Q86U44: N6-adenosine-methyltransferase catalytic subunit {ECO:0000305}

General Information

Protein names	- N6-adenosine-methyltransferase catalytic subunit {ECO:0000305} - 2.1.1.348 {ECO:0000269\|PubMed:27281194, ECO:0000269\|PubMed:27373337, ECO:0000269\|PubMed:27627798, ECO:0000269\|PubMed:29348140, ECO:0000269\|PubMed:29506078, ECO:0000269\|PubMed:9409616} - Methyltransferase-like protein 3 {ECO:0000305} - hMETTL3 {ECO:0000303\|PubMed:27373337} - N6-adenosine-methyltransferase 70 kDa subunit - MT-A70
Gene names	METTL3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q86U44

4 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of N6-adenosine-methyltransferase 70 kDa subunit - Isoform 2 of N6-adenosine-methyltransferase catalytic subunit

Sequence View

        10         20         30         40         50         60
MSDTWSSIQA HKKQLDSLRE RLQRRRKQDS GHLDLRNPEA ALSPTFRSDS PVPTAPTSGG
        70         80         90        100        110        120
PKPSTASAVP ELATDPELEK KLLHHLSDLA LTLPTDAVSI CLAISTPDAP ATQDGVESLL
       130        140        150        160        170        180
QKFAAQELIE VKRGLLQDDA HPTLVTYADH SKLSAMMGAV AEKKGPGEVA GTVTGQKRRA
       190        200        210        220        230        240
EQDSTTVAAF ASSLVSGLNS SASEPAKEPA KKSRKHAASD VDLEIESLLN QQSTKEQQSK
       250        260        270        280        290        300
KVSQEILELL NTTTAKEQSI VEKFRSRGRA QVQEFCDYGT KEECMKASDA DRPCRKLHFR
       310        320        330        340        350        360
RIINKHTDES LGDCSFLNTC FHMDTCKYVH YEIDACMDSE APGSKDHTPS QELALTQSVG
       370        380        390        400        410        420
GDSSADRLFP PQWICCDIRY LDVSILGKFA VVMADPPWDI HMELPYGTLT DDEMRRLNIP
       430        440        450        460        470        480
VLQDDGFLFL WVTGRAMELG RECLNLWGYE RVDEIIWVKT NQLQRIIRTG RTGHWLNHGK
       490        500        510        520        530        540
EHCLVGVKGN PQGFNQGLDC DVIVAEVRST SHKPDEIYGM IERLSPGTRK IELFGRPHNV
       550        560        570        580
QPNWITLGNQ LDGIHLLDPD VVARFKQRYP DGIISKPKNL         10         20         30         40         50         60
MSDTWSSIQA HKKQLDSLRE RLQRRRKQDS GHLDLRNPEA ALSPTFRSDS PVPTAPTSGG
        70         80         90        100        110        120
PKPSTASAVP ELATDPELEK KLLHHLSDLA LTLPTDAVSI CLAISTPDAP ATQDGVESLL
       130        140        150        160        170        180
QKFAAQELIE VKRGLLQDDA HPTLVTYADH SKLSAMMGAV AEKKGPGEVA GTVTGQKRRA
       190        200        210        220        230        240
EQDSTTVAAF ASSLVSGLNS SASEPAKEPA KKSRKHAASD VDLEIESLLN QQSTKEQQSK
       250        260        270        280        290        300
KVSQEILELL NTTTAKEQSI VEKFRSRGRA QVQEFCDYGT KEECMKASDA DRPCRKLHFR
       310        320        330        340        350        360
RIINKHTDES LGDCSFLNTC FHMDTCKYVH YEIDACMDSE APGSKDHTPS QELALTQSVG
       370        380        390        400        410        420
GDSSADRLFP PQWICCDIRY LDVSILGKFA VVMADPPWDI HMELPYGTLT DDEMRRLNIP
       430        440        450        460        470        480
VLQDDGFLFL WVTGRAMELG RECLNLWGYE RVDEIIWVKT NQLQRIIRTG RTGHWLNHGK
       490        500        510        520        530        540
EHCLVGVKGN PQGFNQGLDC DVIVAEVRST SHKPDEIYGM IERLSPGTRK IELFGRPHNV
       550        560        570        580
QPNWITLGNQ LDGIHLLDPD VVARFKQRYP DGIISKPKNL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q86U44-2-unknown	MSDTWS...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q86U44-2-Acetylation	SDTWSS...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q86U44-197-	GLNSSA...	197			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q86U44-197-	GLNSSA...	197			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q86U44-285-unknown	MKASDA...	285		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt81688

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...KPKNL	580		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...KPKNL	580	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...KPKNL	580		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)