TopFIND 4.0

Q80WE1: Synaptic functional regulator FMR1 {ECO:0000305}

General Information

Protein names
- Synaptic functional regulator FMR1 {ECO:0000305}
- Fragile X mental retardation protein 1 homolog {ECO:0000312|RGD:2623}
- FMRP {ECO:0000303|Ref.1}
- Protein FMR-1 {ECO:0000250|UniProtKB:Q06787}
Gene names Fmr1
Organism Rattus norvegicus
Protease Family
Protease ID
Chromosome location
UniProt ID Q80WE1

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MEELVVEVRG SNGAFYKAFV KDVHEDSITV AFENNWQPER QIPFHDVRFP PPVGYNKDIN 
        70         80         90        100        110        120 
ESDEVEVYSR ANEKEPCCWW LAKVRMIKGE FYVIEYAACD ATYNEIVTIE RLRSVNPNKP 
       130        140        150        160        170        180 
ATKDTFHKIK LEVPEDLRQM CAKESAHKDF KKAVGAFSVT YDPENYQLVI LSINEVTSKR 
       190        200        210        220        230        240 
AHMLIDMHFR SLRTKLSLIL RNEEASKQLE SSRQLASRFH EQFIVREDLM GLAIGTHGAN 
       250        260        270        280        290        300 
IQQARKVPGV TAIDLDEDTC TFHIYGEDQD AVKKARSFLE FAEDVIQVPR NLVGKVIGKN 
       310        320        330        340        350        360 
GKLIQEIVDK SGVVRVRIEA ENEKSVPQEE ENLPPSSLPS NNSRVGSNSS EEKKHLDTKE 
       370        380        390        400        410        420 
NTHFSQPNST KVQRGMVPFV FVGTKDSIAN ATVLLDYHLN YLKEVDQLRL ERLQIDEQLR 
       430        440        450        460        470        480 
QIGASSRPPP NRTDKEKGYV TDDGQGMGRG SRPYRNRGHG RRGPGYTSGT NSEASNASET 
       490        500        510        520        530        540 
ESDHRDELSD WSLAPTEEER ESFLRRGDGR RRGGGGRGQG GRGRGGGFKG NDDHSRTDNR 
       550        560        570        580        590    
PRNPRETKGR TTDGSLQSTS SEGSRLRTGK DRNQKKEKPD SVDGLQPLVN GVP

Isoforms

- Isoform 2 of Fragile X mental retardation protein 1 homolog - Isoform 2 of Synaptic functional regulator FMR1

Sequence View

        10         20         30         40         50         60 
MEELVVEVRG SNGAFYKAFV KDVHEDSITV AFENNWQPER QIPFHDVRFP PPVGYNKDIN 
        70         80         90        100        110        120 
ESDEVEVYSR ANEKEPCCWW LAKVRMIKGE FYVIEYAACD ATYNEIVTIE RLRSVNPNKP 
       130        140        150        160        170        180 
ATKDTFHKIK LEVPEDLRQM CAKESAHKDF KKAVGAFSVT YDPENYQLVI LSINEVTSKR 
       190        200        210        220        230        240 
AHMLIDMHFR SLRTKLSLIL RNEEASKQLE SSRQLASRFH EQFIVREDLM GLAIGTHGAN 
       250        260        270        280        290        300 
IQQARKVPGV TAIDLDEDTC TFHIYGEDQD AVKKARSFLE FAEDVIQVPR NLVGKVIGKN 
       310        320        330        340        350        360 
GKLIQEIVDK SGVVRVRIEA ENEKSVPQEE ENLPPSSLPS NNSRVGSNSS EEKKHLDTKE 
       370        380        390        400        410        420 
NTHFSQPNST KVQRGMVPFV FVGTKDSIAN ATVLLDYHLN YLKEVDQLRL ERLQIDEQLR 
       430        440        450        460        470        480 
QIGASSRPPP NRTDKEKGYV TDDGQGMGRG SRPYRNRGHG RRGPGYTSGT NSEASNASET 
       490        500        510        520        530        540 
ESDHRDELSD WSLAPTEEER ESFLRRGDGR RRGGGGRGQG GRGRGGGFKG NDDHSRTDNR 
       550        560        570        580        590    
PRNPRETKGR TTDGSLQSTS SEGSRLRTGK DRNQKKEKPD SVDGLQPLVN GVP         10         20         30         40         50         60 
MEELVVEVRG SNGAFYKAFV KDVHEDSITV AFENNWQPER QIPFHDVRFP PPVGYNKDIN 
        70         80         90        100        110        120 
ESDEVEVYSR ANEKEPCCWW LAKVRMIKGE FYVIEYAACD ATYNEIVTIE RLRSVNPNKP 
       130        140        150        160        170        180 
ATKDTFHKIK LEVPEDLRQM CAKESAHKDF KKAVGAFSVT YDPENYQLVI LSINEVTSKR 
       190        200        210        220        230        240 
AHMLIDMHFR SLRTKLSLIL RNEEASKQLE SSRQLASRFH EQFIVREDLM GLAIGTHGAN 
       250        260        270        280        290        300 
IQQARKVPGV TAIDLDEDTC TFHIYGEDQD AVKKARSFLE FAEDVIQVPR NLVGKVIGKN 
       310        320        330        340        350        360 
GKLIQEIVDK SGVVRVRIEA ENEKSVPQEE ENLPPSSLPS NNSRVGSNSS EEKKHLDTKE 
       370        380        390        400        410        420 
NTHFSQPNST KVQRGMVPFV FVGTKDSIAN ATVLLDYHLN YLKEVDQLRL ERLQIDEQLR 
       430        440        450        460        470        480 
QIGASSRPPP NRTDKEKGYV TDDGQGMGRG SRPYRNRGHG RRGPGYTSGT NSEASNASET 
       490        500        510        520        530        540 
ESDHRDELSD WSLAPTEEER ESFLRRGDGR RRGGGGRGQG GRGRGGGFKG NDDHSRTDNR 
       550        560        570        580        590    
PRNPRETKGR TTDGSLQSTS SEGSRLRTGK DRNQKKEKPD SVDGLQPLVN GVP



Filter Information:


(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q80WE1-1-Acetylation MEELVV... 1 acetylation- inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q80WE1-1-Acetylation MEELVV... 1 acetylation- inferred from isoform by sequence similarity unknown TopFIND inferred from TNt194228
    Q80WE1-1-unknown MEELVV... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt192652

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...VNGVP 593 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...VNGVP 593 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt152598

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)