TopFIND 4.0

Q86XT4: E3 ubiquitin-protein ligase TRIM50

General Information

Protein names
- E3 ubiquitin-protein ligase TRIM50
- 2.3.2.27 {ECO:0000269|PubMed:29604308}
- RING-type E3 ubiquitin transferase TRIM50 {ECO:0000305}
- Tripartite motif-containing protein 50
Gene names TRIM50
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q86XT4

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MAWQVSLLEL EDWLQCPICL EVFKEPLMLQ CGHSYCKGCL VSLSCHLDAE LRCPVCRQAV 
        70         80         90        100        110        120 
DGSSSLPNVS LARVIEALRL PGDPEPKVCV HHRNPLSLFC EKDQELICGL CGLLGSHQHH 
       130        140        150        160        170        180 
PVTPVSTVYS RMKEELAALI SELKQEQKKV DELIAKLVNN RTRIVNESDV FSWVIRREFQ 
       190        200        210        220        230        240 
ELHHLVDEEK ARCLEGIGGH TRGLVASLDM QLEQAQGTRE RLAQAECVLE QFGNEDHHKF 
       250        260        270        280        290        300 
IRKFHSMASR AEMPQARPLE GAFSPISFKP GLHQADIKLT VWKRLFRKVL PAPEPLKLDP 
       310        320        330        340        350        360 
ATAHPLLELS KGNTVVQCGL LAQRRASQPE RFDYSTCVLA SRGFSCGRHY WEVVVGSKSD 
       370        380        390        400        410        420 
WRLGVIKGTA SRKGKLNRSP EHGVWLIGLK EGRVYEAFAC PRVPLPVAGH PHRIGLYLHY 
       430        440        450        460        470        480 
EQGELTFFDA DRPDDLRPLY TFQADFQGKL YPILDTCWHE RGSNSLPMVL PPPSGPGPLS 
   
PEQPTKL

Isoforms

- Isoform Beta of E3 ubiquitin-protein ligase TRIM50

Sequence View

        10         20         30         40         50         60 
MAWQVSLLEL EDWLQCPICL EVFKEPLMLQ CGHSYCKGCL VSLSCHLDAE LRCPVCRQAV 
        70         80         90        100        110        120 
DGSSSLPNVS LARVIEALRL PGDPEPKVCV HHRNPLSLFC EKDQELICGL CGLLGSHQHH 
       130        140        150        160        170        180 
PVTPVSTVYS RMKEELAALI SELKQEQKKV DELIAKLVNN RTRIVNESDV FSWVIRREFQ 
       190        200        210        220        230        240 
ELHHLVDEEK ARCLEGIGGH TRGLVASLDM QLEQAQGTRE RLAQAECVLE QFGNEDHHKF 
       250        260        270        280        290        300 
IRKFHSMASR AEMPQARPLE GAFSPISFKP GLHQADIKLT VWKRLFRKVL PAPEPLKLDP 
       310        320        330        340        350        360 
ATAHPLLELS KGNTVVQCGL LAQRRASQPE RFDYSTCVLA SRGFSCGRHY WEVVVGSKSD 
       370        380        390        400        410        420 
WRLGVIKGTA SRKGKLNRSP EHGVWLIGLK EGRVYEAFAC PRVPLPVAGH PHRIGLYLHY 
       430        440        450        460        470        480 
EQGELTFFDA DRPDDLRPLY TFQADFQGKL YPILDTCWHE RGSNSLPMVL PPPSGPGPLS 
   
PEQPTKL



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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q86XT4-1-unknown MAWQVS... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q86XT4-1-unknown MAWQVS... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt93038

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...QPTKL 487 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...QPTKL 487 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt88656

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)