Q7TPQ3: E3 ubiquitin-protein ligase SHPRH
| Protein names | - E3 ubiquitin-protein ligase SHPRH - 2.3.2.27 - 3.6.4.- - RING-type E3 ubiquitin transferase SHPRH {ECO:0000305} - SNF2, histone-linker, PHD and RING finger domain-containing helicase |
|---|---|
| Gene names | Shprh |
| Organism | Mus musculus |
| Protease Family | |
| Protease ID | |
| Chromosome location | |
| UniProt ID | Q7TPQ3 |
1
N-termini
2
C-termini
0
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MSSRRKRAPP MKVDEERQQQ LHWNMHEDLR SEPLTMTVGE QACSDADSSS DCIIIDEGPP
70 80 90 100 110 120
ESALHRDKKR RSETVSVLEA TEEETRLSVT LNVTVSPYRV DNSWKAFLGD FALQLLPKES
130 140 150 160 170 180
LVEHFSERTF TLSPSESSSQ FLIYVHSECK NVEKQENVLE GSAGVCSKGI RVESSFSSDM
190 200 210 220 230 240
LQDLAWLQKR RGIKLYQRPD GTHTIKVGIY ILEAGLTRLD FMSDAGSRMK KFNQLMKRVM
250 260 270 280 290 300
EKLHNFIIPD VLEEEEEGSE SEPEGQDIDE LYHFVKQTHQ QETRSVQVDV QHPALIPVLR
310 320 330 340 350 360
PYQREAVNWM LQQEQFRSAP PADNSLHFLW REIVTPDGLK LYYNPYTGCI IRDFPHAGPQ
370 380 390 400 410 420
LLGGILADEM GLGKTVEVLA LILTHTRQDV KQDALTLPEG KVVNYFIPTH CPREKVKNRE
430 440 450 460 470 480
IQDTEYEPKE KVHCPPTRVM ILTAVKEMNG KKGVSILSIY KYVSSIFRYD VQRNRGLLKR
490 500 510 520 530 540
MLKCLIFEGL VKQIKGHGFS GTFTLGKNYK EDVFDKTKKQ AVGSPRKIEK ELRKSVNKDA
550 560 570 580 590 600
DSEYLPSNTS DDDEPYYYYC KAGKSRSKLK KPALLTKKGK GQSVHLDSQG DAPAAGVCAS
610 620 630 640 650 660
TDVHVSENTC VSEDKQTQEA KDCAESPNPA AEELAQSNTS SPCETSDYRF ECICGEFDQI
670 680 690 700 710 720
GHKPRVQCLK CHLWQHAKCV NYEEKNLKVK PFYCPHCLVA MEPVSTRATL IISPSSICHQ
730 740 750 760 770 780
WVDEINRHVR SSSLRVLVYQ GVKKHGFLQP HFLAEQDIVI ITYDVLRSEL NYVNIPHSNS
790 800 810 820 830 840
EDGRRLRNQK RYMAIPSPLV AVEWWRICLD EAQMVECPTV KAAEMAQRLS GINRWCISGT
850 860 870 880 890 900
PVQRGLEDLF GLVVFLGIEP YCVKHWWIRL LYHPYCKKNP QHLYSFIAKI MWRSAKKDVI
910 920 930 940 950 960
DQIQIPPQTE EMHWLHFSPV ERHFYHRQHE VCCQDAIVKL RKISDWALKL SSLDRRTVSS
970 980 990 1000 1010 1020
ILYPLLRLRQ ACCHPQAVRG EFLPLQKSTM TMEELLTSLQ KKCGTECEEA HRQLVCALNG
1030 1040 1050 1060 1070 1080
LAGIHIIKGE YALAAELYRE VLRSSEEHKG KLKTDSLQRL HATHNLMELL GAKHPGIPPT
1090 1100 1110 1120 1130 1140
LRDGRLEEEA KQLREHYMSK CNTEVAEAQQ ALQPVQQSIR ELQRKIHSNS PWWLNVIHRA
1150 1160 1170 1180 1190 1200
MEFSVDEELV QRVRNEISSN YKQQTDKLSM SEKFRDCRGL QFLLTTQMEE LHKFQKLVRE
1210 1220 1230 1240 1250 1260
AVKKLEKPPS REVIESATVC HLRPARLPLN CCVFCKADEL FTEYESKLFF NTVKGQTAIF
1270 1280 1290 1300 1310 1320
EEMIEDEEGL VDDRVPTTTR GLWAVSETER SMKAILSFAR SHRFDVEYVD EGSVSMDLFE
1330 1340 1350 1360 1370 1380
AWKKEYKLLH EYWMTLRNRV SAVDELAMAT ERLRVRHPKE PKPNPPVHHI IEPHEVEQNR
1390 1400 1410 1420 1430 1440
IKLVNDKAVA TSQLQKKLGQ LLYLTNLEKS QDKTSGGINP EPCPICARQL GKQWAVLTCG
1450 1460 1470 1480 1490 1500
HCFCNECTSI IIEQYSVGSH RSSIKCAICR QTTSHKEVSY VFTSEKANQE DDIPVKGSHS
1510 1520 1530 1540 1550 1560
TKVEAVVRTL MKIQLRDPGA KALVFSTWQD VLDIISKALT DNNMEFTQIS RIKTFQENLS
1570 1580 1590 1600 1610 1620
AFKYDPHINI LLLPLHTGSN GLTIIEATHV LLVEPILNPA HELQAIGRVH RIGQTKPTIV
1630 1640 1650 1660 1670
HRFLIKATIE ERMQAMLKTA ERSHTSSSGK HSEASVLTVA GLADLFTKEN EELE
Isoforms
- Isoform 2 of E3 ubiquitin-protein ligase SHPRH - Isoform 3 of E3 ubiquitin-protein ligase SHPRH - Isoform 4 of E3 ubiquitin-protein ligase SHPRHSequence View
10 20 30 40 50 60
MSSRRKRAPP MKVDEERQQQ LHWNMHEDLR SEPLTMTVGE QACSDADSSS DCIIIDEGPP
70 80 90 100 110 120
ESALHRDKKR RSETVSVLEA TEEETRLSVT LNVTVSPYRV DNSWKAFLGD FALQLLPKES
130 140 150 160 170 180
LVEHFSERTF TLSPSESSSQ FLIYVHSECK NVEKQENVLE GSAGVCSKGI RVESSFSSDM
190 200 210 220 230 240
LQDLAWLQKR RGIKLYQRPD GTHTIKVGIY ILEAGLTRLD FMSDAGSRMK KFNQLMKRVM
250 260 270 280 290 300
EKLHNFIIPD VLEEEEEGSE SEPEGQDIDE LYHFVKQTHQ QETRSVQVDV QHPALIPVLR
310 320 330 340 350 360
PYQREAVNWM LQQEQFRSAP PADNSLHFLW REIVTPDGLK LYYNPYTGCI IRDFPHAGPQ
370 380 390 400 410 420
LLGGILADEM GLGKTVEVLA LILTHTRQDV KQDALTLPEG KVVNYFIPTH CPREKVKNRE
430 440 450 460 470 480
IQDTEYEPKE KVHCPPTRVM ILTAVKEMNG KKGVSILSIY KYVSSIFRYD VQRNRGLLKR
490 500 510 520 530 540
MLKCLIFEGL VKQIKGHGFS GTFTLGKNYK EDVFDKTKKQ AVGSPRKIEK ELRKSVNKDA
550 560 570 580 590 600
DSEYLPSNTS DDDEPYYYYC KAGKSRSKLK KPALLTKKGK GQSVHLDSQG DAPAAGVCAS
610 620 630 640 650 660
TDVHVSENTC VSEDKQTQEA KDCAESPNPA AEELAQSNTS SPCETSDYRF ECICGEFDQI
670 680 690 700 710 720
GHKPRVQCLK CHLWQHAKCV NYEEKNLKVK PFYCPHCLVA MEPVSTRATL IISPSSICHQ
730 740 750 760 770 780
WVDEINRHVR SSSLRVLVYQ GVKKHGFLQP HFLAEQDIVI ITYDVLRSEL NYVNIPHSNS
790 800 810 820 830 840
EDGRRLRNQK RYMAIPSPLV AVEWWRICLD EAQMVECPTV KAAEMAQRLS GINRWCISGT
850 860 870 880 890 900
PVQRGLEDLF GLVVFLGIEP YCVKHWWIRL LYHPYCKKNP QHLYSFIAKI MWRSAKKDVI
910 920 930 940 950 960
DQIQIPPQTE EMHWLHFSPV ERHFYHRQHE VCCQDAIVKL RKISDWALKL SSLDRRTVSS
970 980 990 1000 1010 1020
ILYPLLRLRQ ACCHPQAVRG EFLPLQKSTM TMEELLTSLQ KKCGTECEEA HRQLVCALNG
1030 1040 1050 1060 1070 1080
LAGIHIIKGE YALAAELYRE VLRSSEEHKG KLKTDSLQRL HATHNLMELL GAKHPGIPPT
1090 1100 1110 1120 1130 1140
LRDGRLEEEA KQLREHYMSK CNTEVAEAQQ ALQPVQQSIR ELQRKIHSNS PWWLNVIHRA
1150 1160 1170 1180 1190 1200
MEFSVDEELV QRVRNEISSN YKQQTDKLSM SEKFRDCRGL QFLLTTQMEE LHKFQKLVRE
1210 1220 1230 1240 1250 1260
AVKKLEKPPS REVIESATVC HLRPARLPLN CCVFCKADEL FTEYESKLFF NTVKGQTAIF
1270 1280 1290 1300 1310 1320
EEMIEDEEGL VDDRVPTTTR GLWAVSETER SMKAILSFAR SHRFDVEYVD EGSVSMDLFE
1330 1340 1350 1360 1370 1380
AWKKEYKLLH EYWMTLRNRV SAVDELAMAT ERLRVRHPKE PKPNPPVHHI IEPHEVEQNR
1390 1400 1410 1420 1430 1440
IKLVNDKAVA TSQLQKKLGQ LLYLTNLEKS QDKTSGGINP EPCPICARQL GKQWAVLTCG
1450 1460 1470 1480 1490 1500
HCFCNECTSI IIEQYSVGSH RSSIKCAICR QTTSHKEVSY VFTSEKANQE DDIPVKGSHS
1510 1520 1530 1540 1550 1560
TKVEAVVRTL MKIQLRDPGA KALVFSTWQD VLDIISKALT DNNMEFTQIS RIKTFQENLS
1570 1580 1590 1600 1610 1620
AFKYDPHINI LLLPLHTGSN GLTIIEATHV LLVEPILNPA HELQAIGRVH RIGQTKPTIV
1630 1640 1650 1660 1670
HRFLIKATIE ERMQAMLKTA ERSHTSSSGK HSEASVLTVA GLADLFTKEN EELE
10 20 30 40 50 60
MSSRRKRAPP MKVDEERQQQ LHWNMHEDLR SEPLTMTVGE QACSDADSSS DCIIIDEGPP
70 80 90 100 110 120
ESALHRDKKR RSETVSVLEA TEEETRLSVT LNVTVSPYRV DNSWKAFLGD FALQLLPKES
130 140 150 160 170 180
LVEHFSERTF TLSPSESSSQ FLIYVHSECK NVEKQENVLE GSAGVCSKGI RVESSFSSDM
190 200 210 220 230 240
LQDLAWLQKR RGIKLYQRPD GTHTIKVGIY ILEAGLTRLD FMSDAGSRMK KFNQLMKRVM
250 260 270 280 290 300
EKLHNFIIPD VLEEEEEGSE SEPEGQDIDE LYHFVKQTHQ QETRSVQVDV QHPALIPVLR
310 320 330 340 350 360
PYQREAVNWM LQQEQFRSAP PADNSLHFLW REIVTPDGLK LYYNPYTGCI IRDFPHAGPQ
370 380 390 400 410 420
LLGGILADEM GLGKTVEVLA LILTHTRQDV KQDALTLPEG KVVNYFIPTH CPREKVKNRE
430 440 450 460 470 480
IQDTEYEPKE KVHCPPTRVM ILTAVKEMNG KKGVSILSIY KYVSSIFRYD VQRNRGLLKR
490 500 510 520 530 540
MLKCLIFEGL VKQIKGHGFS GTFTLGKNYK EDVFDKTKKQ AVGSPRKIEK ELRKSVNKDA
550 560 570 580 590 600
DSEYLPSNTS DDDEPYYYYC KAGKSRSKLK KPALLTKKGK GQSVHLDSQG DAPAAGVCAS
610 620 630 640 650 660
TDVHVSENTC VSEDKQTQEA KDCAESPNPA AEELAQSNTS SPCETSDYRF ECICGEFDQI
670 680 690 700 710 720
GHKPRVQCLK CHLWQHAKCV NYEEKNLKVK PFYCPHCLVA MEPVSTRATL IISPSSICHQ
730 740 750 760 770 780
WVDEINRHVR SSSLRVLVYQ GVKKHGFLQP HFLAEQDIVI ITYDVLRSEL NYVNIPHSNS
790 800 810 820 830 840
EDGRRLRNQK RYMAIPSPLV AVEWWRICLD EAQMVECPTV KAAEMAQRLS GINRWCISGT
850 860 870 880 890 900
PVQRGLEDLF GLVVFLGIEP YCVKHWWIRL LYHPYCKKNP QHLYSFIAKI MWRSAKKDVI
910 920 930 940 950 960
DQIQIPPQTE EMHWLHFSPV ERHFYHRQHE VCCQDAIVKL RKISDWALKL SSLDRRTVSS
970 980 990 1000 1010 1020
ILYPLLRLRQ ACCHPQAVRG EFLPLQKSTM TMEELLTSLQ KKCGTECEEA HRQLVCALNG
1030 1040 1050 1060 1070 1080
LAGIHIIKGE YALAAELYRE VLRSSEEHKG KLKTDSLQRL HATHNLMELL GAKHPGIPPT
1090 1100 1110 1120 1130 1140
LRDGRLEEEA KQLREHYMSK CNTEVAEAQQ ALQPVQQSIR ELQRKIHSNS PWWLNVIHRA
1150 1160 1170 1180 1190 1200
MEFSVDEELV QRVRNEISSN YKQQTDKLSM SEKFRDCRGL QFLLTTQMEE LHKFQKLVRE
1210 1220 1230 1240 1250 1260
AVKKLEKPPS REVIESATVC HLRPARLPLN CCVFCKADEL FTEYESKLFF NTVKGQTAIF
1270 1280 1290 1300 1310 1320
EEMIEDEEGL VDDRVPTTTR GLWAVSETER SMKAILSFAR SHRFDVEYVD EGSVSMDLFE
1330 1340 1350 1360 1370 1380
AWKKEYKLLH EYWMTLRNRV SAVDELAMAT ERLRVRHPKE PKPNPPVHHI IEPHEVEQNR
1390 1400 1410 1420 1430 1440
IKLVNDKAVA TSQLQKKLGQ LLYLTNLEKS QDKTSGGINP EPCPICARQL GKQWAVLTCG
1450 1460 1470 1480 1490 1500
HCFCNECTSI IIEQYSVGSH RSSIKCAICR QTTSHKEVSY VFTSEKANQE DDIPVKGSHS
1510 1520 1530 1540 1550 1560
TKVEAVVRTL MKIQLRDPGA KALVFSTWQD VLDIISKALT DNNMEFTQIS RIKTFQENLS
1570 1580 1590 1600 1610 1620
AFKYDPHINI LLLPLHTGSN GLTIIEATHV LLVEPILNPA HELQAIGRVH RIGQTKPTIV
1630 1640 1650 1660 1670
HRFLIKATIE ERMQAMLKTA ERSHTSSSGK HSEASVLTVA GLADLFTKEN EELE
10 20 30 40 50 60
MSSRRKRAPP MKVDEERQQQ LHWNMHEDLR SEPLTMTVGE QACSDADSSS DCIIIDEGPP
70 80 90 100 110 120
ESALHRDKKR RSETVSVLEA TEEETRLSVT LNVTVSPYRV DNSWKAFLGD FALQLLPKES
130 140 150 160 170 180
LVEHFSERTF TLSPSESSSQ FLIYVHSECK NVEKQENVLE GSAGVCSKGI RVESSFSSDM
190 200 210 220 230 240
LQDLAWLQKR RGIKLYQRPD GTHTIKVGIY ILEAGLTRLD FMSDAGSRMK KFNQLMKRVM
250 260 270 280 290 300
EKLHNFIIPD VLEEEEEGSE SEPEGQDIDE LYHFVKQTHQ QETRSVQVDV QHPALIPVLR
310 320 330 340 350 360
PYQREAVNWM LQQEQFRSAP PADNSLHFLW REIVTPDGLK LYYNPYTGCI IRDFPHAGPQ
370 380 390 400 410 420
LLGGILADEM GLGKTVEVLA LILTHTRQDV KQDALTLPEG KVVNYFIPTH CPREKVKNRE
430 440 450 460 470 480
IQDTEYEPKE KVHCPPTRVM ILTAVKEMNG KKGVSILSIY KYVSSIFRYD VQRNRGLLKR
490 500 510 520 530 540
MLKCLIFEGL VKQIKGHGFS GTFTLGKNYK EDVFDKTKKQ AVGSPRKIEK ELRKSVNKDA
550 560 570 580 590 600
DSEYLPSNTS DDDEPYYYYC KAGKSRSKLK KPALLTKKGK GQSVHLDSQG DAPAAGVCAS
610 620 630 640 650 660
TDVHVSENTC VSEDKQTQEA KDCAESPNPA AEELAQSNTS SPCETSDYRF ECICGEFDQI
670 680 690 700 710 720
GHKPRVQCLK CHLWQHAKCV NYEEKNLKVK PFYCPHCLVA MEPVSTRATL IISPSSICHQ
730 740 750 760 770 780
WVDEINRHVR SSSLRVLVYQ GVKKHGFLQP HFLAEQDIVI ITYDVLRSEL NYVNIPHSNS
790 800 810 820 830 840
EDGRRLRNQK RYMAIPSPLV AVEWWRICLD EAQMVECPTV KAAEMAQRLS GINRWCISGT
850 860 870 880 890 900
PVQRGLEDLF GLVVFLGIEP YCVKHWWIRL LYHPYCKKNP QHLYSFIAKI MWRSAKKDVI
910 920 930 940 950 960
DQIQIPPQTE EMHWLHFSPV ERHFYHRQHE VCCQDAIVKL RKISDWALKL SSLDRRTVSS
970 980 990 1000 1010 1020
ILYPLLRLRQ ACCHPQAVRG EFLPLQKSTM TMEELLTSLQ KKCGTECEEA HRQLVCALNG
1030 1040 1050 1060 1070 1080
LAGIHIIKGE YALAAELYRE VLRSSEEHKG KLKTDSLQRL HATHNLMELL GAKHPGIPPT
1090 1100 1110 1120 1130 1140
LRDGRLEEEA KQLREHYMSK CNTEVAEAQQ ALQPVQQSIR ELQRKIHSNS PWWLNVIHRA
1150 1160 1170 1180 1190 1200
MEFSVDEELV QRVRNEISSN YKQQTDKLSM SEKFRDCRGL QFLLTTQMEE LHKFQKLVRE
1210 1220 1230 1240 1250 1260
AVKKLEKPPS REVIESATVC HLRPARLPLN CCVFCKADEL FTEYESKLFF NTVKGQTAIF
1270 1280 1290 1300 1310 1320
EEMIEDEEGL VDDRVPTTTR GLWAVSETER SMKAILSFAR SHRFDVEYVD EGSVSMDLFE
1330 1340 1350 1360 1370 1380
AWKKEYKLLH EYWMTLRNRV SAVDELAMAT ERLRVRHPKE PKPNPPVHHI IEPHEVEQNR
1390 1400 1410 1420 1430 1440
IKLVNDKAVA TSQLQKKLGQ LLYLTNLEKS QDKTSGGINP EPCPICARQL GKQWAVLTCG
1450 1460 1470 1480 1490 1500
HCFCNECTSI IIEQYSVGSH RSSIKCAICR QTTSHKEVSY VFTSEKANQE DDIPVKGSHS
1510 1520 1530 1540 1550 1560
TKVEAVVRTL MKIQLRDPGA KALVFSTWQD VLDIISKALT DNNMEFTQIS RIKTFQENLS
1570 1580 1590 1600 1610 1620
AFKYDPHINI LLLPLHTGSN GLTIIEATHV LLVEPILNPA HELQAIGRVH RIGQTKPTIV
1630 1640 1650 1660 1670
HRFLIKATIE ERMQAMLKTA ERSHTSSSGK HSEASVLTVA GLADLFTKEN EELE
Protein Neighborhood
Domains & Features
1 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| Q7TPQ3-1-unknown | MSSRRK... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| Q7TPQ3-1-unknown | MSSRRK... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt89637 | |||
| Q7TPQ3-1-unknown | MSSRRK... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt89638 | |||
| Q7TPQ3-1-unknown | MSSRRK... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt89639 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...IGQTKP | 1616 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt85255 | |||
| ...IGQTKP | 1616 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt93772 | |||
| ...NEELE | 1674 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|