TopFIND 4.0

Q86UT5: Na(+)/H(+) exchange regulatory cofactor NHE-RF4

General Information

Protein names
- Na(+)/H(+) exchange regulatory cofactor NHE-RF4
- NHERF-4
- Intestinal and kidney-enriched PDZ protein
- Natrium-phosphate cotransporter IIa C-terminal-associated protein 2
- Na/Pi cotransporter C-terminal-associated protein 2
- NaPi-Cap2
- PDZ domain-containing protein 2
- PDZ domain-containing protein 3
- Sodium-hydrogen exchanger regulatory factor 4
Gene names PDZD3
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q86UT5

1

N-termini

2

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MVTPSPPGNH SLSLEAPRLH TASDLLGNHS LGLPLITALV GSRDRRGRVF SPVPVPLPTN 
        70         80         90        100        110        120 
PTTQHPTRQK LPSTLSGHRV CQAHGEPVLG LCPLLPLFCC PPHPPDPWSL ERPRFCLLSK 
       130        140        150        160        170        180 
EEGKSFGFHL QQELGRAGHV VCRVDPGTSA QRQGLQEGDR ILAVNNDVVE HEDYAVVVRR 
       190        200        210        220        230        240 
IRASSPRVLL TVLARHAHDV ARAQLGEDAH LCPTLGPGVR PRLCHIVKDE GGFGFSVTHG 
       250        260        270        280        290        300 
NQGPFWLVLS TGGAAERAGV PPGARLLEVN GVSVEKFTHN QLTRKLWQSG QQVTLLVAGP 
       310        320        330        340        350        360 
EVEEQCRQLG LPLAAPLAEG WALPTKPRCL HLEKGPQGFG FLLREEKGLD GRPGQFLWEV 
       370        380        390        400        410        420 
DPGLPAKKAG MQAGDRLVAV AGESVEGLGH EETVSRIQGQ GSCVSLTVVD PEADRFFSMV 
       430        440        450        460        470        480 
RLSPLLFLEN TEAPASPRGS SSASLVETED PSLEDTSVPS VPLGSRQCFL YPGPGGSYGF 
       490        500        510        520        530        540 
RLSCVASGPR LFISQVTPGG SAARAGLQVG DVILEVNGYP VGGQNDLERL QQLPEAEPPL 
       550        560        570    
CLKLAARSLR GLEAWIPPGA AEDWALASDL L

Isoforms

- Isoform 2 of Na(+)/H(+) exchange regulatory cofactor NHE-RF4 - Isoform 3 of Na(+)/H(+) exchange regulatory cofactor NHE-RF4 - Isoform 4 of Na(+)/H(+) exchange regulatory cofactor NHE-RF4 - Isoform 5 of Na(+)/H(+) exchange regulatory cofactor NHE-RF4

Sequence View

        10         20         30         40         50         60 
MVTPSPPGNH SLSLEAPRLH TASDLLGNHS LGLPLITALV GSRDRRGRVF SPVPVPLPTN 
        70         80         90        100        110        120 
PTTQHPTRQK LPSTLSGHRV CQAHGEPVLG LCPLLPLFCC PPHPPDPWSL ERPRFCLLSK 
       130        140        150        160        170        180 
EEGKSFGFHL QQELGRAGHV VCRVDPGTSA QRQGLQEGDR ILAVNNDVVE HEDYAVVVRR 
       190        200        210        220        230        240 
IRASSPRVLL TVLARHAHDV ARAQLGEDAH LCPTLGPGVR PRLCHIVKDE GGFGFSVTHG 
       250        260        270        280        290        300 
NQGPFWLVLS TGGAAERAGV PPGARLLEVN GVSVEKFTHN QLTRKLWQSG QQVTLLVAGP 
       310        320        330        340        350        360 
EVEEQCRQLG LPLAAPLAEG WALPTKPRCL HLEKGPQGFG FLLREEKGLD GRPGQFLWEV 
       370        380        390        400        410        420 
DPGLPAKKAG MQAGDRLVAV AGESVEGLGH EETVSRIQGQ GSCVSLTVVD PEADRFFSMV 
       430        440        450        460        470        480 
RLSPLLFLEN TEAPASPRGS SSASLVETED PSLEDTSVPS VPLGSRQCFL YPGPGGSYGF 
       490        500        510        520        530        540 
RLSCVASGPR LFISQVTPGG SAARAGLQVG DVILEVNGYP VGGQNDLERL QQLPEAEPPL 
       550        560        570    
CLKLAARSLR GLEAWIPPGA AEDWALASDL L         10         20         30         40         50         60 
MVTPSPPGNH SLSLEAPRLH TASDLLGNHS LGLPLITALV GSRDRRGRVF SPVPVPLPTN 
        70         80         90        100        110        120 
PTTQHPTRQK LPSTLSGHRV CQAHGEPVLG LCPLLPLFCC PPHPPDPWSL ERPRFCLLSK 
       130        140        150        160        170        180 
EEGKSFGFHL QQELGRAGHV VCRVDPGTSA QRQGLQEGDR ILAVNNDVVE HEDYAVVVRR 
       190        200        210        220        230        240 
IRASSPRVLL TVLARHAHDV ARAQLGEDAH LCPTLGPGVR PRLCHIVKDE GGFGFSVTHG 
       250        260        270        280        290        300 
NQGPFWLVLS TGGAAERAGV PPGARLLEVN GVSVEKFTHN QLTRKLWQSG QQVTLLVAGP 
       310        320        330        340        350        360 
EVEEQCRQLG LPLAAPLAEG WALPTKPRCL HLEKGPQGFG FLLREEKGLD GRPGQFLWEV 
       370        380        390        400        410        420 
DPGLPAKKAG MQAGDRLVAV AGESVEGLGH EETVSRIQGQ GSCVSLTVVD PEADRFFSMV 
       430        440        450        460        470        480 
RLSPLLFLEN TEAPASPRGS SSASLVETED PSLEDTSVPS VPLGSRQCFL YPGPGGSYGF 
       490        500        510        520        530        540 
RLSCVASGPR LFISQVTPGG SAARAGLQVG DVILEVNGYP VGGQNDLERL QQLPEAEPPL 
       550        560        570    
CLKLAARSLR GLEAWIPPGA AEDWALASDL L         10         20         30         40         50         60 
MVTPSPPGNH SLSLEAPRLH TASDLLGNHS LGLPLITALV GSRDRRGRVF SPVPVPLPTN 
        70         80         90        100        110        120 
PTTQHPTRQK LPSTLSGHRV CQAHGEPVLG LCPLLPLFCC PPHPPDPWSL ERPRFCLLSK 
       130        140        150        160        170        180 
EEGKSFGFHL QQELGRAGHV VCRVDPGTSA QRQGLQEGDR ILAVNNDVVE HEDYAVVVRR 
       190        200        210        220        230        240 
IRASSPRVLL TVLARHAHDV ARAQLGEDAH LCPTLGPGVR PRLCHIVKDE GGFGFSVTHG 
       250        260        270        280        290        300 
NQGPFWLVLS TGGAAERAGV PPGARLLEVN GVSVEKFTHN QLTRKLWQSG QQVTLLVAGP 
       310        320        330        340        350        360 
EVEEQCRQLG LPLAAPLAEG WALPTKPRCL HLEKGPQGFG FLLREEKGLD GRPGQFLWEV 
       370        380        390        400        410        420 
DPGLPAKKAG MQAGDRLVAV AGESVEGLGH EETVSRIQGQ GSCVSLTVVD PEADRFFSMV 
       430        440        450        460        470        480 
RLSPLLFLEN TEAPASPRGS SSASLVETED PSLEDTSVPS VPLGSRQCFL YPGPGGSYGF 
       490        500        510        520        530        540 
RLSCVASGPR LFISQVTPGG SAARAGLQVG DVILEVNGYP VGGQNDLERL QQLPEAEPPL 
       550        560        570    
CLKLAARSLR GLEAWIPPGA AEDWALASDL L         10         20         30         40         50         60 
MVTPSPPGNH SLSLEAPRLH TASDLLGNHS LGLPLITALV GSRDRRGRVF SPVPVPLPTN 
        70         80         90        100        110        120 
PTTQHPTRQK LPSTLSGHRV CQAHGEPVLG LCPLLPLFCC PPHPPDPWSL ERPRFCLLSK 
       130        140        150        160        170        180 
EEGKSFGFHL QQELGRAGHV VCRVDPGTSA QRQGLQEGDR ILAVNNDVVE HEDYAVVVRR 
       190        200        210        220        230        240 
IRASSPRVLL TVLARHAHDV ARAQLGEDAH LCPTLGPGVR PRLCHIVKDE GGFGFSVTHG 
       250        260        270        280        290        300 
NQGPFWLVLS TGGAAERAGV PPGARLLEVN GVSVEKFTHN QLTRKLWQSG QQVTLLVAGP 
       310        320        330        340        350        360 
EVEEQCRQLG LPLAAPLAEG WALPTKPRCL HLEKGPQGFG FLLREEKGLD GRPGQFLWEV 
       370        380        390        400        410        420 
DPGLPAKKAG MQAGDRLVAV AGESVEGLGH EETVSRIQGQ GSCVSLTVVD PEADRFFSMV 
       430        440        450        460        470        480 
RLSPLLFLEN TEAPASPRGS SSASLVETED PSLEDTSVPS VPLGSRQCFL YPGPGGSYGF 
       490        500        510        520        530        540 
RLSCVASGPR LFISQVTPGG SAARAGLQVG DVILEVNGYP VGGQNDLERL QQLPEAEPPL 
       550        560        570    
CLKLAARSLR GLEAWIPPGA AEDWALASDL L



Filter Information:


(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


Database:


Lab:



Protein Neighborhood

Domains & Features

1 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q86UT5-1-unknown MVTPSP... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q86UT5-1-unknown MVTPSP... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt82835

C-termini

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)