TopFIND 4.0

Q86TU7: Actin-histidine N-methyltransferase {ECO:0000305}

General Information

Protein names
- Actin-histidine N-methyltransferase {ECO:0000305}
- 2.1.1.85 {ECO:0000269|PubMed:30526847, ECO:0000269|PubMed:30626964}
- SET domain-containing protein 3 {ECO:0000305}
- hSETD3 {ECO:0000303|PubMed:28442573}
Gene names SETD3
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q86TU7

1

N-termini

2

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MGKKSRVKTQ KSGTGATATV SPKEILNLTS ELLQKCSSPA PGPGKEWEEY VQIRTLVEKI 
        70         80         90        100        110        120 
RKKQKGLSVT FDGKREDYFP DLMKWASENG ASVEGFEMVN FKEEGFGLRA TRDIKAEELF 
       130        140        150        160        170        180 
LWVPRKLLMT VESAKNSVLG PLYSQDRILQ AMGNIALAFH LLCERASPNS FWQPYIQTLP 
       190        200        210        220        230        240 
SEYDTPLYFE EDEVRYLQST QAIHDVFSQY KNTARQYAYF YKVIQTHPHA NKLPLKDSFT 
       250        260        270        280        290        300 
YEDYRWAVSS VMTRQNQIPT EDGSRVTLAL IPLWDMCNHT NGLITTGYNL EDDRCECVAL 
       310        320        330        340        350        360 
QDFRAGEQIY IFYGTRSNAE FVIHSGFFFD NNSHDRVKIK LGVSKSDRLY AMKAEVLARA 
       370        380        390        400        410        420 
GIPTSSVFAL HFTEPPISAQ LLAFLRVFCM TEEELKEHLL GDSAIDRIFT LGNSEFPVSW 
       430        440        450        460        470        480 
DNEVKLWTFL EDRASLLLKT YKTTIEEDKS VLKNHDLSVR AKMAIKLRLG EKEILEKAVK 
       490        500        510        520        530        540 
SAAVNREYYR QQMEEKAPLP KYEESNLGLL ESSVGDSRLP LVLRNLEEEA GVQDALNIRE 
       550        560        570        580        590    
AISKAKATEN GLVNGENSIP NGTRSENESL NQESKRAVED AKGSSSDSTA GVKE

Isoforms

- Isoform 2 of Histone-lysine N-methyltransferase setd3 - Isoform 3 of Histone-lysine N-methyltransferase setd3 - Isoform 2 of Actin-histidine N-methyltransferase - Isoform 3 of Actin-histidine N-methyltransferase

Sequence View

        10         20         30         40         50         60 
MGKKSRVKTQ KSGTGATATV SPKEILNLTS ELLQKCSSPA PGPGKEWEEY VQIRTLVEKI 
        70         80         90        100        110        120 
RKKQKGLSVT FDGKREDYFP DLMKWASENG ASVEGFEMVN FKEEGFGLRA TRDIKAEELF 
       130        140        150        160        170        180 
LWVPRKLLMT VESAKNSVLG PLYSQDRILQ AMGNIALAFH LLCERASPNS FWQPYIQTLP 
       190        200        210        220        230        240 
SEYDTPLYFE EDEVRYLQST QAIHDVFSQY KNTARQYAYF YKVIQTHPHA NKLPLKDSFT 
       250        260        270        280        290        300 
YEDYRWAVSS VMTRQNQIPT EDGSRVTLAL IPLWDMCNHT NGLITTGYNL EDDRCECVAL 
       310        320        330        340        350        360 
QDFRAGEQIY IFYGTRSNAE FVIHSGFFFD NNSHDRVKIK LGVSKSDRLY AMKAEVLARA 
       370        380        390        400        410        420 
GIPTSSVFAL HFTEPPISAQ LLAFLRVFCM TEEELKEHLL GDSAIDRIFT LGNSEFPVSW 
       430        440        450        460        470        480 
DNEVKLWTFL EDRASLLLKT YKTTIEEDKS VLKNHDLSVR AKMAIKLRLG EKEILEKAVK 
       490        500        510        520        530        540 
SAAVNREYYR QQMEEKAPLP KYEESNLGLL ESSVGDSRLP LVLRNLEEEA GVQDALNIRE 
       550        560        570        580        590    
AISKAKATEN GLVNGENSIP NGTRSENESL NQESKRAVED AKGSSSDSTA GVKE         10         20         30         40         50         60 
MGKKSRVKTQ KSGTGATATV SPKEILNLTS ELLQKCSSPA PGPGKEWEEY VQIRTLVEKI 
        70         80         90        100        110        120 
RKKQKGLSVT FDGKREDYFP DLMKWASENG ASVEGFEMVN FKEEGFGLRA TRDIKAEELF 
       130        140        150        160        170        180 
LWVPRKLLMT VESAKNSVLG PLYSQDRILQ AMGNIALAFH LLCERASPNS FWQPYIQTLP 
       190        200        210        220        230        240 
SEYDTPLYFE EDEVRYLQST QAIHDVFSQY KNTARQYAYF YKVIQTHPHA NKLPLKDSFT 
       250        260        270        280        290        300 
YEDYRWAVSS VMTRQNQIPT EDGSRVTLAL IPLWDMCNHT NGLITTGYNL EDDRCECVAL 
       310        320        330        340        350        360 
QDFRAGEQIY IFYGTRSNAE FVIHSGFFFD NNSHDRVKIK LGVSKSDRLY AMKAEVLARA 
       370        380        390        400        410        420 
GIPTSSVFAL HFTEPPISAQ LLAFLRVFCM TEEELKEHLL GDSAIDRIFT LGNSEFPVSW 
       430        440        450        460        470        480 
DNEVKLWTFL EDRASLLLKT YKTTIEEDKS VLKNHDLSVR AKMAIKLRLG EKEILEKAVK 
       490        500        510        520        530        540 
SAAVNREYYR QQMEEKAPLP KYEESNLGLL ESSVGDSRLP LVLRNLEEEA GVQDALNIRE 
       550        560        570        580        590    
AISKAKATEN GLVNGENSIP NGTRSENESL NQESKRAVED AKGSSSDSTA GVKE         10         20         30         40         50         60 
MGKKSRVKTQ KSGTGATATV SPKEILNLTS ELLQKCSSPA PGPGKEWEEY VQIRTLVEKI 
        70         80         90        100        110        120 
RKKQKGLSVT FDGKREDYFP DLMKWASENG ASVEGFEMVN FKEEGFGLRA TRDIKAEELF 
       130        140        150        160        170        180 
LWVPRKLLMT VESAKNSVLG PLYSQDRILQ AMGNIALAFH LLCERASPNS FWQPYIQTLP 
       190        200        210        220        230        240 
SEYDTPLYFE EDEVRYLQST QAIHDVFSQY KNTARQYAYF YKVIQTHPHA NKLPLKDSFT 
       250        260        270        280        290        300 
YEDYRWAVSS VMTRQNQIPT EDGSRVTLAL IPLWDMCNHT NGLITTGYNL EDDRCECVAL 
       310        320        330        340        350        360 
QDFRAGEQIY IFYGTRSNAE FVIHSGFFFD NNSHDRVKIK LGVSKSDRLY AMKAEVLARA 
       370        380        390        400        410        420 
GIPTSSVFAL HFTEPPISAQ LLAFLRVFCM TEEELKEHLL GDSAIDRIFT LGNSEFPVSW 
       430        440        450        460        470        480 
DNEVKLWTFL EDRASLLLKT YKTTIEEDKS VLKNHDLSVR AKMAIKLRLG EKEILEKAVK 
       490        500        510        520        530        540 
SAAVNREYYR QQMEEKAPLP KYEESNLGLL ESSVGDSRLP LVLRNLEEEA GVQDALNIRE 
       550        560        570        580        590    
AISKAKATEN GLVNGENSIP NGTRSENESL NQESKRAVED AKGSSSDSTA GVKE         10         20         30         40         50         60 
MGKKSRVKTQ KSGTGATATV SPKEILNLTS ELLQKCSSPA PGPGKEWEEY VQIRTLVEKI 
        70         80         90        100        110        120 
RKKQKGLSVT FDGKREDYFP DLMKWASENG ASVEGFEMVN FKEEGFGLRA TRDIKAEELF 
       130        140        150        160        170        180 
LWVPRKLLMT VESAKNSVLG PLYSQDRILQ AMGNIALAFH LLCERASPNS FWQPYIQTLP 
       190        200        210        220        230        240 
SEYDTPLYFE EDEVRYLQST QAIHDVFSQY KNTARQYAYF YKVIQTHPHA NKLPLKDSFT 
       250        260        270        280        290        300 
YEDYRWAVSS VMTRQNQIPT EDGSRVTLAL IPLWDMCNHT NGLITTGYNL EDDRCECVAL 
       310        320        330        340        350        360 
QDFRAGEQIY IFYGTRSNAE FVIHSGFFFD NNSHDRVKIK LGVSKSDRLY AMKAEVLARA 
       370        380        390        400        410        420 
GIPTSSVFAL HFTEPPISAQ LLAFLRVFCM TEEELKEHLL GDSAIDRIFT LGNSEFPVSW 
       430        440        450        460        470        480 
DNEVKLWTFL EDRASLLLKT YKTTIEEDKS VLKNHDLSVR AKMAIKLRLG EKEILEKAVK 
       490        500        510        520        530        540 
SAAVNREYYR QQMEEKAPLP KYEESNLGLL ESSVGDSRLP LVLRNLEEEA GVQDALNIRE 
       550        560        570        580        590    
AISKAKATEN GLVNGENSIP NGTRSENESL NQESKRAVED AKGSSSDSTA GVKE



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Evidence Names:


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Protein Neighborhood

Domains & Features

1 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q86TU7-1-unknown MGKKSR... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q86TU7-1-unknown MGKKSR... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt89350
    Q86TU7-1-unknown MGKKSR... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt89351

C-termini

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)