Q86VL8: Multidrug and toxin extrusion protein 2

General Information

Protein names	- Multidrug and toxin extrusion protein 2 - MATE-2 - hMATE-2 - Kidney-specific H(+)/organic cation antiporter - Solute carrier family 47 member 2
Gene names	SLC47A2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q86VL8

2 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Multidrug and toxin extrusion protein 2 - Isoform 3 of Multidrug and toxin extrusion protein 2 - Isoform 4 of Multidrug and toxin extrusion protein 2 - Isoform 5 of Multidrug and toxin extrusion protein 2 - Isoform 6 of Multidrug and toxin extrusion protein 2

Sequence View

        10         20         30         40         50         60
MDSLQDTVAL DHGGCCPALS RLVPRGFGTE MWTLFALSGP LFLFQVLTFM IYIVSTVFCG
        70         80         90        100        110        120
HLGKVELASV TLAVAFVNVC GVSVGVGLSS ACDTLMSQSF GSPNKKHVGV ILQRGALVLL
       130        140        150        160        170        180
LCCLPCWALF LNTQHILLLF RQDPDVSRLT QDYVMIFIPG LPVIFLYNLL AKYLQNQGWL
       190        200        210        220        230        240
KGQEEESPFQ TPGLSILHPS HSHLSRASFH LFQKITWPQV LSGVVGNCVN GVANYALVSV
       250        260        270        280        290        300
LNLGVRGSAY ANIISQFAQT VFLLLYIVLK KLHLETWAGW SSQCLQDWGP FFSLAVPSML
       310        320        330        340        350        360
MICVEWWAYE IGSFLMGLLS VVDLSAQAVI YEVATVTYMI PLGLSIGVCV RVGMALGAAD
       370        380        390        400        410        420
TVQAKRSAVS GVLSIVGISL VLGTLISILK NQLGHIFTND EDVIALVSQV LPVYSVFHVF
       430        440        450        460        470        480
EAICCVYGGV LRGTGKQAFG AAVNAITYYI IGLPLGILLT FVVRMRIMGL WLGMLACVFL
       490        500        510        520        530        540
ATAAFVAYTA RLDWKLAAEE AKKHSGRQQQ QRAESTATRP GPEKAVLSSV ATGSSPGITL
       550        560        570        580        590        600
TTYSRSECHV DFFRTPEEAH ALSAPTSRLS VKQLVIRRGA ALGAASATLM VGLTVRILAT

RH         10         20         30         40         50         60
MDSLQDTVAL DHGGCCPALS RLVPRGFGTE MWTLFALSGP LFLFQVLTFM IYIVSTVFCG
        70         80         90        100        110        120
HLGKVELASV TLAVAFVNVC GVSVGVGLSS ACDTLMSQSF GSPNKKHVGV ILQRGALVLL
       130        140        150        160        170        180
LCCLPCWALF LNTQHILLLF RQDPDVSRLT QDYVMIFIPG LPVIFLYNLL AKYLQNQGWL
       190        200        210        220        230        240
KGQEEESPFQ TPGLSILHPS HSHLSRASFH LFQKITWPQV LSGVVGNCVN GVANYALVSV
       250        260        270        280        290        300
LNLGVRGSAY ANIISQFAQT VFLLLYIVLK KLHLETWAGW SSQCLQDWGP FFSLAVPSML
       310        320        330        340        350        360
MICVEWWAYE IGSFLMGLLS VVDLSAQAVI YEVATVTYMI PLGLSIGVCV RVGMALGAAD
       370        380        390        400        410        420
TVQAKRSAVS GVLSIVGISL VLGTLISILK NQLGHIFTND EDVIALVSQV LPVYSVFHVF
       430        440        450        460        470        480
EAICCVYGGV LRGTGKQAFG AAVNAITYYI IGLPLGILLT FVVRMRIMGL WLGMLACVFL
       490        500        510        520        530        540
ATAAFVAYTA RLDWKLAAEE AKKHSGRQQQ QRAESTATRP GPEKAVLSSV ATGSSPGITL
       550        560        570        580        590        600
TTYSRSECHV DFFRTPEEAH ALSAPTSRLS VKQLVIRRGA ALGAASATLM VGLTVRILAT

RH         10         20         30         40         50         60
MDSLQDTVAL DHGGCCPALS RLVPRGFGTE MWTLFALSGP LFLFQVLTFM IYIVSTVFCG
        70         80         90        100        110        120
HLGKVELASV TLAVAFVNVC GVSVGVGLSS ACDTLMSQSF GSPNKKHVGV ILQRGALVLL
       130        140        150        160        170        180
LCCLPCWALF LNTQHILLLF RQDPDVSRLT QDYVMIFIPG LPVIFLYNLL AKYLQNQGWL
       190        200        210        220        230        240
KGQEEESPFQ TPGLSILHPS HSHLSRASFH LFQKITWPQV LSGVVGNCVN GVANYALVSV
       250        260        270        280        290        300
LNLGVRGSAY ANIISQFAQT VFLLLYIVLK KLHLETWAGW SSQCLQDWGP FFSLAVPSML
       310        320        330        340        350        360
MICVEWWAYE IGSFLMGLLS VVDLSAQAVI YEVATVTYMI PLGLSIGVCV RVGMALGAAD
       370        380        390        400        410        420
TVQAKRSAVS GVLSIVGISL VLGTLISILK NQLGHIFTND EDVIALVSQV LPVYSVFHVF
       430        440        450        460        470        480
EAICCVYGGV LRGTGKQAFG AAVNAITYYI IGLPLGILLT FVVRMRIMGL WLGMLACVFL
       490        500        510        520        530        540
ATAAFVAYTA RLDWKLAAEE AKKHSGRQQQ QRAESTATRP GPEKAVLSSV ATGSSPGITL
       550        560        570        580        590        600
TTYSRSECHV DFFRTPEEAH ALSAPTSRLS VKQLVIRRGA ALGAASATLM VGLTVRILAT

RH         10         20         30         40         50         60
MDSLQDTVAL DHGGCCPALS RLVPRGFGTE MWTLFALSGP LFLFQVLTFM IYIVSTVFCG
        70         80         90        100        110        120
HLGKVELASV TLAVAFVNVC GVSVGVGLSS ACDTLMSQSF GSPNKKHVGV ILQRGALVLL
       130        140        150        160        170        180
LCCLPCWALF LNTQHILLLF RQDPDVSRLT QDYVMIFIPG LPVIFLYNLL AKYLQNQGWL
       190        200        210        220        230        240
KGQEEESPFQ TPGLSILHPS HSHLSRASFH LFQKITWPQV LSGVVGNCVN GVANYALVSV
       250        260        270        280        290        300
LNLGVRGSAY ANIISQFAQT VFLLLYIVLK KLHLETWAGW SSQCLQDWGP FFSLAVPSML
       310        320        330        340        350        360
MICVEWWAYE IGSFLMGLLS VVDLSAQAVI YEVATVTYMI PLGLSIGVCV RVGMALGAAD
       370        380        390        400        410        420
TVQAKRSAVS GVLSIVGISL VLGTLISILK NQLGHIFTND EDVIALVSQV LPVYSVFHVF
       430        440        450        460        470        480
EAICCVYGGV LRGTGKQAFG AAVNAITYYI IGLPLGILLT FVVRMRIMGL WLGMLACVFL
       490        500        510        520        530        540
ATAAFVAYTA RLDWKLAAEE AKKHSGRQQQ QRAESTATRP GPEKAVLSSV ATGSSPGITL
       550        560        570        580        590        600
TTYSRSECHV DFFRTPEEAH ALSAPTSRLS VKQLVIRRGA ALGAASATLM VGLTVRILAT

RH         10         20         30         40         50         60
MDSLQDTVAL DHGGCCPALS RLVPRGFGTE MWTLFALSGP LFLFQVLTFM IYIVSTVFCG
        70         80         90        100        110        120
HLGKVELASV TLAVAFVNVC GVSVGVGLSS ACDTLMSQSF GSPNKKHVGV ILQRGALVLL
       130        140        150        160        170        180
LCCLPCWALF LNTQHILLLF RQDPDVSRLT QDYVMIFIPG LPVIFLYNLL AKYLQNQGWL
       190        200        210        220        230        240
KGQEEESPFQ TPGLSILHPS HSHLSRASFH LFQKITWPQV LSGVVGNCVN GVANYALVSV
       250        260        270        280        290        300
LNLGVRGSAY ANIISQFAQT VFLLLYIVLK KLHLETWAGW SSQCLQDWGP FFSLAVPSML
       310        320        330        340        350        360
MICVEWWAYE IGSFLMGLLS VVDLSAQAVI YEVATVTYMI PLGLSIGVCV RVGMALGAAD
       370        380        390        400        410        420
TVQAKRSAVS GVLSIVGISL VLGTLISILK NQLGHIFTND EDVIALVSQV LPVYSVFHVF
       430        440        450        460        470        480
EAICCVYGGV LRGTGKQAFG AAVNAITYYI IGLPLGILLT FVVRMRIMGL WLGMLACVFL
       490        500        510        520        530        540
ATAAFVAYTA RLDWKLAAEE AKKHSGRQQQ QRAESTATRP GPEKAVLSSV ATGSSPGITL
       550        560        570        580        590        600
TTYSRSECHV DFFRTPEEAH ALSAPTSRLS VKQLVIRRGA ALGAASATLM VGLTVRILAT

RH

Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q86VL8-1-unknown	MDSLQD...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q86VL8-1-unknown	MDSLQD...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt88753
Q86VL8-1-unknown	MDSLQD...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt88754
Q86VL8-1-unknown	MDSLQD...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt88755
Q86VL8-1-unknown	MDSLQD...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt88756
Q86VL8-50-unknown	MIYIVS...	50	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt88752
Q86VL8-50-unknown	MIYIVS...	50	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt105728
Q86VL8-50-unknown	MIYIVS...	50	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt105729
Q86VL8-50-unknown	MIYIVS...	50	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt105730
Q86VL8-50-unknown	MIYIVS...	50	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt105731

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LATRH	602	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LATRH	602	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt84371
...LATRH	602	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt84372

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

TopFIND

Q86VL8: Multidrug and toxin extrusion protein 2

General Information

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Protease Assignment Confidence:

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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates