Q7Z434: Mitochondrial antiviral-signaling protein {ECO:0000305}

General Information

Protein names	- Mitochondrial antiviral-signaling protein {ECO:0000305} - MAVS {ECO:0000305} - CARD adapter inducing interferon beta - Cardif - Interferon beta promoter stimulator protein 1 - IPS-1 - Putative NF-kappa-B-activating protein 031N - Virus-induced-signaling adapter - VISA
Gene names	MAVS
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q7Z434

8 N-termini

2 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Mitochondrial antiviral-signaling protein - Isoform 3 of Mitochondrial antiviral-signaling protein - Isoform 4 of Mitochondrial antiviral-signaling protein - Isoform 5 of Mitochondrial antiviral-signaling protein - Isoform 6 of Mitochondrial antiviral-signaling protein

Sequence View

        10         20         30         40         50         60
MPFAEDKTYK YICRNFSNFC NVDVVEILPY LPCLTARDQD RLRATCTLSG NRDTLWHLFN
        70         80         90        100        110        120
TLQRRPGWVE YFIAALRGCE LVDLADEVAS VYQSYQPRTS DRPPDPLEPP SLPAERPGPP
       130        140        150        160        170        180
TPAAAHSIPY NSCREKEPSY PMPVQETQAP ESPGENSEQA LQTLSPRAIP RNPDGGPLES
       190        200        210        220        230        240
SSDLAALSPL TSSGHQEQDT ELGSTHTAGA TSSLTPSRGP VSPSVSFQPL ARSTPRASRL
       250        260        270        280        290        300
PGPTGSVVST GTSFSSSSPG LASAGAAEGK QGAESDQAEP IICSSGAEAP ANSLPSKVPT
       310        320        330        340        350        360
TLMPVNTVAL KVPANPASVS TVPSKLPTSS KPPGAVPSNA LTNPAPSKLP INSTRAGMVP
       370        380        390        400        410        420
SKVPTSMVLT KVSASTVPTD GSSRNEETPA APTPAGATGG SSAWLDSSSE NRGLGSELSK
       430        440        450        460        470        480
PGVLASQVDS PFSGCFEDLA ISASTSLGMG PCHGPEENEY KSEGTFGIHV AENPSIQLLE
       490        500        510        520        530        540
GNPGPPADPD GGPRPQADRK FQEREVPCHR PSPGALWLQV AVTGVLVVTL LVVLYRRRLH

        10         20         30         40         50         60
MPFAEDKTYK YICRNFSNFC NVDVVEILPY LPCLTARDQD RLRATCTLSG NRDTLWHLFN
        70         80         90        100        110        120
TLQRRPGWVE YFIAALRGCE LVDLADEVAS VYQSYQPRTS DRPPDPLEPP SLPAERPGPP
       130        140        150        160        170        180
TPAAAHSIPY NSCREKEPSY PMPVQETQAP ESPGENSEQA LQTLSPRAIP RNPDGGPLES
       190        200        210        220        230        240
SSDLAALSPL TSSGHQEQDT ELGSTHTAGA TSSLTPSRGP VSPSVSFQPL ARSTPRASRL
       250        260        270        280        290        300
PGPTGSVVST GTSFSSSSPG LASAGAAEGK QGAESDQAEP IICSSGAEAP ANSLPSKVPT
       310        320        330        340        350        360
TLMPVNTVAL KVPANPASVS TVPSKLPTSS KPPGAVPSNA LTNPAPSKLP INSTRAGMVP
       370        380        390        400        410        420
SKVPTSMVLT KVSASTVPTD GSSRNEETPA APTPAGATGG SSAWLDSSSE NRGLGSELSK
       430        440        450        460        470        480
PGVLASQVDS PFSGCFEDLA ISASTSLGMG PCHGPEENEY KSEGTFGIHV AENPSIQLLE
       490        500        510        520        530        540
GNPGPPADPD GGPRPQADRK FQEREVPCHR PSPGALWLQV AVTGVLVVTL LVVLYRRRLH

        10         20         30         40         50         60
MPFAEDKTYK YICRNFSNFC NVDVVEILPY LPCLTARDQD RLRATCTLSG NRDTLWHLFN
        70         80         90        100        110        120
TLQRRPGWVE YFIAALRGCE LVDLADEVAS VYQSYQPRTS DRPPDPLEPP SLPAERPGPP
       130        140        150        160        170        180
TPAAAHSIPY NSCREKEPSY PMPVQETQAP ESPGENSEQA LQTLSPRAIP RNPDGGPLES
       190        200        210        220        230        240
SSDLAALSPL TSSGHQEQDT ELGSTHTAGA TSSLTPSRGP VSPSVSFQPL ARSTPRASRL
       250        260        270        280        290        300
PGPTGSVVST GTSFSSSSPG LASAGAAEGK QGAESDQAEP IICSSGAEAP ANSLPSKVPT
       310        320        330        340        350        360
TLMPVNTVAL KVPANPASVS TVPSKLPTSS KPPGAVPSNA LTNPAPSKLP INSTRAGMVP
       370        380        390        400        410        420
SKVPTSMVLT KVSASTVPTD GSSRNEETPA APTPAGATGG SSAWLDSSSE NRGLGSELSK
       430        440        450        460        470        480
PGVLASQVDS PFSGCFEDLA ISASTSLGMG PCHGPEENEY KSEGTFGIHV AENPSIQLLE
       490        500        510        520        530        540
GNPGPPADPD GGPRPQADRK FQEREVPCHR PSPGALWLQV AVTGVLVVTL LVVLYRRRLH

        10         20         30         40         50         60
MPFAEDKTYK YICRNFSNFC NVDVVEILPY LPCLTARDQD RLRATCTLSG NRDTLWHLFN
        70         80         90        100        110        120
TLQRRPGWVE YFIAALRGCE LVDLADEVAS VYQSYQPRTS DRPPDPLEPP SLPAERPGPP
       130        140        150        160        170        180
TPAAAHSIPY NSCREKEPSY PMPVQETQAP ESPGENSEQA LQTLSPRAIP RNPDGGPLES
       190        200        210        220        230        240
SSDLAALSPL TSSGHQEQDT ELGSTHTAGA TSSLTPSRGP VSPSVSFQPL ARSTPRASRL
       250        260        270        280        290        300
PGPTGSVVST GTSFSSSSPG LASAGAAEGK QGAESDQAEP IICSSGAEAP ANSLPSKVPT
       310        320        330        340        350        360
TLMPVNTVAL KVPANPASVS TVPSKLPTSS KPPGAVPSNA LTNPAPSKLP INSTRAGMVP
       370        380        390        400        410        420
SKVPTSMVLT KVSASTVPTD GSSRNEETPA APTPAGATGG SSAWLDSSSE NRGLGSELSK
       430        440        450        460        470        480
PGVLASQVDS PFSGCFEDLA ISASTSLGMG PCHGPEENEY KSEGTFGIHV AENPSIQLLE
       490        500        510        520        530        540
GNPGPPADPD GGPRPQADRK FQEREVPCHR PSPGALWLQV AVTGVLVVTL LVVLYRRRLH

        10         20         30         40         50         60
MPFAEDKTYK YICRNFSNFC NVDVVEILPY LPCLTARDQD RLRATCTLSG NRDTLWHLFN
        70         80         90        100        110        120
TLQRRPGWVE YFIAALRGCE LVDLADEVAS VYQSYQPRTS DRPPDPLEPP SLPAERPGPP
       130        140        150        160        170        180
TPAAAHSIPY NSCREKEPSY PMPVQETQAP ESPGENSEQA LQTLSPRAIP RNPDGGPLES
       190        200        210        220        230        240
SSDLAALSPL TSSGHQEQDT ELGSTHTAGA TSSLTPSRGP VSPSVSFQPL ARSTPRASRL
       250        260        270        280        290        300
PGPTGSVVST GTSFSSSSPG LASAGAAEGK QGAESDQAEP IICSSGAEAP ANSLPSKVPT
       310        320        330        340        350        360
TLMPVNTVAL KVPANPASVS TVPSKLPTSS KPPGAVPSNA LTNPAPSKLP INSTRAGMVP
       370        380        390        400        410        420
SKVPTSMVLT KVSASTVPTD GSSRNEETPA APTPAGATGG SSAWLDSSSE NRGLGSELSK
       430        440        450        460        470        480
PGVLASQVDS PFSGCFEDLA ISASTSLGMG PCHGPEENEY KSEGTFGIHV AENPSIQLLE
       490        500        510        520        530        540
GNPGPPADPD GGPRPQADRK FQEREVPCHR PSPGALWLQV AVTGVLVVTL LVVLYRRRLH

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

8 N-termini - 2 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q7Z434-1-unknown	MPFAED...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q7Z434-1-unknown	MPFAED...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80488
Q7Z434-1-unknown	MPFAED...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80489
Q7Z434-1-unknown	MPFAED...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80491
Q7Z434-1-unknown	MPFAED...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80492
Q7Z434-2-unknown	PFAEDK...	2		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q7Z434-2-unknown	PFAEDK...	2	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178879
Q7Z434-2-unknown	PFAEDK...	2	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178880
Q7Z434-2-unknown	PFAEDK...	2	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178881
Q7Z434-2-unknown	PFAEDK...	2	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178882
Q7Z434-142-unknown	MPVQET...	142	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80490
Q7Z434-257-unknown	SSPGLA...	257	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178132
Q7Z434-257-	SSPGLA...	257		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q7Z434-430-unknown	SPFSGC...	430	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1314
Q7Z434-430-unknown	SPFSGC...	430	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2260
Q7Z434-430-unknown	SPFSGC...	430	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149557
Q7Z434-491-unknown	GGPRPQ...	491		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q7Z434-491-unknown	GGPRPQ...	491	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161796
Q7Z434-491-	GGPRPQ...	491		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q7Z434-491-	GGPRPQ...	491		Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ASQVDS	429	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1314
...ASQVDS	429	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2260
...ASQVDS	429	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132945
...RRRLH	540	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RRRLH	540	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76108

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP1_HUMAN	429	QVDS.\|.SPFS	inferred from experiment	unknown	MEROPS	Lin YL	Yu CY et al.:The interferon stimulator mitoc... (C14.001)	20032188,
CASP3_HUMAN	429	QVDS.\|.SPFS	inferred from experiment	unknown	MEROPS	Lin YL	Yu CY et al.:The interferon stimulator mitoc... (C14.001)	20032188,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)