Q80W65: Proprotein convertase subtilisin/kexin type 9
| Protein names | - Proprotein convertase subtilisin/kexin type 9 - 3.4.21.- - Neural apoptosis-regulated convertase 1 - NARC-1 - Proprotein convertase 9 - PC9 - Subtilisin/kexin-like protease PC9 |
|---|---|
| Gene names | Pcsk9 |
| Organism | Mus musculus |
| Protease Family | S08.039 |
| Protease ID | S08.039 |
| Chromosome location | |
| UniProt ID | Q80W65 |
3
N-termini
2
C-termini
1
Cleavages
1
Substrates
Sequence
10 20 30 40 50 60
MGTHCSAWLR WPLLPLLPPL LLLLLLLCPT GAGAQDEDGD YEELMLALPS QEDGLADEAA
70 80 90 100 110 120
HVATATFRRC SKEAWRLPGT YIVVLMEETQ RLQIEQTAHR LQTRAARRGY VIKVLHIFYD
130 140 150 160 170 180
LFPGFLVKMS SDLLGLALKL PHVEYIEEDS FVFAQSIPWN LERIIPAWHQ TEEDRSPDGS
190 200 210 220 230 240
SQVEVYLLDT SIQGAHREIE GRVTITDFNS VPEEDGTRFH RQASKCDSHG THLAGVVSGR
250 260 270 280 290 300
DAGVAKGTSL HSLRVLNCQG KGTVSGTLIG LEFIRKSQLI QPSGPLVVLL PLAGGYSRIL
310 320 330 340 350 360
NAACRHLART GVVLVAAAGN FRDDACLYSP ASAPEVITVG ATNAQDQPVT LGTLGTNFGR
370 380 390 400 410 420
CVDLFAPGKD IIGASSDCST CFMSQSGTSQ AAAHVAGIVA RMLSREPTLT LAELRQRLIH
430 440 450 460 470 480
FSTKDVINMA WFPEDQQVLT PNLVATLPPS THETGGQLLC RTVWSAHSGP TRTATATARC
490 500 510 520 530 540
APEEELLSCS SFSRSGRRRG DWIEAIGGQQ VCKALNAFGG EGVYAVARCC LVPRANCSIH
550 560 570 580 590 600
NTPAARAGLE THVHCHQKDH VLTGCSFHWE VEDLSVRRQP ALRSRRQPGQ CVGHQAASVY
610 620 630 640 650 660
ASCCHAPGLE CKIKEHGISG PSEQVTVACE AGWTLTGCNV LPGASLTLGA YSVDNLCVAR
670 680 690
VHDTARADRT SGEATVAAAI CCRSRPSAKA SWVQ
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
3 N-termini - 2 C-termini - 1 Cleavages - 1 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| Q80W65-35-unknown | QDEDGD... | 35 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| Q80W65-87-unknown | EETQRL... | 87 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC34773 | |||
| Q80W65-156-unknown | SIPWNL... | 156 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...IVVLME | 86 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC34773 | |||
| ...ASWVQ | 694 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| PCSK9_MOUSE | 86 | VLME.|.EETQ | inferred from experiment | unknown | MEROPS | Chretien M | Seidah NG et al.:The secretory proprotein conver... (S08.039) | 12552133, |
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| PCSK9_MOUSE | 86 | VLME.|.EETQ | inferred from experiment | unknown | MEROPS | Chretien M | Seidah NG et al.:The secretory proprotein conver... (S08.039) | 12552133, |