Q7Z7A4: PX domain-containing protein kinase-like protein

General Information

Protein names	- PX domain-containing protein kinase-like protein - Modulator of Na,K-ATPase - MONaKA
Gene names	PXK
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q7Z7A4

6 N-termini

3 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of PX domain-containing protein kinase-like protein - Isoform 3 of PX domain-containing protein kinase-like protein - Isoform 4 of PX domain-containing protein kinase-like protein - Isoform 5 of PX domain-containing protein kinase-like protein - Isoform 6 of PX domain-containing protein kinase-like protein - Isoform 7 of PX domain-containing protein kinase-like protein

Sequence View

        10         20         30         40         50         60
MAFMEKPPAG KVLLDDTVPL TAAIEASQSL QSHTEYIIRV QRGISVENSW QIVRRYSDFD
        70         80         90        100        110        120
LLNNSLQIAG LSLPLPPKKL IGNMDREFIA ERQKGLQNYL NVITTNHILS NCELVKKFLD
       130        140        150        160        170        180
PNNYSANYTE IALQQVSMFF RSEPKWEVVE PLKDIGWRIR KKYFLMKIKN QPKERLVLSW
       190        200        210        220        230        240
ADLGPDKYLS DKDFQCLIKL LPSCLHPYIY RVTFATANES SALLIRMFNE KGTLKDLIYK
       250        260        270        280        290        300
AKPKDPFLKK YCNPKKIQGL ELQQIKTYGR QILEVLKFLH DKGFPYGHLH ASNVMLDGDT
       310        320        330        340        350        360
CRLLDLENSL LGLPSFYRSY FSQFRKINTL ESVDVHCFGH LLYEMTYGRP PDSVPVDSFP
       370        380        390        400        410        420
PAPSMAVVAV LESTLSCEAC KNGMPTISRL LQMPLFSDVL LTTSEKPQFK IPTKLKEALR
       430        440        450        460        470        480
IAKECIEKRL IEEQKQIHQH RRLTRAQSHH GSEEERKKRK ILARKKSKRS ALENSEEHSA
       490        500        510        520        530        540
KYSNSNNSAG SGASSPLTSP SSPTPPSTSG ISALPPPPPP PPPPAAPLPP ASTEAPAQLS
       550        560        570
SQAVNGMSRG ALLSSIQNFQ KGTLRKAKTC DHSAPKIG         10         20         30         40         50         60
MAFMEKPPAG KVLLDDTVPL TAAIEASQSL QSHTEYIIRV QRGISVENSW QIVRRYSDFD
        70         80         90        100        110        120
LLNNSLQIAG LSLPLPPKKL IGNMDREFIA ERQKGLQNYL NVITTNHILS NCELVKKFLD
       130        140        150        160        170        180
PNNYSANYTE IALQQVSMFF RSEPKWEVVE PLKDIGWRIR KKYFLMKIKN QPKERLVLSW
       190        200        210        220        230        240
ADLGPDKYLS DKDFQCLIKL LPSCLHPYIY RVTFATANES SALLIRMFNE KGTLKDLIYK
       250        260        270        280        290        300
AKPKDPFLKK YCNPKKIQGL ELQQIKTYGR QILEVLKFLH DKGFPYGHLH ASNVMLDGDT
       310        320        330        340        350        360
CRLLDLENSL LGLPSFYRSY FSQFRKINTL ESVDVHCFGH LLYEMTYGRP PDSVPVDSFP
       370        380        390        400        410        420
PAPSMAVVAV LESTLSCEAC KNGMPTISRL LQMPLFSDVL LTTSEKPQFK IPTKLKEALR
       430        440        450        460        470        480
IAKECIEKRL IEEQKQIHQH RRLTRAQSHH GSEEERKKRK ILARKKSKRS ALENSEEHSA
       490        500        510        520        530        540
KYSNSNNSAG SGASSPLTSP SSPTPPSTSG ISALPPPPPP PPPPAAPLPP ASTEAPAQLS
       550        560        570
SQAVNGMSRG ALLSSIQNFQ KGTLRKAKTC DHSAPKIG         10         20         30         40         50         60
MAFMEKPPAG KVLLDDTVPL TAAIEASQSL QSHTEYIIRV QRGISVENSW QIVRRYSDFD
        70         80         90        100        110        120
LLNNSLQIAG LSLPLPPKKL IGNMDREFIA ERQKGLQNYL NVITTNHILS NCELVKKFLD
       130        140        150        160        170        180
PNNYSANYTE IALQQVSMFF RSEPKWEVVE PLKDIGWRIR KKYFLMKIKN QPKERLVLSW
       190        200        210        220        230        240
ADLGPDKYLS DKDFQCLIKL LPSCLHPYIY RVTFATANES SALLIRMFNE KGTLKDLIYK
       250        260        270        280        290        300
AKPKDPFLKK YCNPKKIQGL ELQQIKTYGR QILEVLKFLH DKGFPYGHLH ASNVMLDGDT
       310        320        330        340        350        360
CRLLDLENSL LGLPSFYRSY FSQFRKINTL ESVDVHCFGH LLYEMTYGRP PDSVPVDSFP
       370        380        390        400        410        420
PAPSMAVVAV LESTLSCEAC KNGMPTISRL LQMPLFSDVL LTTSEKPQFK IPTKLKEALR
       430        440        450        460        470        480
IAKECIEKRL IEEQKQIHQH RRLTRAQSHH GSEEERKKRK ILARKKSKRS ALENSEEHSA
       490        500        510        520        530        540
KYSNSNNSAG SGASSPLTSP SSPTPPSTSG ISALPPPPPP PPPPAAPLPP ASTEAPAQLS
       550        560        570
SQAVNGMSRG ALLSSIQNFQ KGTLRKAKTC DHSAPKIG         10         20         30         40         50         60
MAFMEKPPAG KVLLDDTVPL TAAIEASQSL QSHTEYIIRV QRGISVENSW QIVRRYSDFD
        70         80         90        100        110        120
LLNNSLQIAG LSLPLPPKKL IGNMDREFIA ERQKGLQNYL NVITTNHILS NCELVKKFLD
       130        140        150        160        170        180
PNNYSANYTE IALQQVSMFF RSEPKWEVVE PLKDIGWRIR KKYFLMKIKN QPKERLVLSW
       190        200        210        220        230        240
ADLGPDKYLS DKDFQCLIKL LPSCLHPYIY RVTFATANES SALLIRMFNE KGTLKDLIYK
       250        260        270        280        290        300
AKPKDPFLKK YCNPKKIQGL ELQQIKTYGR QILEVLKFLH DKGFPYGHLH ASNVMLDGDT
       310        320        330        340        350        360
CRLLDLENSL LGLPSFYRSY FSQFRKINTL ESVDVHCFGH LLYEMTYGRP PDSVPVDSFP
       370        380        390        400        410        420
PAPSMAVVAV LESTLSCEAC KNGMPTISRL LQMPLFSDVL LTTSEKPQFK IPTKLKEALR
       430        440        450        460        470        480
IAKECIEKRL IEEQKQIHQH RRLTRAQSHH GSEEERKKRK ILARKKSKRS ALENSEEHSA
       490        500        510        520        530        540
KYSNSNNSAG SGASSPLTSP SSPTPPSTSG ISALPPPPPP PPPPAAPLPP ASTEAPAQLS
       550        560        570
SQAVNGMSRG ALLSSIQNFQ KGTLRKAKTC DHSAPKIG         10         20         30         40         50         60
MAFMEKPPAG KVLLDDTVPL TAAIEASQSL QSHTEYIIRV QRGISVENSW QIVRRYSDFD
        70         80         90        100        110        120
LLNNSLQIAG LSLPLPPKKL IGNMDREFIA ERQKGLQNYL NVITTNHILS NCELVKKFLD
       130        140        150        160        170        180
PNNYSANYTE IALQQVSMFF RSEPKWEVVE PLKDIGWRIR KKYFLMKIKN QPKERLVLSW
       190        200        210        220        230        240
ADLGPDKYLS DKDFQCLIKL LPSCLHPYIY RVTFATANES SALLIRMFNE KGTLKDLIYK
       250        260        270        280        290        300
AKPKDPFLKK YCNPKKIQGL ELQQIKTYGR QILEVLKFLH DKGFPYGHLH ASNVMLDGDT
       310        320        330        340        350        360
CRLLDLENSL LGLPSFYRSY FSQFRKINTL ESVDVHCFGH LLYEMTYGRP PDSVPVDSFP
       370        380        390        400        410        420
PAPSMAVVAV LESTLSCEAC KNGMPTISRL LQMPLFSDVL LTTSEKPQFK IPTKLKEALR
       430        440        450        460        470        480
IAKECIEKRL IEEQKQIHQH RRLTRAQSHH GSEEERKKRK ILARKKSKRS ALENSEEHSA
       490        500        510        520        530        540
KYSNSNNSAG SGASSPLTSP SSPTPPSTSG ISALPPPPPP PPPPAAPLPP ASTEAPAQLS
       550        560        570
SQAVNGMSRG ALLSSIQNFQ KGTLRKAKTC DHSAPKIG         10         20         30         40         50         60
MAFMEKPPAG KVLLDDTVPL TAAIEASQSL QSHTEYIIRV QRGISVENSW QIVRRYSDFD
        70         80         90        100        110        120
LLNNSLQIAG LSLPLPPKKL IGNMDREFIA ERQKGLQNYL NVITTNHILS NCELVKKFLD
       130        140        150        160        170        180
PNNYSANYTE IALQQVSMFF RSEPKWEVVE PLKDIGWRIR KKYFLMKIKN QPKERLVLSW
       190        200        210        220        230        240
ADLGPDKYLS DKDFQCLIKL LPSCLHPYIY RVTFATANES SALLIRMFNE KGTLKDLIYK
       250        260        270        280        290        300
AKPKDPFLKK YCNPKKIQGL ELQQIKTYGR QILEVLKFLH DKGFPYGHLH ASNVMLDGDT
       310        320        330        340        350        360
CRLLDLENSL LGLPSFYRSY FSQFRKINTL ESVDVHCFGH LLYEMTYGRP PDSVPVDSFP
       370        380        390        400        410        420
PAPSMAVVAV LESTLSCEAC KNGMPTISRL LQMPLFSDVL LTTSEKPQFK IPTKLKEALR
       430        440        450        460        470        480
IAKECIEKRL IEEQKQIHQH RRLTRAQSHH GSEEERKKRK ILARKKSKRS ALENSEEHSA
       490        500        510        520        530        540
KYSNSNNSAG SGASSPLTSP SSPTPPSTSG ISALPPPPPP PPPPAAPLPP ASTEAPAQLS
       550        560        570
SQAVNGMSRG ALLSSIQNFQ KGTLRKAKTC DHSAPKIG

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 3 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q7Z7A4-1-unknown	MAFMEK...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q7Z7A4-1-unknown	MAFMEK...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt86718
Q7Z7A4-1-unknown	MAFMEK...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt86720
Q7Z7A4-1-unknown	MAFMEK...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt86722
Q7Z7A4-84-unknown	MDREFI...	84	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt86723
Q7Z7A4-84-unknown	MDREFI...	84	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt106805
Q7Z7A4-84-unknown	MDREFI...	84	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt106806
Q7Z7A4-84-unknown	MDREFI...	84	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt106807
Q7Z7A4-138-unknown	MFFRSE...	138	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt86721
Q7Z7A4-138-unknown	MFFRSE...	138	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000438356
Q7Z7A4-138-unknown	MFFRSE...	138	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt106691
Q7Z7A4-138-unknown	MFFRSE...	138	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt106692
Q7Z7A4-138-unknown	MFFRSE...	138	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt106693
Q7Z7A4-138-unknown	MFFRSE...	138	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt106694
Q7Z7A4-227-unknown	MFNEKG...	227	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt86719
Q7Z7A4-227-unknown	MFNEKG...	227	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt106569
Q7Z7A4-227-unknown	MFNEKG...	227	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt106567
Q7Z7A4-227-unknown	MFNEKG...	227	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt106568
Q7Z7A4-227-unknown	MFNEKG...	227	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt106570
Q7Z7A4-227-unknown	MFNEKG...	227	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt106571
Q7Z7A4-308-unknown	NSLLGL...	308	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000476179
Q7Z7A4-308-unknown	NSLLGL...	308	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt198904
Q7Z7A4-308-unknown	NSLLGL...	308	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt198902
Q7Z7A4-308-unknown	NSLLGL...	308	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt198900
Q7Z7A4-308-unknown	NSLLGL...	308	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt198901
Q7Z7A4-308-unknown	NSLLGL...	308	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt198903
Q7Z7A4-308-unknown	NSLLGL...	308	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt198905
Q7Z7A4-465-unknown	KKSKRS...	465	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000418836
Q7Z7A4-465-unknown	KKSKRS...	465	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt199592
Q7Z7A4-465-unknown	KKSKRS...	465	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt199590
Q7Z7A4-465-unknown	KKSKRS...	465	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt199588
Q7Z7A4-465-unknown	KKSKRS...	465	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt199589
Q7Z7A4-465-unknown	KKSKRS...	465	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt199591
Q7Z7A4-465-unknown	KKSKRS...	465	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt199593

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...FLDPNN	122	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000418831
...FLDPNN	122	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154612
...FLDPNN	122	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154613
...FLDPNN	122	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154614
...FLDPNN	122	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154615
...PSTSGI	510	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000476179
...APKIG	578	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...APKIG	578	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt82337
...APKIG	578	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt82339
...APKIG	578	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt82341
...APKIG	578	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt82340
...APKIG	578	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt82338

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)