Q86TL0: Cysteine protease ATG4D

General Information

Protein names	- Cysteine protease ATG4D - 3.4.22.- - AUT-like 4 cysteine endopeptidase - Autophagin-4 - Autophagy-related cysteine endopeptidase 4 - Autophagy-related protein 4 homolog D - Cysteine protease ATG4D, mitochondrial
Gene names	ATG4D
Organism	Homo sapiens
Protease Family	C54.005
Protease ID	C54.005
Chromosome location
UniProt ID	Q86TL0

7 N-termini

3 C-termini

0 Cleavages

2 Substrates

Sequence

        10         20         30         40         50         60
MNSVSPAAAQ YRSSSPEDAR RRPEARRPRG PRGPDPNGLG PSGASGPALG SPGAGPSEPD
        70         80         90        100        110        120
EVDKFKAKFL TAWNNVKYGW VVKSRTSFSK ISSIHLCGRR YRFEGEGDIQ RFQRDFVSRL
       130        140        150        160        170        180
WLTYRRDFPP LPGGCLTSDC GWGCMLRSGQ MMLAQGLLLH FLPRDWTWAE GMGLGPPELS
       190        200        210        220        230        240
GSASPSRYHG PARWMPPRWA QGAPELEQER RHRQIVSWFA DHPRAPFGLH RLVELGQSSG
       250        260        270        280        290        300
KKAGDWYGPS LVAHILRKAV ESCSDVTRLV VYVSQDCTVY KADVARLVAR PDPTAEWKSV
       310        320        330        340        350        360
VILVPVRLGG ETLNPVYVPC VKELLRCELC LGIMGGKPRH SLYFIGYQDD FLLYLDPHYC
       370        380        390        400        410        420
QPTVDVSQAD FPLESFHCTS PRKMAFAKMD PSCTVGFYAG DRKEFETLCS ELTRVLSSSS
       430        440        450        460        470
ATERYPMFTL AEGHAQDHSL DDLCSQLAQP TLRLPRTGRL LRAKRPSSED FVFL

Isoforms

- Isoform 2 of Cysteine protease ATG4D

Sequence View

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Protein Neighborhood

Domains & Features

7 N-termini - 3 C-termini - 0 Cleavages - 2 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q86TL0-1-unknown	MNSVSP...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q86TL0-1-acetylation	MNSVSP...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q86TL0-64-unknown	KFKAKF...	64		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q86TL0-65-unknown	FKAKFL...	65		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000467223
Q86TL0-321-unknown	VKELLR...	321		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000466759
Q86TL0-334-unknown	MGGKPR...	334		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000441375
Q86TL0-336-unknown	GKPRHS...	336		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000467694

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SGKKAG	243	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000467223
...DFPLES	374	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000468780
...DFVFL	474	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GBRL2_HUMAN	116	TFGF.\|.F	inferred from experiment	unknown	MEROPS	Yin XM	Li M et al.:Kinetics comparisons of mammali... (C54.002)	21177865,
MLP3B_HUMAN	120	TFGM.\|.MKLS	inferred from experiment	unknown	MEROPS	Yin XM	Li M et al.:Kinetics comparisons of mammali... (C54.002)	21177865,