Q86TM6: E3 ubiquitin-protein ligase synoviolin

General Information

Protein names	- E3 ubiquitin-protein ligase synoviolin - 2.3.2.27 - RING-type E3 ubiquitin transferase synoviolin {ECO:0000305} - Synovial apoptosis inhibitor 1
Gene names	SYVN1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q86TM6

4 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of E3 ubiquitin-protein ligase synoviolin - Isoform 3 of E3 ubiquitin-protein ligase synoviolin

Sequence View

        10         20         30         40         50         60
MFRTAVMMAA SLALTGAVVA HAYYLKHQFY PTVVYLTKSS PSMAVLYIQA FVLVFLLGKV
        70         80         90        100        110        120
MGKVFFGQLR AAEMEHLLER SWYAVTETCL AFTVFRDDFS PRFVALFTLL LFLKCFHWLA
       130        140        150        160        170        180
EDRVDFMERS PNISWLFHCR IVSLMFLLGI LDFLFVSHAY HSILTRGASV QLVFGFEYAI
       190        200        210        220        230        240
LMTMVLTIFI KYVLHSVDLQ SENPWDNKAV YMLYTELFTG FIKVLLYMAF MTIMIKVHTF
       250        260        270        280        290        300
PLFAIRPMYL AMRQFKKAVT DAIMSRRAIR NMNTLYPDAT PEELQAMDNV CIICREEMVT
       310        320        330        340        350        360
GAKRLPCNHI FHTSCLRSWF QRQQTCPTCR MDVLRASLPA QSPPPPEPAD QGPPPAPHPP
       370        380        390        400        410        420
PLLPQPPNFP QGLLPPFPPG MFPLWPPMGP FPPVPPPPSS GEAVAPPSTS AAALSRPSGA
       430        440        450        460        470        480
ATTTAAGTSA TAASATASGP GSGSAPEAGP APGFPFPPPW MGMPLPPPFA FPPMPVPPAG
       490        500        510        520        530        540
FAGLTPEELR ALEGHERQHL EARLQSLRNI HTLLDAAMLQ INQYLTVLAS LGPPRPATSV
       550        560        570        580        590        600
NSTEETATTV VAAASSTSIP SSEATTPTPG ASPPAPEMER PPAPESVGTE EMPEDGEPDA
       610
AELRRRRLQK LESPVAH         10         20         30         40         50         60
MFRTAVMMAA SLALTGAVVA HAYYLKHQFY PTVVYLTKSS PSMAVLYIQA FVLVFLLGKV
        70         80         90        100        110        120
MGKVFFGQLR AAEMEHLLER SWYAVTETCL AFTVFRDDFS PRFVALFTLL LFLKCFHWLA
       130        140        150        160        170        180
EDRVDFMERS PNISWLFHCR IVSLMFLLGI LDFLFVSHAY HSILTRGASV QLVFGFEYAI
       190        200        210        220        230        240
LMTMVLTIFI KYVLHSVDLQ SENPWDNKAV YMLYTELFTG FIKVLLYMAF MTIMIKVHTF
       250        260        270        280        290        300
PLFAIRPMYL AMRQFKKAVT DAIMSRRAIR NMNTLYPDAT PEELQAMDNV CIICREEMVT
       310        320        330        340        350        360
GAKRLPCNHI FHTSCLRSWF QRQQTCPTCR MDVLRASLPA QSPPPPEPAD QGPPPAPHPP
       370        380        390        400        410        420
PLLPQPPNFP QGLLPPFPPG MFPLWPPMGP FPPVPPPPSS GEAVAPPSTS AAALSRPSGA
       430        440        450        460        470        480
ATTTAAGTSA TAASATASGP GSGSAPEAGP APGFPFPPPW MGMPLPPPFA FPPMPVPPAG
       490        500        510        520        530        540
FAGLTPEELR ALEGHERQHL EARLQSLRNI HTLLDAAMLQ INQYLTVLAS LGPPRPATSV
       550        560        570        580        590        600
NSTEETATTV VAAASSTSIP SSEATTPTPG ASPPAPEMER PPAPESVGTE EMPEDGEPDA
       610
AELRRRRLQK LESPVAH

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q86TM6-1-unknown	MFRTAV...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt91324
Q86TM6-1-unknown	MFRTAV...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt91325
Q86TM6-23-unknown	YYLKHQ...	23	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q86TM6-23-unknown	YYLKHQ...	23	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt113226
Q86TM6-23-unknown	YYLKHQ...	23	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt113227
Q86TM6-558-unknown	SIPSSE...	558	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176050
Q86TM6-558-unknown	SIPSSE...	558	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176049
Q86TM6-558-	SIPSSE...	558		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SPVAH	617	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SPVAH	617	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt86942
...SPVAH	617	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt86943

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)