Q80X41: Serine/threonine-protein kinase VRK1
Protein names | - Serine/threonine-protein kinase VRK1 - 2.7.11.1 - Serine/threonine-protein kinase 51PK - Vaccinia-related kinase 1 |
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Gene names | Vrk1 |
Organism | Mus musculus |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q80X41 |
3
N-termini
3
C-termini
2
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MPRVKAAQAG RPGPAKRRLA EQFAAGEVLT DMSRKEWKLG LPIGQGGFGC IYLADTNSSK
70 80 90 100 110 120
PVGSDAPCVV KVEPSDNGPL FTELKFYQRA AKPEQIQKWI RTHKLKYLGV PKYWGSGLHD
130 140 150 160 170 180
KNGKSYRFMI MDRFGSDLQK IYEANAKRFS RKTVLQLSLR ILDILEYIHE HEYVHGDIKA
190 200 210 220 230 240
SNLLLSHKNP DQVYLVDYGL AYRYCPDGVH KEYKEDPKRC HDGTLEFTSI DAHKGVAPSR
250 260 270 280 290 300
RGDLEILGYC MIQWLSGCLP WEDNLKDPNY VRDSKIRYRD NVAALMEKCF PEKNKPGEIA
310 320 330 340 350 360
KYMESVKLLE YTEKPLYQNL RDILLQGLKA IGSKDDGKLD FSAVENGSVK TRPASKKRKK
370 380 390 400 410 420
EAEESAVCAV EDMECSDTQV QEAAQTRSVE SQGAIHGSMS QPAAGCSSSD SSRRQQHLGL
430 440
EQDMLRLDRR GSRTRKKAQK
Isoforms
- Isoform 2 of Serine/threonine-protein kinase VRK1 - Isoform 3 of Serine/threonine-protein kinase VRK1 - Isoform 5 of Serine/threonine-protein kinase VRK1Sequence View
10 20 30 40 50 60
MPRVKAAQAG RPGPAKRRLA EQFAAGEVLT DMSRKEWKLG LPIGQGGFGC IYLADTNSSK
70 80 90 100 110 120
PVGSDAPCVV KVEPSDNGPL FTELKFYQRA AKPEQIQKWI RTHKLKYLGV PKYWGSGLHD
130 140 150 160 170 180
KNGKSYRFMI MDRFGSDLQK IYEANAKRFS RKTVLQLSLR ILDILEYIHE HEYVHGDIKA
190 200 210 220 230 240
SNLLLSHKNP DQVYLVDYGL AYRYCPDGVH KEYKEDPKRC HDGTLEFTSI DAHKGVAPSR
250 260 270 280 290 300
RGDLEILGYC MIQWLSGCLP WEDNLKDPNY VRDSKIRYRD NVAALMEKCF PEKNKPGEIA
310 320 330 340 350 360
KYMESVKLLE YTEKPLYQNL RDILLQGLKA IGSKDDGKLD FSAVENGSVK TRPASKKRKK
370 380 390 400 410 420
EAEESAVCAV EDMECSDTQV QEAAQTRSVE SQGAIHGSMS QPAAGCSSSD SSRRQQHLGL
430 440
EQDMLRLDRR GSRTRKKAQK
10 20 30 40 50 60
MPRVKAAQAG RPGPAKRRLA EQFAAGEVLT DMSRKEWKLG LPIGQGGFGC IYLADTNSSK
70 80 90 100 110 120
PVGSDAPCVV KVEPSDNGPL FTELKFYQRA AKPEQIQKWI RTHKLKYLGV PKYWGSGLHD
130 140 150 160 170 180
KNGKSYRFMI MDRFGSDLQK IYEANAKRFS RKTVLQLSLR ILDILEYIHE HEYVHGDIKA
190 200 210 220 230 240
SNLLLSHKNP DQVYLVDYGL AYRYCPDGVH KEYKEDPKRC HDGTLEFTSI DAHKGVAPSR
250 260 270 280 290 300
RGDLEILGYC MIQWLSGCLP WEDNLKDPNY VRDSKIRYRD NVAALMEKCF PEKNKPGEIA
310 320 330 340 350 360
KYMESVKLLE YTEKPLYQNL RDILLQGLKA IGSKDDGKLD FSAVENGSVK TRPASKKRKK
370 380 390 400 410 420
EAEESAVCAV EDMECSDTQV QEAAQTRSVE SQGAIHGSMS QPAAGCSSSD SSRRQQHLGL
430 440
EQDMLRLDRR GSRTRKKAQK
10 20 30 40 50 60
MPRVKAAQAG RPGPAKRRLA EQFAAGEVLT DMSRKEWKLG LPIGQGGFGC IYLADTNSSK
70 80 90 100 110 120
PVGSDAPCVV KVEPSDNGPL FTELKFYQRA AKPEQIQKWI RTHKLKYLGV PKYWGSGLHD
130 140 150 160 170 180
KNGKSYRFMI MDRFGSDLQK IYEANAKRFS RKTVLQLSLR ILDILEYIHE HEYVHGDIKA
190 200 210 220 230 240
SNLLLSHKNP DQVYLVDYGL AYRYCPDGVH KEYKEDPKRC HDGTLEFTSI DAHKGVAPSR
250 260 270 280 290 300
RGDLEILGYC MIQWLSGCLP WEDNLKDPNY VRDSKIRYRD NVAALMEKCF PEKNKPGEIA
310 320 330 340 350 360
KYMESVKLLE YTEKPLYQNL RDILLQGLKA IGSKDDGKLD FSAVENGSVK TRPASKKRKK
370 380 390 400 410 420
EAEESAVCAV EDMECSDTQV QEAAQTRSVE SQGAIHGSMS QPAAGCSSSD SSRRQQHLGL
430 440
EQDMLRLDRR GSRTRKKAQK
Protein Neighborhood
Domains & Features
3 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q80X41-1-unknown | MPRVKA... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q80X41-1-unknown | MPRVKA... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt94295 | |||
Q80X41-1-unknown | MPRVKA... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt94296 | |||
Q80X41-1-unknown | MPRVKA... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt94297 | |||
Q80X41-24-unknown | AAGEVL... | 24 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC30697 | |||
Q80X41-24-unknown | AAGEVL... | 24 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt137152 | |||
Q80X41-24-unknown | AAGEVL... | 24 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt137154 | |||
Q80X41-24-unknown | AAGEVL... | 24 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt137155 | |||
Q80X41-374-unknown | ECSDTQ... | 374 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC30701 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...LAEQFA | 23 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC30697 | |||
...LAEQFA | 23 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt120045 | |||
...LAEQFA | 23 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt120047 | |||
...LAEQFA | 23 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt120048 | |||
...AVEDME | 373 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC30701 | |||
...AVEDME | 373 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt134855 | |||
...AVEDME | 373 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt134900 | |||
...AVEDME | 373 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt134901 | |||
...KKAQK | 440 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...KKAQK | 440 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt89915 | |||
...KKAQK | 440 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt89914 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
CATE_MOUSE | 23 | EQFA.|.AAGE | inferred from experiment | unknown | MEROPS | Merops CATE_MOUSE -> VRK1_MOUSE @23 | ||
CATE_MOUSE | 373 | EDME.|.ECSD | inferred from experiment | unknown | MEROPS | Merops CATE_MOUSE -> VRK1_MOUSE @373 |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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