCHMCSCHK CGEKRDPNMQ 
       370        380        390        400        410        420 
LLCDECNMAY HIYCLSPPLD KVPEEEYWYC PSCKTDSSEV VKAGERLKLS KKKAKMPSAS 
       430        440        450        460        470        480 
TESRRDWGRG MACVGRTKEC TIVPSNHYGP IPGIPVGSTW RFRVQVSEAG VHRPHVGGIH 
       490        500        510        520        530        540 
GRSNDGAYSL VLAGGFEDEV DRGDEFTYTG SGGKNLAGNK RIGAPSADQT LTNMNRALAL 
       550        560        570        580        590        600 
NCDAPLDDKI GAESRNWRAG KPVRVIRSFK GRKISKYAPE EGNRYDGIYK VVKYWPEISS 
       610        620        630        640        650        660 
SHGFLVWRYL LRRDDVEPAP WTSEGIERSR RLCLRLQYPA GYPSEKEGKK TKGQSKKQGS 
       670        680        690        700        710        720 
EATKRPASDD ECPGDSKVLK ASDSTDAVEA FQLTPQQQRL IREDCQNQKL WDEVLASLVE 
       730        740        750        760        770        780 
GPNFLKKLEQ SFMCVCCQEL VYQPVTTECF HNVCKDCLQR SFKAQVFSCP ACRHDLGQNY 
       790        800    
VMVLNETLQT LLDLFFPGYS KGR         10         20         30         40         50         60 
MWIQVRTIDG SQTRTIEDVS RKATIEELRE RVWALFDVRP ECQRLFYRGK QLENGYTLFD 
        70         80         90        100        110        120 
YDVGLNDIIQ LLVRPDSSLP STSKQNDAQV KPSSHNPPKV KKTARGGSSS QPSTSARTCL 
       130        140        150        160        170        180 
IDPGFGLYKV NELVDARDVG LGAWFEAHIH SVTRASDGHS RGKTPLKNGS SYKRTNGNVN 
       190        200        210        220        230        240 
HNSKENTNKL DNVPSTSNSD SVAADEDVIY HIEYDEYPES GILEMNVKDL RPRARTILKW 
       250        260        270        280        290        300 
NELNVGDVVM VNYNVENPGK RGFWYDAEIT TLKTISRTKK EVRVKVFLGG SEGTLNDCRV 
       310        320        330        340        350        360 
MSVDEIFKIE KPGAHPISFA DGKFLRKNDP ECDLCGGDPD KTCHMCSCHK CGEKRDPNMQ 
       370        380        390        400        410        420 
LLCDECNMAY HIYCLSPPLD KVPEEEYWYC PSCKTDSSEV VKAGERLKLS KKKAKMPSAS 
       430        440        450        460        470        480 
TESRRDWGRG MACVGRTKEC TIVPSNHYGP IPGIPVGSTW RFRVQVSEAG VHRPHVGGIH 
       490        500        510        520        530        540 
GRSNDGAYSL VLAGGFEDEV DRGDEFTYTG SGGKNLAGNK RIGAPSADQT LTNMNRALAL 
       550        560        570        580        590        600 
NCDAPLDDKI GAESRNWRAG KPVRVIRSFK GRKISKYAPE EGNRYDGIYK VVKYWPEISS 
       610        620        630        640        650        660 
SHGFLVWRYL LRRDDVEPAP WTSEGIERSR RLCLRLQYPA GYPSEKEGKK TKGQSKKQGS 
       670        680        690        700        710        720 
EATKRPASDD ECPGDSKVLK ASDSTDAVEA FQLTPQQQRL IREDCQNQKL WDEVLASLVE 
       730        740        750        760        770        780 
GPNFLKKLEQ SFMCVCCQEL VYQPVTTECF HNVCKDCLQR SFKAQVFSCP ACRHDLGQNY 
       790        800    
VMVLNETLQT LLDLFFPGYS KGR



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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

1 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q7TMI3-1-unknown MWIQVR... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q7TMI3-1-unknown MWIQVR... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt93857
    Q7TMI3-1-unknown MWIQVR... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt93858

C-termini

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)