Q86V25: Tubulinyl-Tyr carboxypeptidase 2 {ECO:0000305}

General Information

Protein names	- Tubulinyl-Tyr carboxypeptidase 2 {ECO:0000305} - 3.4.17.17 {ECO:0000269\|PubMed:29146869} - Vasohibin-2 {ECO:0000303\|PubMed:16528006} - Vasohibin-like protein
Gene names	VASH2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q86V25

4 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Vasohibin-2 - Isoform 3 of Vasohibin-2 - Isoform 4 of Vasohibin-2 - Isoform 5 of Vasohibin-2 - Isoform 6 of Vasohibin-2 - Isoform 2 of Tubulinyl-Tyr carboxypeptidase 2 - Isoform 3 of Tubulinyl-Tyr carboxypeptidase 2 - Isoform 4 of Tubulinyl-Tyr carboxypeptidase 2 - Isoform 5 of Tubulinyl-Tyr carboxypeptidase 2 - Isoform 6 of Tubulinyl-Tyr carboxypeptidase 2

Sequence View

        10         20         30         40         50         60
MTGSAADTHR CPHPKGAKGT RSRSSHARPV SLATSGGSEE EDKDGGVLFH VNKSGFPIDS
        70         80         90        100        110        120
HTWERMWMHV AKVHPKGGEM VGAIRNAAFL AKPSIPQVPN YRLSMTIPDW LQAIQNYMKT
       130        140        150        160        170        180
LQYNHTGTQF FEIRKMRPLS GLMETAKEMT RESLPIKCLE AVILGIYLTN GQPSIERFPI
       190        200        210        220        230        240
SFKTYFSGNY FHHVVLGIYC NGRYGSLGMS RRAELMDKPL TFRTLSDLIF DFEDSYKKYL
       250        260        270        280        290        300
HTVKKVKIGL YVPHEPHSFQ PIEWKQLVLN VSKMLRADIR KELEKYARDM RMKILKPASA
       310        320        330        340        350
HSPTQVRSRG KSLSPRRRQA SPPRRLGRRE KSPALPEKKV ADLSTLNEVG YQIRI         10         20         30         40         50         60
MTGSAADTHR CPHPKGAKGT RSRSSHARPV SLATSGGSEE EDKDGGVLFH VNKSGFPIDS
        70         80         90        100        110        120
HTWERMWMHV AKVHPKGGEM VGAIRNAAFL AKPSIPQVPN YRLSMTIPDW LQAIQNYMKT
       130        140        150        160        170        180
LQYNHTGTQF FEIRKMRPLS GLMETAKEMT RESLPIKCLE AVILGIYLTN GQPSIERFPI
       190        200        210        220        230        240
SFKTYFSGNY FHHVVLGIYC NGRYGSLGMS RRAELMDKPL TFRTLSDLIF DFEDSYKKYL
       250        260        270        280        290        300
HTVKKVKIGL YVPHEPHSFQ PIEWKQLVLN VSKMLRADIR KELEKYARDM RMKILKPASA
       310        320        330        340        350
HSPTQVRSRG KSLSPRRRQA SPPRRLGRRE KSPALPEKKV ADLSTLNEVG YQIRI         10         20         30         40         50         60
MTGSAADTHR CPHPKGAKGT RSRSSHARPV SLATSGGSEE EDKDGGVLFH VNKSGFPIDS
        70         80         90        100        110        120
HTWERMWMHV AKVHPKGGEM VGAIRNAAFL AKPSIPQVPN YRLSMTIPDW LQAIQNYMKT
       130        140        150        160        170        180
LQYNHTGTQF FEIRKMRPLS GLMETAKEMT RESLPIKCLE AVILGIYLTN GQPSIERFPI
       190        200        210        220        230        240
SFKTYFSGNY FHHVVLGIYC NGRYGSLGMS RRAELMDKPL TFRTLSDLIF DFEDSYKKYL
       250        260        270        280        290        300
HTVKKVKIGL YVPHEPHSFQ PIEWKQLVLN VSKMLRADIR KELEKYARDM RMKILKPASA
       310        320        330        340        350
HSPTQVRSRG KSLSPRRRQA SPPRRLGRRE KSPALPEKKV ADLSTLNEVG YQIRI         10         20         30         40         50         60
MTGSAADTHR CPHPKGAKGT RSRSSHARPV SLATSGGSEE EDKDGGVLFH VNKSGFPIDS
        70         80         90        100        110        120
HTWERMWMHV AKVHPKGGEM VGAIRNAAFL AKPSIPQVPN YRLSMTIPDW LQAIQNYMKT
       130        140        150        160        170        180
LQYNHTGTQF FEIRKMRPLS GLMETAKEMT RESLPIKCLE AVILGIYLTN GQPSIERFPI
       190        200        210        220        230        240
SFKTYFSGNY FHHVVLGIYC NGRYGSLGMS RRAELMDKPL TFRTLSDLIF DFEDSYKKYL
       250        260        270        280        290        300
HTVKKVKIGL YVPHEPHSFQ PIEWKQLVLN VSKMLRADIR KELEKYARDM RMKILKPASA
       310        320        330        340        350
HSPTQVRSRG KSLSPRRRQA SPPRRLGRRE KSPALPEKKV ADLSTLNEVG YQIRI         10         20         30         40         50         60
MTGSAADTHR CPHPKGAKGT RSRSSHARPV SLATSGGSEE EDKDGGVLFH VNKSGFPIDS
        70         80         90        100        110        120
HTWERMWMHV AKVHPKGGEM VGAIRNAAFL AKPSIPQVPN YRLSMTIPDW LQAIQNYMKT
       130        140        150        160        170        180
LQYNHTGTQF FEIRKMRPLS GLMETAKEMT RESLPIKCLE AVILGIYLTN GQPSIERFPI
       190        200        210        220        230        240
SFKTYFSGNY FHHVVLGIYC NGRYGSLGMS RRAELMDKPL TFRTLSDLIF DFEDSYKKYL
       250        260        270        280        290        300
HTVKKVKIGL YVPHEPHSFQ PIEWKQLVLN VSKMLRADIR KELEKYARDM RMKILKPASA
       310        320        330        340        350
HSPTQVRSRG KSLSPRRRQA SPPRRLGRRE KSPALPEKKV ADLSTLNEVG YQIRI         10         20         30         40         50         60
MTGSAADTHR CPHPKGAKGT RSRSSHARPV SLATSGGSEE EDKDGGVLFH VNKSGFPIDS
        70         80         90        100        110        120
HTWERMWMHV AKVHPKGGEM VGAIRNAAFL AKPSIPQVPN YRLSMTIPDW LQAIQNYMKT
       130        140        150        160        170        180
LQYNHTGTQF FEIRKMRPLS GLMETAKEMT RESLPIKCLE AVILGIYLTN GQPSIERFPI
       190        200        210        220        230        240
SFKTYFSGNY FHHVVLGIYC NGRYGSLGMS RRAELMDKPL TFRTLSDLIF DFEDSYKKYL
       250        260        270        280        290        300
HTVKKVKIGL YVPHEPHSFQ PIEWKQLVLN VSKMLRADIR KELEKYARDM RMKILKPASA
       310        320        330        340        350
HSPTQVRSRG KSLSPRRRQA SPPRRLGRRE KSPALPEKKV ADLSTLNEVG YQIRI         10         20         30         40         50         60
MTGSAADTHR CPHPKGAKGT RSRSSHARPV SLATSGGSEE EDKDGGVLFH VNKSGFPIDS
        70         80         90        100        110        120
HTWERMWMHV AKVHPKGGEM VGAIRNAAFL AKPSIPQVPN YRLSMTIPDW LQAIQNYMKT
       130        140        150        160        170        180
LQYNHTGTQF FEIRKMRPLS GLMETAKEMT RESLPIKCLE AVILGIYLTN GQPSIERFPI
       190        200        210        220        230        240
SFKTYFSGNY FHHVVLGIYC NGRYGSLGMS RRAELMDKPL TFRTLSDLIF DFEDSYKKYL
       250        260        270        280        290        300
HTVKKVKIGL YVPHEPHSFQ PIEWKQLVLN VSKMLRADIR KELEKYARDM RMKILKPASA
       310        320        330        340        350
HSPTQVRSRG KSLSPRRRQA SPPRRLGRRE KSPALPEKKV ADLSTLNEVG YQIRI         10         20         30         40         50         60
MTGSAADTHR CPHPKGAKGT RSRSSHARPV SLATSGGSEE EDKDGGVLFH VNKSGFPIDS
        70         80         90        100        110        120
HTWERMWMHV AKVHPKGGEM VGAIRNAAFL AKPSIPQVPN YRLSMTIPDW LQAIQNYMKT
       130        140        150        160        170        180
LQYNHTGTQF FEIRKMRPLS GLMETAKEMT RESLPIKCLE AVILGIYLTN GQPSIERFPI
       190        200        210        220        230        240
SFKTYFSGNY FHHVVLGIYC NGRYGSLGMS RRAELMDKPL TFRTLSDLIF DFEDSYKKYL
       250        260        270        280        290        300
HTVKKVKIGL YVPHEPHSFQ PIEWKQLVLN VSKMLRADIR KELEKYARDM RMKILKPASA
       310        320        330        340        350
HSPTQVRSRG KSLSPRRRQA SPPRRLGRRE KSPALPEKKV ADLSTLNEVG YQIRI         10         20         30         40         50         60
MTGSAADTHR CPHPKGAKGT RSRSSHARPV SLATSGGSEE EDKDGGVLFH VNKSGFPIDS
        70         80         90        100        110        120
HTWERMWMHV AKVHPKGGEM VGAIRNAAFL AKPSIPQVPN YRLSMTIPDW LQAIQNYMKT
       130        140        150        160        170        180
LQYNHTGTQF FEIRKMRPLS GLMETAKEMT RESLPIKCLE AVILGIYLTN GQPSIERFPI
       190        200        210        220        230        240
SFKTYFSGNY FHHVVLGIYC NGRYGSLGMS RRAELMDKPL TFRTLSDLIF DFEDSYKKYL
       250        260        270        280        290        300
HTVKKVKIGL YVPHEPHSFQ PIEWKQLVLN VSKMLRADIR KELEKYARDM RMKILKPASA
       310        320        330        340        350
HSPTQVRSRG KSLSPRRRQA SPPRRLGRRE KSPALPEKKV ADLSTLNEVG YQIRI         10         20         30         40         50         60
MTGSAADTHR CPHPKGAKGT RSRSSHARPV SLATSGGSEE EDKDGGVLFH VNKSGFPIDS
        70         80         90        100        110        120
HTWERMWMHV AKVHPKGGEM VGAIRNAAFL AKPSIPQVPN YRLSMTIPDW LQAIQNYMKT
       130        140        150        160        170        180
LQYNHTGTQF FEIRKMRPLS GLMETAKEMT RESLPIKCLE AVILGIYLTN GQPSIERFPI
       190        200        210        220        230        240
SFKTYFSGNY FHHVVLGIYC NGRYGSLGMS RRAELMDKPL TFRTLSDLIF DFEDSYKKYL
       250        260        270        280        290        300
HTVKKVKIGL YVPHEPHSFQ PIEWKQLVLN VSKMLRADIR KELEKYARDM RMKILKPASA
       310        320        330        340        350
HSPTQVRSRG KSLSPRRRQA SPPRRLGRRE KSPALPEKKV ADLSTLNEVG YQIRI

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q86V25-1-unknown	MTGSAA...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q86V25-1-unknown	MTGSAA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt94052
Q86V25-1-unknown	MTGSAA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt94053
Q86V25-66-unknown	MWMHVA...	66	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt94050
Q86V25-66-unknown	MWMHVA...	66	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000430319
Q86V25-66-unknown	MWMHVA...	66	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000355935
Q86V25-66-unknown	MWMHVA...	66	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000419918
Q86V25-66-unknown	MWMHVA...	66	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt101501
Q86V25-66-unknown	MWMHVA...	66	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt101502
Q86V25-105-unknown	MTIPDW...	105	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt94054
Q86V25-105-unknown	MTIPDW...	105	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000429040
Q86V25-105-unknown	MTIPDW...	105	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt101709
Q86V25-105-unknown	MTIPDW...	105	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt101708
Q86V25-143-unknown	METAKE...	143	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt94051
Q86V25-143-unknown	METAKE...	143	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000355931
Q86V25-143-unknown	METAKE...	143	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt101558
Q86V25-143-unknown	METAKE...	143	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt101560
Q86V25-143-unknown	METAKE...	143	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt101559

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...NAAFLA	90	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000419918
...NAAFLA	90	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154281
...NAAFLA	90	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154279
...NAAFLA	90	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154280
...YQIRI	355	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...YQIRI	355	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89672
...YQIRI	355	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89668
...YQIRI	355	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89671

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)