TopFIND 4.0

Q86T96: E3 ubiquitin-protein ligase RNF180

General Information

Protein names
- E3 ubiquitin-protein ligase RNF180
- 2.3.2.27
- RING finger protein 180
- RING-type E3 ubiquitin transferase RNF180 {ECO:0000305}
Gene names RNF180
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q86T96

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MKRSKELITK NHSQEETSIL RCWKCRKCIA SSGCFMEYLE NQVIKDKDDS VDAQNICHVW 
        70         80         90        100        110        120 
HMNVEALPEW ISCLIQKAQW TVGKLNCPFC GARLGGFNFV STPKCSCGQL AAVHLSKSRT 
       130        140        150        160        170        180 
DYQPTQAGRL MRPSVKYLSH PRVQSGCDKE ALLTGGGSEN RNHRLLNMAR NNNDPGRLTE 
       190        200        210        220        230        240 
ALCLEVRPTY FEMKNEKLLS KASEPKYQLF VPQLVTGRCA TRAFHRKSHS LDLNISEKLT 
       250        260        270        280        290        300 
LLPTLYEIHS KTTAYSRLNE TQPIDLSGLP LQSSKNSYSF QNPSSFDPSM LLQRFSVAPH 
       310        320        330        340        350        360 
ETQTQRGGEF QCGLEAASVY SDHTNTNNLT FLMDLPSAGR SMPEASDQEE HLSPLDFLHS 
       370        380        390        400        410        420 
ANFSLGSINQ RLNKRERSKL KNLRRKQRRR ERWLQKQGKY SGVGLLDHMT LNNEMSTDED 
       430        440        450        460        470        480 
NEYAEEKDSY ICAVCLDVYF NPYMCYPCHH IFCEPCLRTL AKDNPSSTPC PLCRTIISRV 
       490        500        510        520        530        540 
FFQTELNNAT KTFFTKEYLK IKQSFQKSNS AKWPLPSCRK AFHLFGGFRR HAAPVTRRQF 
       550        560        570        580        590    
PHGAHRMDYL HFEDDSRGWW FDMDMVIIYI YSVNWVIGFI VFCFLCYFFF PF

Isoforms

- Isoform 2 of E3 ubiquitin-protein ligase RNF180 - Isoform 3 of E3 ubiquitin-protein ligase RNF180

Sequence View

        10         20         30         40         50         60 
MKRSKELITK NHSQEETSIL RCWKCRKCIA SSGCFMEYLE NQVIKDKDDS VDAQNICHVW 
        70         80         90        100        110        120 
HMNVEALPEW ISCLIQKAQW TVGKLNCPFC GARLGGFNFV STPKCSCGQL AAVHLSKSRT 
       130        140        150        160        170        180 
DYQPTQAGRL MRPSVKYLSH PRVQSGCDKE ALLTGGGSEN RNHRLLNMAR NNNDPGRLTE 
       190        200        210        220        230        240 
ALCLEVRPTY FEMKNEKLLS KASEPKYQLF VPQLVTGRCA TRAFHRKSHS LDLNISEKLT 
       250        260        270        280        290        300 
LLPTLYEIHS KTTAYSRLNE TQPIDLSGLP LQSSKNSYSF QNPSSFDPSM LLQRFSVAPH 
       310        320        330        340        350        360 
ETQTQRGGEF QCGLEAASVY SDHTNTNNLT FLMDLPSAGR SMPEASDQEE HLSPLDFLHS 
       370        380        390        400        410        420 
ANFSLGSINQ RLNKRERSKL KNLRRKQRRR ERWLQKQGKY SGVGLLDHMT LNNEMSTDED 
       430        440        450        460        470        480 
NEYAEEKDSY ICAVCLDVYF NPYMCYPCHH IFCEPCLRTL AKDNPSSTPC PLCRTIISRV 
       490        500        510        520        530        540 
FFQTELNNAT KTFFTKEYLK IKQSFQKSNS AKWPLPSCRK AFHLFGGFRR HAAPVTRRQF 
       550        560        570        580        590    
PHGAHRMDYL HFEDDSRGWW FDMDMVIIYI YSVNWVIGFI VFCFLCYFFF PF         10         20         30         40         50         60 
MKRSKELITK NHSQEETSIL RCWKCRKCIA SSGCFMEYLE NQVIKDKDDS VDAQNICHVW 
        70         80         90        100        110        120 
HMNVEALPEW ISCLIQKAQW TVGKLNCPFC GARLGGFNFV STPKCSCGQL AAVHLSKSRT 
       130        140        150        160        170        180 
DYQPTQAGRL MRPSVKYLSH PRVQSGCDKE ALLTGGGSEN RNHRLLNMAR NNNDPGRLTE 
       190        200        210        220        230        240 
ALCLEVRPTY FEMKNEKLLS KASEPKYQLF VPQLVTGRCA TRAFHRKSHS LDLNISEKLT 
       250        260        270        280        290        300 
LLPTLYEIHS KTTAYSRLNE TQPIDLSGLP LQSSKNSYSF QNPSSFDPSM LLQRFSVAPH 
       310        320        330        340        350        360 
ETQTQRGGEF QCGLEAASVY SDHTNTNNLT FLMDLPSAGR SMPEASDQEE HLSPLDFLHS 
       370        380        390        400        410        420 
ANFSLGSINQ RLNKRERSKL KNLRRKQRRR ERWLQKQGKY SGVGLLDHMT LNNEMSTDED 
       430        440        450        460        470        480 
NEYAEEKDSY ICAVCLDVYF NPYMCYPCHH IFCEPCLRTL AKDNPSSTPC PLCRTIISRV 
       490        500        510        520        530        540 
FFQTELNNAT KTFFTKEYLK IKQSFQKSNS AKWPLPSCRK AFHLFGGFRR HAAPVTRRQF 
       550        560        570        580        590    
PHGAHRMDYL HFEDDSRGWW FDMDMVIIYI YSVNWVIGFI VFCFLCYFFF PF



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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q86T96-1-unknown MKRSKE... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q86T96-1-unknown MKRSKE... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt87925
    Q86T96-1-unknown MKRSKE... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt87926

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...FFFPF 592 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)