TopFIND 4.0

Q86VW2: Rho guanine nucleotide exchange factor 25

General Information

Protein names
- Rho guanine nucleotide exchange factor 25
- Guanine nucleotide exchange factor GEFT
- Rac/Cdc42/Rho exchange factor GEFT
- RhoA/Rac/Cdc42 guanine nucleotide exchange factor GEFT
- p63RhoGEF
Gene names ARHGEF25
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q86VW2

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MRGGHKGGRC ACPRVIRKVL AKCGCCFARG GRESYSIAGS EGSISASAAS GLAAPSGPSS 
        70         80         90        100        110        120 
GLSSGPCSPG PPGPVSGLRR WLDHSKHCLS VETEADSGQA GPYENWMLEP ALATGEELPE 
       130        140        150        160        170        180 
LTLLTTLLEG PGDKTQPPEE ETLSQAPESE EEQKKKALER SMYVLSELVE TEKMYVDDLG 
       190        200        210        220        230        240 
QIVEGYMATM AAQGVPESLR GRDRIVFGNI QQIYEWHRDY FLQELQRCLK DPDWLAQLFI 
       250        260        270        280        290        300 
KHERRLHMYV VYCQNKPKSE HVVSEFGDSY FEELRQQLGH RLQLNDLLIK PVQRIMKYQL 
       310        320        330        340        350        360 
LLKDFLKYYN RAGMDTADLE QAVEVMCFVP KRCNDMMTLG RLRGFEGKLT AQGKLLGQDT 
       370        380        390        400        410        420 
FWVTEPEAGG LLSSRGRERR VFLFEQIIIF SEALGGGVRG GTQPGYVYKN SIKVSCLGLE 
       430        440        450        460        470        480 
GNLQGDPCRF ALTSRGPEGG IQRYVLQAAD PAISQAWIKH VAQILESQRD FLNALQSPIE 
       490        500        510        520        530        540 
YQRRESQTNS LGRPRGPGVG SPGRIQLGDQ AQGSTHTPIN GSLPSLLLSP KGEVARALLP 
       550        560        570        580    
LDKQALGDIP QAPHDSPPVS PTPKTPPCQA RLAKLDEDEL 

Isoforms

- Isoform 2 of Rho guanine nucleotide exchange factor 25 - Isoform 3 of Rho guanine nucleotide exchange factor 25

Sequence View

        10         20         30         40         50         60 
MRGGHKGGRC ACPRVIRKVL AKCGCCFARG GRESYSIAGS EGSISASAAS GLAAPSGPSS 
        70         80         90        100        110        120 
GLSSGPCSPG PPGPVSGLRR WLDHSKHCLS VETEADSGQA GPYENWMLEP ALATGEELPE 
       130        140        150        160        170        180 
LTLLTTLLEG PGDKTQPPEE ETLSQAPESE EEQKKKALER SMYVLSELVE TEKMYVDDLG 
       190        200        210        220        230        240 
QIVEGYMATM AAQGVPESLR GRDRIVFGNI QQIYEWHRDY FLQELQRCLK DPDWLAQLFI 
       250        260        270        280        290        300 
KHERRLHMYV VYCQNKPKSE HVVSEFGDSY FEELRQQLGH RLQLNDLLIK PVQRIMKYQL 
       310        320        330        340        350        360 
LLKDFLKYYN RAGMDTADLE QAVEVMCFVP KRCNDMMTLG RLRGFEGKLT AQGKLLGQDT 
       370        380        390        400        410        420 
FWVTEPEAGG LLSSRGRERR VFLFEQIIIF SEALGGGVRG GTQPGYVYKN SIKVSCLGLE 
       430        440        450        460        470        480 
GNLQGDPCRF ALTSRGPEGG IQRYVLQAAD PAISQAWIKH VAQILESQRD FLNALQSPIE 
       490        500        510        520        530        540 
YQRRESQTNS LGRPRGPGVG SPGRIQLGDQ AQGSTHTPIN GSLPSLLLSP KGEVARALLP 
       550        560        570        580    
LDKQALGDIP QAPHDSPPVS PTPKTPPCQA RLAKLDEDEL          10         20         30         40         50         60 
MRGGHKGGRC ACPRVIRKVL AKCGCCFARG GRESYSIAGS EGSISASAAS GLAAPSGPSS 
        70         80         90        100        110        120 
GLSSGPCSPG PPGPVSGLRR WLDHSKHCLS VETEADSGQA GPYENWMLEP ALATGEELPE 
       130        140        150        160        170        180 
LTLLTTLLEG PGDKTQPPEE ETLSQAPESE EEQKKKALER SMYVLSELVE TEKMYVDDLG 
       190        200        210        220        230        240 
QIVEGYMATM AAQGVPESLR GRDRIVFGNI QQIYEWHRDY FLQELQRCLK DPDWLAQLFI 
       250        260        270        280        290        300 
KHERRLHMYV VYCQNKPKSE HVVSEFGDSY FEELRQQLGH RLQLNDLLIK PVQRIMKYQL 
       310        320        330        340        350        360 
LLKDFLKYYN RAGMDTADLE QAVEVMCFVP KRCNDMMTLG RLRGFEGKLT AQGKLLGQDT 
       370        380        390        400        410        420 
FWVTEPEAGG LLSSRGRERR VFLFEQIIIF SEALGGGVRG GTQPGYVYKN SIKVSCLGLE 
       430        440        450        460        470        480 
GNLQGDPCRF ALTSRGPEGG IQRYVLQAAD PAISQAWIKH VAQILESQRD FLNALQSPIE 
       490        500        510        520        530        540 
YQRRESQTNS LGRPRGPGVG SPGRIQLGDQ AQGSTHTPIN GSLPSLLLSP KGEVARALLP 
       550        560        570        580    
LDKQALGDIP QAPHDSPPVS PTPKTPPCQA RLAKLDEDEL 



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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q86VW2-1-unknown MRGGHK... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q86VW2-107-unknown MLEPAL... 107 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt67428
    Q86VW2-107-unknown MLEPAL... 107 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt101570

C-termini

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)